Research progress on circadian clock genes in common abdominal malignant tumors (Review)
- Authors:
- Sheng‑Li Yang
- Quan‑Guang Ren
- Lu Wen
- Jian‑Li Hu
- Heng‑Yi Wang
-
Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China, Department of Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China - Published online on: August 31, 2017 https://doi.org/10.3892/ol.2017.6856
- Pages: 5091-5098
-
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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 |
|
Montenegro-Montero A, Canessa P and Larrondo LF: Around the fungal clock: Recent advances in the molecular study of circadian clocks in neurospora and other fungi. Adv Genet. 92:107–184. 2015.PubMed/NCBI | |
|
Endo M: Tissue-specific circadian clocks in plants. Curr Opin Plant Biol. 29:44–49. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Di Cara F and King-Jones K: How clocks and hormones act in concert to control the timing of insect development. Curr Top Dev Biol. 105:1–36. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Tomioka K: Chronobiology of crickets: A review. Zoolog Sci. 31:624–632. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Numata H, Miyazaki Y and Ikeno T: Common features in diverse insect clocks. Zoological Lett. 1:102015. View Article : Google Scholar : PubMed/NCBI | |
|
Uryu O, Ameku T and Niwa R: Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster. Zoological Lett. 1:322015. View Article : Google Scholar : PubMed/NCBI | |
|
Heller HC and Ruby NF: Sleep and circadian rhythms in mammalian torpor. Annu Rev Physiol. 66:275–289. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ruby NF: Hibernation: When good clocks go cold. J Biol Rhythms. 18:275–286. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Coomans CP, Ramkisoensing A and Meijer JH: The suprachiasmatic nuclei as a seasonal clock. Front Neuroendocrinol. 37:29–42. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Leslie M: Circadian rhythms. Sleep study suggests triggers for diabetes and obesity. Science. 336:1432012. View Article : Google Scholar : PubMed/NCBI | |
|
Bass J: Circadian topology of metabolism. Nature. 491:348–356. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Richards J, Diaz AN and Gumz ML: Clock genes in hypertension: Novel insights from rodent models. Blood Press Monit. 19:249–254. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
McLoughlin SC, Haines P and FitzGerald GA: Clocks and cardiovascular function. Methods Enzymol. 552:211–228. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Robinson I and Reddy AB: Molecular mechanisms of the circadian clockwork in mammals. FEBS Lett. 588:2477–2483. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Li S and Zhang L: Circadian control of global transcription. Biomed Res Int. 2015:1878092015. View Article : Google Scholar : PubMed/NCBI | |
|
Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, Green CB, Zhang H and Takahashi JS: Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 337:189–194. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, et al: Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature. 485:123–127. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Bersten DC, Sullivan AE, Peet DJ and Whitelaw ML: bHLH-PAS proteins in cancer. Nat Rev Cancer. 13:827–841. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Mazzoccoli G, Pazienza V and Vinciguerra M: Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiol Int. 29:227–251. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, et al: Positional cloning of the mouse circadian clock gene. Cell. 89:641–653. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Steeves TD, King DP, Zhao Y, Sangoram AM, Du F, Bowcock AM, Moore RY and Takahashi JS: Molecular cloning and characterization of the human CLOCK gene: Expression in the suprachiasmatic nuclei. Genomics. 57:189–200. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH and Turek FW: The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci. 20:8138–8143. 2000.PubMed/NCBI | |
|
Lee J, Lee S, Chung S, Park N, Son GH, An H, Jang J, Chang DJ, Suh YG and Kim K: Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism. Biochem Biophys Res Commun. 469:580–586. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ikeda M and Nomura M: cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun. 233:258–264. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS and Bradfield CA: Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 103:1009–1017. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, et al: Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart. J Biol Rhythms. 29:257–276. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kennaway DJ, Varcoe TJ, Voultsios A and Boden MJ: Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. PLoS One. 8:e652552013. View Article : Google Scholar : PubMed/NCBI | |
|
Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB and Fitzgerald GA: BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2:e3772004. View Article : Google Scholar : PubMed/NCBI | |
|
Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP and Kondratov RV: BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). 6:48–57. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ali AA, Schwarz-Herzke B, Stahr A, Prozorovski T, Aktas O and von Gall C: Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice. Aging (Albany NY). 7:435–449. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Konopka RJ and Benzer S: Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci USA. 68:2112–2116. 1971. View Article : Google Scholar : PubMed/NCBI | |
|
Lengyel Z, Lovig C, Kommedal S, Keszthelyi R, Szekeres G, Battyáni Z, Csernus V and Nagy AD: Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors. Tumour Biol. 34:811–819. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao N, Yang K, Yang G, Chen D, Tang H, Zhao D and Zhao C: Aberrant expression of clock gene period1 and its correlations with the growth, proliferation and metastasis of buccal squamous cell carcinoma. PLoS One. 8:e558942013. View Article : Google Scholar : PubMed/NCBI | |
|
Hsu CM, Lin PM, Lai CC, Lin HC, Lin SF and Yang MY: PER1 and CLOCK: Potential circulating biomarkers for head and neck squamous cell carcinoma. Head Neck. 36:1018–1026. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H and Hengstler JG: Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle. 13:3282–3291. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu B, Xu K, Jiang Y and Li X: Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. Int J Clin Exp Pathol. 7:7863–7871. 2014.PubMed/NCBI | |
|
Larkin JC and Woolford JL Jr: Molecular cloning and analysis of the CRY1 gene: A yeast ribosomal protein gene. Nucleic Acids Res. 11:403–420. 1983. View Article : Google Scholar : PubMed/NCBI | |
|
Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH and Reppert SM: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 98:193–205. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW and McKnight SL: Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci USA. 94:713–718. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D and FitzGerald GA: Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock. Cell. 105:877–889. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan P, Wang S, Zhou F, Wan S, Yang Y, Huang X, Zhang Z, Zhu Y, Zhang H and Xing J: Functional polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients. Cancer Sci. 105:825–832. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Xue X, Liu F, Han Y, Li P, Yuan B, Wang X, Chen Y, Kuang Y, Zhi Q and Zhao H: Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer. Biochem Biophys Res Commun. 450:1058–1062. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rana S, Shahid A, Ullah H and Mahmood S: Lack of association of the NPAS2 gene Ala394Thr polymorphism (rs2305160:G>A) with risk of chronic lymphocytic leukemia. Asian Pac J Cancer Prev. 15:7169–7174. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Fish KJ, Cegielska A, Getman ME, Landes GM and Virshup DM: Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. J Biol Chem. 270:14875–14883. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Camacho F, Cilio M, Guo Y, Virshup DM, Patel K, Khorkova O, Styren S, Morse B, Yao Z and Keesler GA: Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. FEBS Lett. 489:159–165. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Tsuchiya Y, Akashi M, Matsuda M, Goto K, Miyata Y, Node K and Nishida E: Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms. Sci Signal. 2:ra262009. View Article : Google Scholar : PubMed/NCBI | |
|
Lee H, Chen R, Lee Y, Yoo S and Lee C: Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci USA. 106:21359–21364. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Bonnelye E, Vanacker JM, Desbiens X, Begue A, Stehelin D and Laudet V: Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development. Cell Growth Differ. 5:1357–1365. 1994.PubMed/NCBI | |
|
Lazar MA, Hodin RA, Darling DS and Chin WW: A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol. 9:1128–1136. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Crumbley C and Burris TP: Direct regulation of CLOCK expression by REV-ERB. PLoS One. 6:e172902011. View Article : Google Scholar : PubMed/NCBI | |
|
Dardente H, Fustin JM and Hazlerigg DG: Transcriptional feedback loops in the ovine circadian clock. Comp Biochem Physiol A Mol Integr Physiol. 153:391–398. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Crumbley C, Wang Y, Kojetin DJ and Burris TP: Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene. J Biol Chem. 285:35386–35392. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Takeda Y, Kang HS, Angers M and Jetten AM: Retinoic acid-related orphan receptor gamma directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Res. 39:4769–4782. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J and Lazar MA: Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev. 26:657–667. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mazzoccoli G, Cai Y, Liu S, Francavilla M, Giuliani F, Piepoli A, Pazienza V, Vinciguerra M, Yamamoto T and Takumi T: REV-ERBα and the clock gene machinery in mouse peripheral tissues: A possible role as a synchronizing hinge. J Biol Regul Homeost Agents. 26:265–276. 2012.PubMed/NCBI | |
