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Modified vs. standard D2 lymphadenectomy in distal subtotal gastrectomy for locally advanced gastric cancer patients under 70 years of age

  • Authors:
    • Chun‑Dong Zhang
    • Liang Zong
    • Fei‑Long Ning
    • Xian‑Tao Zeng
    • Dong‑Qiu Dai

  • View Affiliations

  • Published online on: October 26, 2017     https://doi.org/10.3892/ol.2017.7277
  • Pages: 375-385

  • Copyright : © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The present study was conducted to investigate the prognosis and survival of patients with locally advanced gastric cancer who underwent distal subtotal gastrectomy with modified D2 (D1+) and D2 lymphadenectomy, under 70 years of age. The five‑year overall survival rates of 390 patients were compared between those receiving D1+ and D2 lymphadenectomy. Univariate and multivariate analyses were used to identify factors that correlated with prognosis and lymph node metastasis. Tumor size (P=0.039), pT stage (P=0.011), pN stage (P<0.001), and lymphadenectomy (P=0.004) were identified as independent prognostic factors. Furthermore, tumor size (P=0.022), pT stage (P=0.012), and lymphadenectomy (P=0.028) were proven as independent factors predicting lymph node metastasis. In conclusion, cancers of larger size, higher pT stage, and with D1+ lymphadenectomy had a higher risk of lymph node metastasis. Standard D2 lymphadenectomy removes sufficient lymph nodes to improve staging accuracy and survival. Therefore, D2 lymphanectomy is recommended in distal subtotal gastrectomy for locally advanced gastric cancer, especially for cancers of larger size and higher pT stage.
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January-2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang CD, Zong L, Ning FL, Zeng XT and Dai DQ: Modified vs. standard D2 lymphadenectomy in distal subtotal gastrectomy for locally advanced gastric cancer patients under 70 years of age. Oncol Lett 15: 375-385, 2018.
APA
Zhang, C., Zong, L., Ning, F., Zeng, X., & Dai, D. (2018). Modified vs. standard D2 lymphadenectomy in distal subtotal gastrectomy for locally advanced gastric cancer patients under 70 years of age. Oncology Letters, 15, 375-385. https://doi.org/10.3892/ol.2017.7277
MLA
Zhang, C., Zong, L., Ning, F., Zeng, X., Dai, D."Modified vs. standard D2 lymphadenectomy in distal subtotal gastrectomy for locally advanced gastric cancer patients under 70 years of age". Oncology Letters 15.1 (2018): 375-385.
Chicago
Zhang, C., Zong, L., Ning, F., Zeng, X., Dai, D."Modified vs. standard D2 lymphadenectomy in distal subtotal gastrectomy for locally advanced gastric cancer patients under 70 years of age". Oncology Letters 15, no. 1 (2018): 375-385. https://doi.org/10.3892/ol.2017.7277