Function of insulin‑like growth factor 1 receptor in cancer resistance to chemotherapy (Review)
- Authors:
- Jingsheng Yuan
- Zhijie Yin
- Kaixiong Tao
- Guobing Wang
- Jinbo Gao
-
Affiliations: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China - Published online on: October 26, 2017 https://doi.org/10.3892/ol.2017.7276
- Pages: 41-47
This article is mentioned in:
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|
Cascieri MA and Bayne ML: Analysis of the interaction of IGF-I analogs with the IGF-I receptor and IGF binding proteins. Adv Exp Med Biol. 343:33–40. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, et al: Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. PLoS One. 8:e768222013. View Article : Google Scholar : PubMed/NCBI | |
|
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Amutha P and Rajkumar T: Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer. Indian J Med Paediatr Oncol. 38:198–206. 2017.PubMed/NCBI | |
|
Wan X, Harkavy B, Shen N, Grohar P and Helman LJ: Rapamycin induces feedback activation of akt signaling through an igf-1R-dependent mechanism. Oncogene. 26:1932–1940. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Chen HX and Sharon E: IGF-1R as an anti-cancer target-trials and tribulations. Chin J Cancer. 32:242–252. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Shi WJ and Gao JB: Molecular mechanisms of chemoresistance in gastric cancer. World J Gastrointest Oncol. 8:673–681. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Liu JP, Baker J, Perkins AS, Robertson EJ and Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75:59–72. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Ward CW and Garrett TP: Structural relationships between the insulin receptor and epidermal growth factor receptor families and other proteins. Curr Opin Drug Discov Devel. 7:630–638. 2004.PubMed/NCBI | |
|
Siddle K: The insulin receptor and type I IGF receptor: Comparison of structure and function. Prog Growth Factor Res. 4:301–320. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Wit JM and Walenkamp MJ: Role of insulin-like growth factors in growth, development and feeding. World Rev Nutr Diet. 106:60–65. 2013.PubMed/NCBI | |
|
Yakar S, Kim H, Zhao H, Toyoshima Y, Pennisi P, Gavrilova O and Leroith D: The growth hormone-insulin like growth factor axis revisited: Lessons from IGF-1 and IGF-1 receptor gene targeting. Pediatr Nephrol. 20:251–254. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Russo VC, Gluckman PD, Feldman EL and Werther GA: The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev. 26:916–943. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R and Kahn CR: Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol. 27:1649–1664. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Moody G, Beltran PJ, Mitchell P, Cajulis E, Chung YA, Hwang D, Kendall R, Radinsky R, Cohen P and Calzone FJ: IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 221:145–155. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Delafontaine P, Song YH and Li Y: Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol. 24:435–444. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Gao S, Wassler M, Zhang L, Li Y, Wang J, Zhang Y, Shelat H, Williams J and Geng YJ: MicroRNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis. Atherosclerosis. 232:171–179. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Werner H: Tumor suppressors govern insulin-like growth factor signaling pathways: Implications in metabolism and cancer. Oncogene. 31:2703–2714. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Schayek H, Bentov I, Sun S, Plymate SR and Werner H: Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene. Exp Cell Res. 316:1479–1488. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
O'Connor R, Kauffmann-Zeh A, Liu Y, Lehar S, Evan GI, Baserga R and Blättler WA: Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol Cell Biol. 17:427–435. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Resnicoff M, Abraham D, Yutanawiboonchai W, Rotman HL, Kajstura J, Rubin R, Zoltick P and Baserga R: The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res. 55:2463–2469. 1995.PubMed/NCBI | |
|
Valentinis B and Baserga R: The IGF-I receptor protects tumor cells from apoptosis induced by high concentrations of serum. Biochem Biophys Res Commun. 224:362–368. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Baserga R: The IGF-I receptor in cancer research. Exp Cell Res. 253:1–6. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Samani AA, Yakar S, LeRoith D and Brodt P: The role of the IGF system in cancer growth and metastasis: Overview and recent insights. Endocr Rev. 28:20–47. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Pollak M: The insulin and insulin-like growth factor receptor family in neoplasia: An update. Nat Rev Cancer. 12:159–169. 2012.PubMed/NCBI | |
|
Ter Braak B, Siezen CL, Lee JS, Rao P, Voorhoeve C, Ruppin E, van der Laan JW and van de Water B: Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production. Breast Cancer Res. 19:142017. View Article : Google Scholar : PubMed/NCBI | |
|