|
Bhargava A, Herzel H and Ananthasubramaniam B: Mining for novel candidate clock genes in the circadian regulatory network. BMC Syst Biol. 9:782015. View Article : Google Scholar : PubMed/NCBI | |
|
Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M and Kato Y: Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem Biophys Res Commun. 236:294–298. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, Yoshida E, Suardita K, Matsuda Y and Kato Y: Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun. 280:164–171. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Noshiro M, Furukawa M, Honma S, Kawamoto T, Hamada T, Honma K and Kato Y: Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice. J Biol Rhythms. 20:404–418. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Wu T, Ni Y, Zhuge F, Sun L, Xu B, Kato H and Fu Z: Significant dissociation of expression patterns of the basic helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney. J Exp Biol. 214:1257–1263. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y and Honma K: Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 419:841–844. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y and Yan B: DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 278:16899–16907. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, Takai Y and Kijima H: Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. Biomed Res. 36:89–96. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jinhua H, Zhao M, Wei S, Haitao Y, Yuwen W, Lili W, Wei L and Jian Y: Down regulation of differentiated embryo-chondrocyte expressed gene 1 is related to the decrease of osteogenic capacity. Curr Drug Targets. 15:432–441. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
You J, Lin L, Liu Q, Zhu T, Xia K and Su T: The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma. Eur J Med Res. 19:212014. View Article : Google Scholar : PubMed/NCBI | |
|
Bi H, Li S, Qu X, Wang M, Bai X, Xu Z, Ao X, Jia Z, Jiang X, Yang Y and Wu H: DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase. Cell Death Dis. 6:e18912015. View Article : Google Scholar : PubMed/NCBI | |
|
Sehgal A, Price JL, Man B and Young MW: Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science. 263:1603–1606. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Mazzoccoli G, Laukkanen MO, Vinciguerra M, Colangelo T and Colantuoni V: A timeless link between circadian patterns and disease. Trends Mol Med. 22:68–81. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Parent MÉ, El-Zein M, Rousseau MC, Pintos J and Siemiatycki J: Night work and the risk of cancer among men. Am J Epidemiol. 176:751–759. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Bhatti P, Cushing-Haugen KL, Wicklund KG, Doherty JA and Rossing MA: Nightshift work and risk of ovarian cancer. Occup Environ Med. 70:231–237. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ijaz S, Verbeek J, Seidler A, Lindbohm ML, Ojajärvi A, Orsini N, Costa G and Neuvonen K: Night-shift work and breast cancer-a systematic review and meta-analysis. Scand J Work Environ Health. 39:431–447. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S and Hattori MA: The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells. Physiol Rep. 4:pii:e126632016. View Article : Google Scholar | |
|
Canaple L, Kakizawa T and Laudet V: The days and nights of cancer cells. Cancer Res. 63:7545–7552. 2003.PubMed/NCBI | |
|
Schibler U: The daily timing of gene expression and physiology in mammals. Dialogues Clin Neurosci. 9:257–272. 2007.PubMed/NCBI | |
|
Kornmann B, Schaad O, Bujard H, Takahashi JS and Schibler U: System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 5:e342007. View Article : Google Scholar : PubMed/NCBI | |
|
Walker JR and Hogenesch JB: RNA profiling in circadian biology. Methods Enzymol. 393:366–376. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH and Weitz CJ: Extensive and divergent circadian gene expression in liver and heart. Nature. 417:78–83. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS and Hogenesch JB: Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 109:307–320. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
