Expression of c‑Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection

  • Authors:
    • Chuan Xie
    • Zhen Yang
    • Yi Hu
    • Ximei Cao
    • Jiang Chen
    • Yin Zhu
    • Nonghua Lu
  • View Affiliations

  • Published online on: September 18, 2017     https://doi.org/10.3892/ol.2017.6983
  • Pages: 6151-6155
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Abstract

Activation of the hepatocyte growth factor (HGF)/c‑Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c‑Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 160 H. pylori‑negative and ‑positive patients, including those with chronic gastritis, intestinal metaplasia, dysplasia and gastric cancer (GC). Proteins were extracted from GES‑1, gastric epithelial, and AGS, gastric adenocarcinoma, cells following co‑culture with H. pylori in vitro. The expression of HGF and c‑Met in gastric tissues or cells was determined using immunohistochemistry and western blot analysis. The expression of c‑Met increased in GC tissues (72.5%) compared with that in pre‑cancerous lesions (17.5, 17.5 and 30%). Additional analysis identified that the expression of HGF and c‑Met was significantly increased in the presence of H. pylori infection in dysplasia and gastric cancer samples. Furthermore, H. pylori may activate the HGF/c‑Met signaling pathway in vitro, which may contribute to gastric carcinogenesis.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xie C, Yang Z, Hu Y, Cao X, Chen J, Zhu Y and Lu N: Expression of c‑Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett 14: 6151-6155, 2017.
APA
Xie, C., Yang, Z., Hu, Y., Cao, X., Chen, J., Zhu, Y., & Lu, N. (2017). Expression of c‑Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection. Oncology Letters, 14, 6151-6155. https://doi.org/10.3892/ol.2017.6983
MLA
Xie, C., Yang, Z., Hu, Y., Cao, X., Chen, J., Zhu, Y., Lu, N."Expression of c‑Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection". Oncology Letters 14.5 (2017): 6151-6155.
Chicago
Xie, C., Yang, Z., Hu, Y., Cao, X., Chen, J., Zhu, Y., Lu, N."Expression of c‑Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection". Oncology Letters 14, no. 5 (2017): 6151-6155. https://doi.org/10.3892/ol.2017.6983