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Article

The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells

  • Authors:
    • Patricia Adamo
    • Sean Porazinski
    • Shavanthi Rajatileka
    • Samantha Jumbe
    • Rachel Hagen
    • Man‑Kim Cheung
    • Ian Wilson
    • Michael R. Ladomery
  • View Affiliations / Copyright

    Affiliations: Faculty of Health and Applied Sciences, University of the West of England, Bristol BS16 1QY, UK
  • Pages: 5605-5610
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/ol.2017.6841
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Abstract

The oncogene ETS‑related gene (ERG) encodes a transcription factor with roles in the regulation of haematopoiesis, angiogenesis, vasculogenesis, inflammation, migration and invasion. The ERG oncogene is activated in >50% of prostate cancer cases, generally through a gene fusion with the androgen‑responsive promoter of transmembrane protease serine 2. Phosphatase and tensin homologue (PTEN) is an important tumour suppressor gene that is often inactivated in cancer. ERG overexpression combined with PTEN inactivation or loss is often associated with aggressive prostate cancer. The present study aimed to determine whether or not ERG regulates PTEN transcription directly. ERG was demonstrated to bind to the PTEN promoter and repress its transcription. ERG overexpression reduced endogenous PTEN expression, whereas ERG knockdown increased PTEN expression. The ability of ERG to repress PTEN may contribute to a more cancer‑permissive environment.
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Copy and paste a formatted citation
Spandidos Publications style
Adamo P, Porazinski S, Rajatileka S, Jumbe S, Hagen R, Cheung MK, Wilson I and Ladomery MR: The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncol Lett 14: 5605-5610, 2017.
APA
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M. ... Ladomery, M.R. (2017). The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncology Letters, 14, 5605-5610. https://doi.org/10.3892/ol.2017.6841
MLA
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M., Wilson, I., Ladomery, M. R."The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells". Oncology Letters 14.5 (2017): 5605-5610.
Chicago
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M., Wilson, I., Ladomery, M. R."The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells". Oncology Letters 14, no. 5 (2017): 5605-5610. https://doi.org/10.3892/ol.2017.6841
Copy and paste a formatted citation
x
Spandidos Publications style
Adamo P, Porazinski S, Rajatileka S, Jumbe S, Hagen R, Cheung MK, Wilson I and Ladomery MR: The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncol Lett 14: 5605-5610, 2017.
APA
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M. ... Ladomery, M.R. (2017). The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells. Oncology Letters, 14, 5605-5610. https://doi.org/10.3892/ol.2017.6841
MLA
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M., Wilson, I., Ladomery, M. R."The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells". Oncology Letters 14.5 (2017): 5605-5610.
Chicago
Adamo, P., Porazinski, S., Rajatileka, S., Jumbe, S., Hagen, R., Cheung, M., Wilson, I., Ladomery, M. R."The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells". Oncology Letters 14, no. 5 (2017): 5605-5610. https://doi.org/10.3892/ol.2017.6841
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