McCarthy JJ, Andrews JL, McDearmon EL, Campbell KS, Barber BK, Miller BH, Walker JR, Hogenesch JB, Takahashi JS and Esser KA: Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics. 31:86–95. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kornmann B, Preitner N, Rifat D, Fleury-Olela F and Schibler U: Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs. Nucleic Acids Res. 29:E51–E61. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Duffield GE, Best JD, Meurers BH, Bittner A, Loros JJ and Dunlap JC: Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr Biol. 12:551–557. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Lin YM, Chang JH, Yeh KT, Yang MY, Liu TC, Lin SF, Su WW and Chang JG: Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog. 47:925–933. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Yang SL, Yu C, Jiang JX, Liu LP, Fang X and Wu C: Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma. Oncol Lett. 8:2715–2720. 2014.PubMed/NCBI | |
|
Krugluger W, Brandstaetter A, Kállay E, Schueller J, Krexner E, Kriwanek S, Bonner E and Cross HS: Regulation of genes of the circadian clock in human colon cancer: Reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 67:7917–7922. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Hua L, Lu C and Chen Z: Expression of circadian clock gene human Period2 (hPer2) in human colorectal carcinoma. World J Surg Oncol. 9:1662011. View Article : Google Scholar : PubMed/NCBI | |
|
Mazzoccoli G, Panza A, Valvano MR, Palumbo O, Carella M, Pazienza V, Biscaglia G, Tavano F, Di Sebastiano P, Andriulli A and Piepoli A: Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int. 28:841–851. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, Numata K, Shiozawa M, Rino Y, Tanaka K, et al: Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 25:1439–1446. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Yan D, Teng M, Fan J, Zhou C, Li D, Qiu G, Sun X, Li T, Xing T, et al: Reduced expression of PER3 is associated with incidence and development of colon cancer. Ann Surg Oncol. 19:3081–3088. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Karantanos T, Theodoropoulos G, Gazouli M, Vaiopoulou A, Karantanou C, Lymberi M and Pektasides D: Expression of clock genes in patients with colorectal cancer. Int J Biol Markers. 28:280–285. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Chen B, Wang Y, Sun N, Lu C, Qian R and Hua L: hClock gene expression in human colorectal carcinoma. Mol Med Rep. 8:1017–1022. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Yu H, Meng X, Wu J, Pan C, Ying X, Zhou Y, Liu R and Huang W: Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One. 8:e616792013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Xing T, Huang L, Song G, Sun X, Zhong L, Fan J, Yan D, Zhou C, Cui F, et al: Period 1 and estrogen receptor-beta are downregulated in Chinese colon cancers. Int J Clin Exp Pathol. 8:8178–8188. 2015.PubMed/NCBI | |
|
Zhao H, Zeng ZL, Yang J, Jin Y, Qiu MZ, Hu XY, Han J, Liu KY, Liao JW, Xu RH and Zou QF: Prognostic relevance of period1 (Per1) and period2 (Per2) expression in human gastric cancer. Int J Clin Exp Pathol. 7:619–630. 2014.PubMed/NCBI | |
|
Hu ML, Yeh KT, Lin PM, Hsu CM, Hsiao HH, Liu YC, Lin HY, Lin SF and Yang MY: Deregulated expression of circadian clock genes in gastric cancer. BMC Gastroenterol. 14:672014. View Article : Google Scholar : PubMed/NCBI | |
|
Relles D, Sendecki J, Chipitsyna G, Hyslop T, Yeo CJ and Arafat HA: Circadian gene expression and clinicopathologic correlates in pancreatic cancer. J Gastrointest Surg. 17:443–450. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Yu C, Yang SL, Fang X, Jiang JX, Sun CY and Huang T: Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma. Mol Med Rep. 11:4002–4008. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Benegiamo G, Mazzoccoli G, Cappello F, Rappa F, Scibetta N, Oben J, Greco A, Williams R, Andriulli A, Vinciguerra M and Pazienza V: Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes. PLoS One. 8:e605272013. View Article : Google Scholar : PubMed/NCBI | |
|
Kondratov R: Circadian clock and cancer therapy: An unexpected journey. Ann Med. 46:189–190. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Innominato PF, Roche VP, Palesh OG, Ulusakarya A, Spiegel D and Lévi FA: The circadian timing system in clinical oncology. Ann Med. 46:191–207. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Akgun Z, Saglam S, Yucel S, Gural Z, Balik E, Cipe G, Yildiz S, Kilickap S, Okyar A and Kaytan-Saglam E: Neoadjuvant chronomodulated capecitabine with radiotherapy in rectal cancer: A phase II brunch regimen study. Cancer Chemother Pharmacol. 74:751–756. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zarogoulidis P, Darwiche K, Huang H, Spyratos D, Yarmus L, Li Q, Kakolyris S, Syrigos K and Zarogoulidis K: Time recall; future concept of chronomodulating chemotherapy for cancer. Curr Pharm Biotechnol. 14:632–642. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chen D, Cheng J, Yang K, Ma Y and Yang F: Retrospective analysis of chronomodulated chemotherapy versus conventional chemotherapy with paclitaxel, carboplatin, and 5-fluorouracil in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Onco Targets Ther. 6:1507–1514. 2013.PubMed/NCBI |
