Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer

Yang,Changcheng; Cao,Manlin; Liu,Yiwen; He,Yiqing; Yang,Cuixia; Du,Yan; Wang,Wenjuan; Zhang,Guoliang; Wu,Man; Zhou,Muqing; Gao,Feng

doi:10.3892/ol.2017.6791

Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer

Authors:
- Changcheng Yang
- Manlin Cao
- Yiwen Liu
- Yiqing He
- Cuixia Yang
- Yan Du
- Wenjuan Wang
- Guoliang Zhang
- Man Wu
- Muqing Zhou
- Feng Gao
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Affiliations: Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, Department of Rehabilitation Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, Department of Molecular Biology and Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
Published online on: August 23, 2017 https://doi.org/10.3892/ol.2017.6791
Pages: 4758-4766
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Carcinoembryonic antigen‑related cell adhesion molecule 1 (CEACAM1), a cell‑cell adhesion molecule, has been revealed to perform an important role in tumor progression. Although there are a number of studies on CEACAM1 in patients with breast cancer, there is limited information on the roles of CEACAM1 in breast cancer metastasis. The present study aimed to identify whether CEACAM1 is involved in breast cancer development and to investigate the underlying mechanisms. First, the expression of CEACAM1 was observed in patients with breast cancer, and the association between CEACAM1 expression levels and migration and invasion of breast cancer cells was analyzed. As there are 12 isoforms of CEACAM1, of which CEACAM1‑4S dominates in the human breast epithelium, subsequent study focused on CEACAM1‑4S as a representative of all the isoforms. Results of the present study demonstrated that CEACAM1‑4S suppresses breast cancer cell invasion and migration in a manner that is dependent on the balance between matrix metalloproteinase 2/tissue inhibitor of metalloproteinase 2 and E‑/N‑cadherin expression. In addition, CEACAM1‑4S was likely to cause reversal of epithelial‑mesenchymal transition of breast cancer cells through repressing Smad2 and signal transducer and phosphorylation of activator of transcription 3. In conclusion, the present study demonstrated that CEACAM1‑4S performs an inhibitory role in breast cancer metastasis, and restoring CEACAM1‑4S expression may provide a novel strategy for therapy of patients with metastatic breast cancer.

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