Validation of the novel susceptibility loci for prostate cancer in a Chinese population

Wu,Yishuo; Chen,Haitao; Ji,Ying; Na,Rong; Mo,Zengnan; Ye,Dingwei; Wang,Meilin; Qi,Jun; Lin,Xiaoling; Ding,Qiang; Xu,Jianfeng; Zheng,S.   Lilly; Sun,Yinghao; Meng,Wei

doi:10.3892/ol.2017.7602

Validation of the novel susceptibility loci for prostate cancer in a Chinese population

Authors:
- Yishuo Wu
- Haitao Chen
- Ying Ji
- Rong Na
- Zengnan Mo
- Dingwei Ye
- Meilin Wang
- Jun Qi
- Xiaoling Lin
- Qiang Ding
- Jianfeng Xu
- S. Lilly Zheng
- Yinghao Sun
- Wei Meng
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Affiliations: Department of Urology, Huashan Hospital, Fudan University, Shanghai 200000, P.R. China, Center for Genomic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai 200000, P.R. China, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Department of Urology, Shanghai Cancer Center, Fudan University, Shanghai 200000, P.R. China, Department of Molecular and Genetic Toxicology, The Key Laboratory of Modern Toxicology of The Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Urology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, P.R. China, Urology Research Center, Fudan University, Shanghai 200000, P.R. China, Program for Personalized Cancer Care, NorthShore University Health System, Evanston, IL 60201, USA, Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200000, P.R. China, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200000, P.R. China
Published online on: December 13, 2017 https://doi.org/10.3892/ol.2017.7602
Pages: 2567-2573

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Abstract

The present study evaluated 23 newly identified susceptibility loci for prostate cancer (PCa) in a Chinese population and assessed whether any validated loci were associated with the genetic risk score (GRS) of PCa in a Chinese population. A total of 1,417 patients with PCa and 1,008 controls were recruited in the present study. The association of each single nucleotide polymorphism (SNP) with PCa risk and PCa aggressiveness was analyzed. The predictive ability of two GRSs based on 30 SNPs (GRS30) and the 9 most significant SNPs (GRS9) in the Chinese population were also compared. Among the 19 SNPs evaluated, 1 SNP (rs7153648 at 14q23) was associated with PCa risk [odds ratio (OR)=1.206, P<0.05)] and 1 SNP (rs636291 at 1p23) was associated with PCa aggressiveness (OR=1.123, P<0.05). GRS30 and GRS9 were significantly increased in patients with PCa compared with that among non‑PCa controls. The areas under receiver operating characteristic curves of GRS9 and GRS 30 were similar (0.792 for GRS9 vs. 0.7994 for GRS30, P=0.138). To conclude, among the 19 SNPs evaluated, only 1 SNP was associated with PCa risk in the Chinese population. SNPs that were weakly associated with PCa were unlikely to improve the predictive ability of existing GRS in the Chinese population.

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