Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases

  • Authors:
    • Jing Liu
    • Yaming Wang
    • Yuantao Liu
    • Zhe Liu
    • Qu Cui
    • Nan Ji
    • Shengjun Sun
    • Bingxu Wang
    • Yajie Wang
    • Xuefei Sun
    • Yuanbo Liu
  • View Affiliations

  • Published online on: September 6, 2017     https://doi.org/10.3892/ol.2017.6893
  • Pages: 5505-5512
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The majority of primary central nervous system lymphomas (PCNSLs) are diffuse large B cell lymphoma, characterized by poor prognosis. In the present study, the expression of cluster of differentiation (CD)10, B cell lymphoma (BCL)‑6, multiple myeloma‑1 (MUM‑1), BCL‑2, CD138 and Ki‑67 was analyzed by immunohistochemistry in 89 Chinese PCNSL cases, and the potential prognostic significance was evaluated. CD10, BCL‑6, MUM‑1, BCL‑2 and CD138 were positive in 16.9 (15/89), 51.7 (46/89), 92.1 (82/89), 73.3 (63/86) and 0% (0/65) of all cases, respectively. According to the Hans algorithm, 71 patients (79.8%) were classified into the non‑germinal center B cell‑like (non‑GCB) group, indicating a post‑germinal center origin of PCNSL. The median follow‑up time of 73 patients was 13 months [95% confidence interval (CI), 10.93‑15.08]. The median overall survival (OS) time was 45.3 months (95% CI, 25.01‑65.59) and the median progression‑free survival (PFS) time was 30.0 months (95% CI, 13.43‑46.57). Age (>60 years) was associated with a shorter OS time (P=0.009). Ki‑67 (cutoff point 90%) was associated with shorter OS (P=0.037) and shorter PFS (P=0.039) times. No other immunohistochemical markers were associated with prognosis. On multivariate analysis, age (>60 years) was associated with shorter OS time (P=0.038), but immunophenotype and expression status of Ki‑67, CD10, BCL‑6 and BCL‑2 did not predict prognosis. In conclusion, high Ki‑67 expression may predict poor prognosis in PCNSL. The present study was limited by its sample size and short follow‑up time. This requires more evidence to further clinical study.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Wang Y, Liu Y, Liu Z, Cui Q, Ji N, Sun S, Wang B, Wang Y, Sun X, Sun X, et al: Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases. Oncol Lett 14: 5505-5512, 2017.
APA
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N. ... Liu, Y. (2017). Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases. Oncology Letters, 14, 5505-5512. https://doi.org/10.3892/ol.2017.6893
MLA
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N., Sun, S., Wang, B., Wang, Y., Sun, X., Liu, Y."Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases". Oncology Letters 14.5 (2017): 5505-5512.
Chicago
Liu, J., Wang, Y., Liu, Y., Liu, Z., Cui, Q., Ji, N., Sun, S., Wang, B., Wang, Y., Sun, X., Liu, Y."Immunohistochemical profile and prognostic significance in primary central nervous system lymphoma: Analysis of 89 cases". Oncology Letters 14, no. 5 (2017): 5505-5512. https://doi.org/10.3892/ol.2017.6893