Peretz S, Kim C, Rockwell S, Baserga R and Glazer PM: IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Radiat Res. 158:174–180. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Werner H, Sarfstein R, LeRoith D and Bruchim I: Insulin-like growth factor 1 signaling axis meets p53 genome protection pathways. Front Oncol. 6:1592016. View Article : Google Scholar : PubMed/NCBI | |
|
Mamula PW and Goldfine ID: Cloning and characterization of the human insulin-like growth factor-I receptor gene 5′-flanking region. DNA Cell Biol. 11:43–50. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Werner H, Bach MA, Stannard B, Roberts CT Jr and LeRoith D: Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Mol Endocrinol. 6:1545–1558. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Singh RK, Gaikwad SM, Jinager A, Chaudhury S, Maheshwari A and Ray P: IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells. Cancer Lett. 354:254–262. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Schayek H, Bentov I, Rotem I, Pasmanik-Chor M, Ginsberg D, Plymate SR and Werner H: Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Growth Horm IGF Res. 20:68–72. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Huo X, Liu S, Shao T, Hua H, Kong Q, Wang J, Luo T and Jiang Y: GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4. J Biol Chem. 289:24759–72470. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Finkeltov I, Kuhn S, Glaser T, Idelman G, Wright JJ, Roberts CT Jr and Werner H: Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein. Oncogene. 21:1890–1898. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Werner H and Sarfstein R: Transcriptional and epigenetic control of IGF1R gene expression: Implications in metabolism and cance. Growth Horm IGF Res. 24:112–118. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Idelman G, Glaser T, Roberts CT Jr and Werner H: WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation. J Biol Chem. 278:3474–3482. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SO, Park JG and Lee YI: Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: Implications of IGF-I receptor gene activation by hepatitis B virus X gene product. Cancer Res. 56:3831–3836. 1996.PubMed/NCBI | |
|
Taliaferro-Smith L, Oberlick E, Liu T, McGlothen T, Alcaide T, Tobin R, Donnelly S, Commander R, Kline E, Nagaraju GP, et al: FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells. Oncotarget. 6:4757–4772. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Dearth RK, Cui X, Kim HJ, Hadsell DL and Lee AV: Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle. 6:705–713. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Koval AP, Blakesley VA, Roberts CT Jr, Zick Y and Leroith D: Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor. Biochem J. 330:923–932. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Kulik G and Weber MJ: Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol Cell Biol. 18:6711–6718. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Peruzzi F, Prisco M, Dews M, Salomoni P, Grassilli E, Romano G, Calabretta B and Baserga R: Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol. 19:7203–7215. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Brazil DP, Yang ZZ and Hemmings BA: Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci. 29:233–242. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Pollak M: Insulin, insulin-like growth factors and neoplasia. Best Pract Res Clin Endocrinol Metab. 22:625–638. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Greer EL and Brunet A: FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene. 24:7410–7425. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Playford MP, Bicknell D, Bodmer WF and Macaulay VM: Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci USA. 97:pp. 12103–12108. 2000; View Article : Google Scholar : PubMed/NCBI | |
|
Liu C, Zhang Z, Tang H, Jiang Z, You L and Liao Y: Crosstalk between IGF-1R and other tumor promoting pathways. Curr Pharm Des. 20:2912–2921. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rota LM, Albanito L, Shin ME, Goyeneche CL, Shushanov S, Gallagher EJ, LeRoith D, Lazzarino DA and Wood TL: IGF1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors. Cancer Res. 74:5668–5679. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang QY, Wang L, Song ZY and Qu XJ: Knockdown of type I insulin-like growth factor receptor inhibits human colorectal cancer cell growth and downstream PI3K/Akt, WNT/β-catenin signal pathways. Biomed Pharmacother. 73:12–18. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Alsina-Sanchis E, Figueras A, Lahiguera Á, Vidal A, Casanovas O, Graupera M, Villanueva A and Vinals F: The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels. Int J Cancer. 139:1894–4903. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Tognon CE and Sorensen PH: Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opin Ther Targets. 16:33–48. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Firth SM and Baxter RC: Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 23:824–854. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Triplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso GJ, Balasubramanyam S, Chan K, Li L, Chen X, et al: Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation. Proc Natl Acad Sci USA. 113:pp. E1016–E1025. 2016; View Article : Google Scholar : PubMed/NCBI | |
|
