Open Access

Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma

  • Authors:
    • Jing Peng
    • Hai‑Cheng Wang
    • Yang Liu
    • Jiu‑Hui Jiang
    • Wan‑Qi Lv
    • Yue Yang
    • Cui‑Ying Li
    • Xiao‑Yan Qiu
  • View Affiliations

  • Published online on: August 21, 2017     https://doi.org/10.3892/ol.2017.6782
  • Pages: 4491-4498
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer cell‑derived immunoglobulin G (cancer‑IgG) has been implicated in the pathogenesis and progression of various types of cancer. However, its role in salivary adenoid cystic carcinoma (SACC) remains unclear. The present study aimed to investigate the effects of cancer‑IgG on metastasis and prognosis in 96 patients with SACC. Immunohistochemical staining showed that cancer‑IgG expression was present in all 96 individual SACC tissues. Additionally, high cancer‑IgG expression was significantly correlated with metastasis, nerve invasion and recurrence in SACC (P<0.05). Moreover, cancer‑IgG expression was significantly correlated with the survival duration of patients with SACC (P<0.05). Proliferation, cell motility and invasion all decreased significantly following knockdown of cancer‑IgG in SACC cells (P<0.05) through population‑doubling time, wound healing and transwell invasion assays. Additionally, cancer‑IgG‑knockdown in SACC cells induced the increased expression of E‑cadherin and matrix metalloproteinase 9, and promoted the epithelial‑mesenchymal transition, but decreased the expression of F‑actin filaments. Taken together, these results showed that the high expression of cancer‑IgG was strongly associated with metastasis, recurrence and invasion in SACC, suggesting that cancer‑IgG expression could serve as a useful biomarker to predict the prognosis of the disease.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Peng J, Wang HC, Liu Y, Jiang JH, Lv WQ, Yang Y, Li CY and Qiu XY: Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma. Oncol Lett 14: 4491-4498, 2017
APA
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y. ... Qiu, X. (2017). Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma. Oncology Letters, 14, 4491-4498. https://doi.org/10.3892/ol.2017.6782
MLA
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y., Li, C., Qiu, X."Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma". Oncology Letters 14.4 (2017): 4491-4498.
Chicago
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y., Li, C., Qiu, X."Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma". Oncology Letters 14, no. 4 (2017): 4491-4498. https://doi.org/10.3892/ol.2017.6782