Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways

  • Authors:
    • Jun Zhao
    • Yali Li
    • Jinfang Gao
    • Yinshan De
  • View Affiliations

  • Published online on: September 1, 2017     https://doi.org/10.3892/ol.2017.6873
  • Pages: 5569-5574
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Abstract

Hesperidin is a vitamin P flavonoid compound primarily present in citrus fruits. The aim of the present study was to investigate whether hesperidin inhibits ovarian cancer cell viability via endoplasmic reticulum stress signaling pathways. A2780 cells were treated with various doses of hesperidin for 6, 12 or 24 h, and the viability of A2780 cells was assessed using the MTT assay. Hesperidin decreased the viability of A2780 cells and increased cytotoxicity in a dose‑ and time‑dependent manner. In addition, hesperidin induced apoptosis and increased cleaved caspase‑3 protein expression levels in A2780 cells. Furthermore, hesperidin markedly increased the protein expression of anti‑growth arrest‑ and DNA damage‑inducible gene 153, anti‑CCAAT’enhancer‑binding protein homologous protein, glucose‑regulated protein 78 and cytochrome c in A2780 cells. The results of the present study indicated that hesperidin inhibits cell viability and induces apoptosis in ovarian cancer cells via endoplasmic reticulum stress signaling pathways. Thus, hesperidin may offer a novel therapeutic tool for ovarian carcinoma.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao J, Li Y, Gao J and De Y: Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways. Oncol Lett 14: 5569-5574, 2017.
APA
Zhao, J., Li, Y., Gao, J., & De, Y. (2017). Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways. Oncology Letters, 14, 5569-5574. https://doi.org/10.3892/ol.2017.6873
MLA
Zhao, J., Li, Y., Gao, J., De, Y."Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways". Oncology Letters 14.5 (2017): 5569-5574.
Chicago
Zhao, J., Li, Y., Gao, J., De, Y."Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways". Oncology Letters 14, no. 5 (2017): 5569-5574. https://doi.org/10.3892/ol.2017.6873