Medyouf H, Gusscott S, Wang H, Tseng JC, Wai C, Nemirovsky O, Trumpp A, Pflumio F, Carboni J, Gottardis M, et al: High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med. 208:1809–1822. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Manning BD and Cantley LC: AKT/PKB signaling: Navigating downstream. Cell. 129:1261–1274. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kim EK, Kim JH, Kim HA, Seol H, Seong MK, Lee JY, Byeon J, Sohn YJ, Koh JS, Park IC and Noh WC: Phosphorylated S6 kinase-1: A breast cancer marker predicting resistance to neoadjuvant chemotherapy. Anticancer Res. 33:4073–4079. 2013.PubMed/NCBI | |
|
Sui P, Cao H, Meng L, Hu P, Ma H and Du J: The synergistic effect of humanized monoclonal antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) and chemotherapy. Curr Drug Targets. 15:674–680. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ge J and Chen Z, Wu S, Chen J, Li X, Li J, Yin J and Chen Z: Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer. Digestion. 80:148–158. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
de Groot S, Charehbili A, van Laarhoven HW, Mooyaart AL, Dekker-Ensink NG, van de Ven S, Janssen LG, Swen JJ, Smit VT, Heijns JB, et al: Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: Results from the NEOZOTAC trial (BOOG 2010-01). Breast Cancer Res. 18:32016. View Article : Google Scholar : PubMed/NCBI | |
|
Sun HZ, Wu SF and Tu ZH: Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated cytotoxicity. Cell Res. 11:107–115. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Thomas F, Holly JM, Persad R, Bahl A and Perks CM: Fibronectin confers survival against chemotherapeutic agents but not against radiotherapy in DU145 prostate cancer cells: involvement of the insulin like growth factor-1 receptor. Prostate. 70:856–865. 2010.PubMed/NCBI | |
|
Eckstein N, Servan K, Hildebrandt B, Pölitz A, von Jonquières G, Wolf-Kümmeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, et al: Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 69:2996–3003. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Montazami N, Aghapour M, Farajnia S and Baradaran B: New insights into the mechanisms of multidrug resistance in cancers. Cell Mol Biol (Noisy-le-grand). 61:70–80. 2015.PubMed/NCBI | |
|
Worrall C, Nedelcu D, Serly J, Suleymanova N, Oprea I, Girnita A and Girnita L: Novel mechanisms of regulation of IGF-1R action: Functional and therapeutic implications. Pediatr Endocrinol Rev. 10:473–484. 2013.PubMed/NCBI | |
|
Chen MY, Clark AJ, Chan DC, Ware JL, Holt SE, Chidambaram A, Fillmore HL and Broaddus WC: Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: A potential role for IGF-1R de-repression. J Neurooncol. 103:87–102. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Qian X, Yu J, Yin Y, He J, Wang L, Li Q, Zhang LQ, Li CY, Shi ZM, Xu Q, et al: MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers. Cell Cycle. 12:1385–1394. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Ge G, Ding Y, Zhou X, Huang Z, Zhu W, Shu Y and Liu P: MiR-503 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R and BCL2. Chin Med J (Engl). 127:2357–2362. 2014.PubMed/NCBI | |
|
Yang M, Shan X, Zhou X, Qiu T, Zhu W, Ding Y, Shu Y and Liu P: miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2. Anticancer Agents Med Chem. 14:884–891. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhuang M, Shi Q, Zhang X, Ding Y, Shan L, Shan X, Qian J, Zhou X, Huang Z, Zhu W, et al: Involvement of miR-143 in cisplatin resistance of gastric cancer cells via targeting IGF1R and BCL2. Tumour Biol. 36:2737–2745. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Verhagen HJ, de Leeuw DC, Roemer MG, Denkers F, Pouwels W, Rutten A, Celie PH, Ossenkoppele GJ, Schuurhuis GJ and Smit L: IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. Cell Death Dis. 5:e13002014. View Article : Google Scholar : PubMed/NCBI | |
|
Baxter RC: Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol Endocrinol Metab. 278:E967–E976. 2000.PubMed/NCBI | |
|
Bach LA: Insulin-like growth factor binding proteins-an update. Pediatr Endocrinol Rev. 13:521–530. 2015.PubMed/NCBI | |
|
Beattie J, Allan GJ, Lochrie JD and Flint DJ: Insulin-like growth factor-binding protein-5 (IGFBP-5): A critical member of the IGF axis. Biochem J. 395:1–19. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Beech DJ, Perer E, Helms J, Gratzer A and Deng N: Insulin-like growth factor-I receptor activation blocks doxorubicin cytotoxicity in sarcoma cells. Oncol Rep. 10:181–184. 2003.PubMed/NCBI | |
|
Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, van Buren G II, Samuel S, Kim MP, Lim SJ and Ellis LM: Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 69:1951–1957. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Y, Zheng S, Torossian A, Speirs CK, Schleicher S, Giacalone NJ, Carbone DP, Zhao Z and Lu B: Role of insulin-like growth factor-1 signaling pathway in cisplatin-resistant lung cancer cells. Int J Radiat Oncol Biol Phys. 82:e563–e572. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kim TR, Cho EW, Paik SG and Kim IG: Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy. FEBS Lett. 586:303–309. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Werner H and Le Roith D: New concepts in regulation and function of the insulin-like growth factors: Implications for understanding normal growth and neoplasia. Cell Mol Life Sci. 57:932–942. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Tracz AF, Szczylik C, Porta C and Czarnecka AM: Insulin-like growth factor-1 signaling in renal cell carcinoma. BMC Cancer. 16:4532016. View Article : Google Scholar : PubMed/NCBI | |
