Function of the macrophage‑capping protein in colorectal carcinoma

  • Authors:
    • Wei Wu
    • Jingdi Chen
    • Qianshan Ding
    • Sheng Yang
    • Jianping Wang
    • Honggang Yu
    • Jun Lin
  • View Affiliations

  • Published online on: September 6, 2017     https://doi.org/10.3892/ol.2017.6888
  • Pages: 5549-5555
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Abstract

To investigate the role of macrophage‑capping protein (CapG) in the development and progression of colorectal carcinoma (CRC), immunohistochemistry (IHC), Kaplan‑Meier survival analysis, wound healing and Transwell migration assays were performed. The IHC results demonstrated that CapG was relatively highly expressed in CRC tissue compared with non‑tumor tissue (P<0.001), and that the expression of CapG was significantly associated with the tumor site, differentiation, lymph node metastasis and clinical stage (P=0.021, P=0.036, P=0.012 and P=0.009, respectively). Wound healing and Transwell migration assays demonstrated that the reduction of CapG expression in a CRC cell line by RNA interference was associated with significantly impaired motility (P<0.001). Kaplan‑Meier survival analysis revealed that the expression of CapG in tumor samples was not significantly associated with disease‑free survival time. In conclusion, CapG was overexpressed in CRC and was associated with tumor progression; therefore, it may be a useful prognostic biomarker and therapeutic target in CRC.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu W, Chen J, Ding Q, Yang S, Wang J, Yu H and Lin J: Function of the macrophage‑capping protein in colorectal carcinoma. Oncol Lett 14: 5549-5555, 2017.
APA
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., & Lin, J. (2017). Function of the macrophage‑capping protein in colorectal carcinoma. Oncology Letters, 14, 5549-5555. https://doi.org/10.3892/ol.2017.6888
MLA
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., Lin, J."Function of the macrophage‑capping protein in colorectal carcinoma". Oncology Letters 14.5 (2017): 5549-5555.
Chicago
Wu, W., Chen, J., Ding, Q., Yang, S., Wang, J., Yu, H., Lin, J."Function of the macrophage‑capping protein in colorectal carcinoma". Oncology Letters 14, no. 5 (2017): 5549-5555. https://doi.org/10.3892/ol.2017.6888