1
|
Galenkamp K, Carriba P, Urresti J,
Planells-Ferrer L, Coccia E, Lopez-Soriano J, Barneda-Zahonero B,
Moubarak RS, Segura MF and Comella JX: TNFα sensitizes
neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell
death by NF-κB-mediated expression of Fas. Mol Cancer. 14:622015.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Amoroso F, Capece M, Rotondo A, Cangelosi
D, Ferracin M, Franceschini A, Raffaghello L, Pistoia V, Varesio L
and Adinolfi E: The P2X7 receptor is a key modulator of the
PI3K/GSK3β/VEGF signaling network: Evidence in experimental
neuroblastoma. Oncogene. 34:5240–5251. 2015. View Article : Google Scholar : PubMed/NCBI
|
3
|
Cheung NK and Dyer MA: Neuroblastoma:
Developmental biology, cancer genomics and immunotherapy. Nat Rev
Cancer. 13:397–411. 2013. View
Article : Google Scholar : PubMed/NCBI
|
4
|
Dowling RJ, Goodwin PJ and Stambolic V:
Understanding the benefit of metformin use in cancer treatment. BMC
Med. 9:332011. View Article : Google Scholar : PubMed/NCBI
|
5
|
Evans JM, Donnelly LA, Emslie-Smith AM,
Alessi DR and Morris AD: Metformin and reduced risk of cancer in
diabetic patients. BMJ. 330:1304–1305. 2005. View Article : Google Scholar : PubMed/NCBI
|
6
|
Kwong SC and Brubacher J: Phenformin and
lactic acidosis: A case report and review. J Emerg Med. 16:881–886.
1998. View Article : Google Scholar : PubMed/NCBI
|
7
|
Huang X, Wullschleger S, Shapiro N,
McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S and Alessi
DR: Important role of the LKB1-AMPK pathway in suppressing
tumorigenesis in PTEN-deficient mice. Biochem J. 412:211–221. 2008.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Appleyard MV, Murray KE, Coates PJ,
Wullschleger S, Bray SE, Kernohan NM, Fleming S, Alessi DR and
Thompson AM: Phenformin as prophylaxis and therapy in breast cancer
xenografts. Br J Cancer. 106:1117–1122. 2012. View Article : Google Scholar : PubMed/NCBI
|
9
|
Wheaton WW, Weinberg SE, Hamanaka RB,
Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM,
Budigner GS and Chandel NS: Metformin inhibits mitochondrial
complex I of cancer cells to reduce tumorigenesis. Elife.
3:e022422014. View Article : Google Scholar : PubMed/NCBI
|
10
|
Caraci F, Chisari M, Frasca G, Chiechio S,
Salomone S, Pinto A, Sortino MA and Bianchi A: Effects of
phenformin on the proliferation of human tumor cell lines. Life
Sci. 74:643–650. 2003. View Article : Google Scholar : PubMed/NCBI
|
11
|
Martin M and Marais R: Metformin: A
diabetes drug for cancer, or a cancer drug for diabetics? J Clin
Oncol. 30:2698–2700. 2012. View Article : Google Scholar : PubMed/NCBI
|
12
|
Carling D: The AMP-activated protein
kinase cascade-a unifying system for energy control. Trends Biochem
Sci. 29:18–24. 2004. View Article : Google Scholar : PubMed/NCBI
|
13
|
El-Mir MY, Nogueira V, Fontaine E, Avéret
N, Rigoulet M and Leverve X: Dimethylbiguanide inhibits cell
respiration via an indirect effect targeted on the respiratory
chain complex I. J Biol Chem. 275:223–228. 2000. View Article : Google Scholar : PubMed/NCBI
|
14
|
Owen MR, Doran E and Halestrap AP:
Evidence that metformin exerts its anti-diabetic effects through
inhibition of complex 1 of the mitochondrial respiratory chain.
Biochem J 348 Pt. 3:607–614. 2000. View Article : Google Scholar
|
15
|
Miskimins WK, Ahn HJ, Kim JY, Ryu S, Jung
YS and Choi JY: Synergistic anti-cancer effect of phenformin and
oxamate. PLoS ONE. 9:e855762014. View Article : Google Scholar : PubMed/NCBI
|
16
|
Bailey CJ and Turner RC: Metformin. N Engl
J Med. 334:574–579. 1996. View Article : Google Scholar : PubMed/NCBI
|
17
|
Birsoy K, Possemato R, Lorbeer FK,
Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB and
Sabatini DM: Metabolic determinants of cancer cell sensitivity to
glucose limitation and biguanides. Nature. 508:108–112. 2014.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Zhang X, Wang H, Zhang S, Song J, Zhang Y,
Wei X and Feng Z: MiR-134 functions as a regulator of cell
proliferation, apoptosis, and migration involving lung septation.