|
Buck E and Mulvihill M: Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin Investig Drugs. 20:605–621. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ozaki T and Nakagawara A: P53: The attractive tumor suppressor in the cancer research field. J Biomed Biotechnol. 2011:6039252011. View Article : Google Scholar : PubMed/NCBI | |
|
Larsson O, Girnita A and Girnita L: Role of insulin-like growth factor 1 receptor signalling in cancer. Br J Cancer. 96 Suppl:R2–R6. 2007.PubMed/NCBI | |
|
Adams JM and Cory S: Bcl-2-regulated apoptosis: Mechanism and therapeutic potential. Curr Opin Immunol. 19:488–496. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kashyap MK: Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers. Tumour Biol. 36:8247–8257. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang ZS, Sun YZ, Wang SM and Ruan JS: Epithelial-mesenchymal transition: Potential regulator of ABC transporters in tumor progression. J Cancer. 8:2319–2327. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang YK, Wang YJ, Gupta P and Chen ZS: Multidrug resistance proteins (MRPs) and cancer therapy. AAPS J. 17:802–812. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Benabbou N, Mirshahi P, Bordu C, Faussat AM, Tang R, Therwath A, Soria J, Marie JP and Mirshahi M: A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell line. Int J Oncol. 45:1372–1380. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Shen K, Cui D, Sun L, Lu Y, Han M and Liu J: Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression. J Cell Biochem. 113:2086–2097. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Benabbou N, Mirshahi P, Cadillon M, Soria J, Therwath A and Mirshahi M: Hospicells promote upregulation of the ATP-binding cassette genes by insulin-like growth factor-I via the JAK2/STAT3 signaling pathway in an ovarian cancer cell line. Int J Oncol. 43:685–694. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Gilkes DM, Semenza GL and Wirtz D: Hypoxia and the extracellular matrix: Drivers of tumour metastasis. Nat Rev Cancer. 14:430–439. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Elliott T and Sethi T: Integrins and extracellular matrix: A novel mechanism of multidrug resistance. Expert Rev Anticancer Ther. 2:449–459. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
L Addison C: Modulation of response to tumor therapies by the extracellular matrix. Future Oncol. 2:417–429. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Sayeed A, Fedele C, Trerotola M, Ganguly KK and Languino LR: IGF-IR promotes prostate cancer growth by stabilizing α5β1 integrin protein levels. PLoS One. 8:e765132013. View Article : Google Scholar : PubMed/NCBI | |
|
Prokop I, Konończuk J, Surażyński A and Pałka J: Cross-talk between integrin receptor and insulin-like growth factor receptor in regulation of collagen biosynthesis in cultured fibroblasts. Adv Med Sci. 58:292–297. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Packham S, Warsito D, Lin Y, Sadi S, Karlsson R, Sehat B and Larsson O: Nuclear translocation of IGF-1R via p150(Glued) and an importin-β/RanBP2-dependent pathway in cancer cells. Oncogene. 34:2227–2238. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Aleksic T, Chitnis MM, Perestenko OV, Gao S, Thomas PH, Turner GD, Protheroe AS, Howarth M and Macaulay VM: Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res. 70:6412–6419. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sehat B, Tofigh A, Lin Y, Trocmé E, Liljedahl U, Lagergren J and Larsson O: SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor. Sci Signal. 3:ra102010. View Article : Google Scholar : PubMed/NCBI | |
|
Sarfstein R, Pasmanik-Chor M, Yeheskel A, Edry L, Shomron N, Warman N, Wertheimer E, Maor S, Shochat L and Werner H: Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. J Biol Chem. 287:2766–2776. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Vesel M, Rapp J, Feller D, Kiss E, Jaromi L, Meggyes M, Miskei G, Duga B, Smuk G, Laszlo T, et al: ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling. Respir Res. 18:522017. View Article : Google Scholar : PubMed/NCBI | |
|
Huang YH, Lin MH, Wang PC, Wu YC, Chiang HL, Wang YL, Chang JH, Huang YK, Gu SY, Ho HN and Ling TY: Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol Hum Reprod. 20:526–537. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Treins C, Giorgetti-Peraldi S, Murdaca J, Monthouël-Kartmann MN and Van Obberghen E: Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. Mol Endocrinol. 19:1304–1317. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Popeda M, Pluciennik E and Bednarek AK: Proteins in cancer multidrug resistance. Postepy Hig Med Dosw (Online). 68:616–632. 2014.(In Polish). View Article : Google Scholar : PubMed/NCBI | |
|
Genois MM, Paquet ER, Laffitte MC, Maity R, Rodrigue A, Ouellette M and Masson JY: DNA repair pathways in trypanosomatids: From DNA repair to drug resistance. Microbiol MoI Biol Rev. 78:40–73. 2014. View Article : Google Scholar |