In Vitro Cell Dev Biol Anim. 48:131–136. 2012. View Article : Google Scholar : PubMed/NCBI
|
19
|
Divakaruni AS, Rogers GW and Murphy AN:
Measuring mitochondrial function in permeabilized cells using the
seahorse XF analyzer or a clark-type oxygen electrode. Curr Protoc
Toxicol. 60(25.2): 1–16. 2014.
|
20
|
Hardie DG, Salt IP and Davies SP: Analysis
of the role of the AMP-activated protein kinase in the response to
cellular stress. Methods Mol Biol. 99:63–74. 2000.PubMed/NCBI
|
21
|
Seo BB, Kitajima-Ihara T, Chan EK,
Scheffler IE, Matsuno-Yagi A and Yagi T: Molecular remedy of
complex I defects: Rotenone-insensitive internal NADH-quinone
oxidoreductase of Saccharomyces cerevisiae mitochondria
restores the NADH oxidase activity of complex I-deficient mammalian
cells. Proc Natl Acad Sci USA. 95:9167–9171. 1998. View Article : Google Scholar : PubMed/NCBI
|
22
|
Seeger RC and Reynolds CP: Treatment of
high-risk solid tumors of childhood with intensive therapy and
autologous bone marrow transplantation. Pediatr Clin North Am.
38:393–424. 1991. View Article : Google Scholar : PubMed/NCBI
|
23
|
Keshelava N, Seeger RC, Groshen S and
Reynolds CP: Drug resistance patterns of human neuroblastoma cell
lines derived from patients at different phases of therapy. Cancer
Res. 58:5396–5405. 1998.PubMed/NCBI
|
24
|
Lennon JC, Bright SA, Carroll E, Butini S,
Campiani G, O'Meara A, Williams DC and Zisterer DM: The novel
pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the
apoptotic effects of carboplatin in drug sensitive and multidrug
resistant neuroblastoma cells. Biochem Pharmacol. 87:611–624. 2014.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Balayssac D, Cayre A, Authier N, Bourdu S,
Penault-Llorca F, Gillet JP, Maublant J, Eschalier A and Coudore F:
Patterns of P-glycoprotein activity in the nervous system during
vincristine-induced neuropathy in rats. J Peripher Nerv Syst.
10:301–310. 2005. View Article : Google Scholar : PubMed/NCBI
|
26
|
Shackelford DB and Shaw RJ: The LKB1-AMPK
pathway: Metabolism and growth control in tumour suppression. Nat
Rev Cancer. 9:563–575. 2009. View Article : Google Scholar : PubMed/NCBI
|
27
|
Goodarzi MO and Bryer-Ash M: Metformin
revisited: Re-evaluation of its properties and role in the
pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab.
7:654–665. 2005. View Article : Google Scholar : PubMed/NCBI
|
28
|
Rizos CV and Elisaf MS: Metformin and
cancer. Eur J Pharmacol. 705:96–108. 2013. View Article : Google Scholar : PubMed/NCBI
|
29
|
Hawley SA, Pan DA, Mustard KJ, Ross L,
Bain J, Edelman AM, Frenguelli BG and Hardie DG:
Calmodulin-dependent protein kinase kinase-beta is an alternative
upstream kinase for AMP-activated protein kinase. Cell Metab.
2:9–19. 2005. View Article : Google Scholar : PubMed/NCBI
|
30
|
Jackson AL, Kilgore JE, Qiu H, Zhou C,
Gehrig PA and Victoria L: Abstract 2442: Antitumorigenic effects of
phenformin in human ovarian cancer cell lines. Cancer Res.
73:24422013. View Article : Google Scholar
|
31
|
Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo
C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC and Zheng
B: Phenformin enhances the therapeutic benefit of BRAF(V600E)
inhibition in melanoma. Proc Natl Acad Sci USA. 110:18226–18231.
2013. View Article : Google Scholar : PubMed/NCBI
|
32
|
Guo Z, Chavez KJ, Alvarez J, Zhang X,
Norris B, Maher M, Morgan M, Schumacher RJ, Cuellar R, Sevrioukova
IF, et al: Abstract 2689: Breast cancer inhibition by a novel and
potent biguanide, N1-hexyl-N5-benzyl-biguanide. Cancer Res.
74:26892014. View Article : Google Scholar
|
33
|
Shackelford DB, Abt E, Gerken L, Vasquez
DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS
and Shaw RJ: LKB1 inactivation dictates therapeutic response of
non-small cell lung cancer to the metabolism drug phenformin.
Cancer Cell. 23:143–158. 2013. View Article : Google Scholar : PubMed/NCBI
|
34
|
Davidoff F: Effects of guanidine
derivatives on mitochondrial function: III. The mechanism of
phenethylbiguanide accumulation and its relationship to in vitro
respiratory inhibition. J Biol Chem. 246:4017–4027. 1971.PubMed/NCBI
|
35
|
Bridges HR, Jones AJ, Pollak MN and Hirst
J: Effects of metformin and other biguanides on oxidative
phosphorylation in mitochondria. Biochem J. 462:475–487. 2014.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Hardie DG: AMPK: A target for drugs and
natural products with effects on both diabetes and cancer.
Diabetes. 62:164–2172. 2013. View Article : Google Scholar
|