Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway

  • Authors:
    • Li Guo
    • Xiaohong Wang
    • Yuguang Yang
    • Hongchun Xu
    • Zhihong Zhang
    • Lili Yin
    • Yan Wang
    • Maopeng Yang
    • Shu Zhao
    • Shuping Bai
    • Ling Zhao
    • Zhipeng Wang
    • Xin Lian
    • Ying Liu
    • Qingyuan Zhang
  • View Affiliations

  • Published online on: December 18, 2017     https://doi.org/10.3892/ol.2017.7633
  • Pages: 3287-3294
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Abstract

The activation of the Wnt/β‑catenin signaling pathway has been demonstrated to play important roles in breast carcinogenesis and to be associated with a poorer prognosis in breast cancer patients. However, genetic mutation is not the major reason for Wnt/β‑catenin activation in breast cancer. Dishevelled‑associated antagonist of β‑catenin homolog 2 (DACT2) is a negative regulator of β‑catenin and acts as a tumor suppressor in numerous cancer types; however, the expression change and potential role of DACT2 in breast cancer is unknown. The present study detected the expression and function of DACT2 in breast cancer progression. It was identified that the expression of DACT2 significantly decreased in breast cancer tissues compared with paired adjacent normal breast tissues. Additional investigation demonstrated that the hypermethylation of DACT2 gene promoter contributes to the loss of the gene in breast cancer. It was also demonstrated that DACT2 is a tumor suppressor in breast cancer and inhibits the proliferation and invasion of breast cancer cells by repressing the expression of β‑catenin target genes associated with tumor growth and metastasis. The present study indicates that the loss of DACT2 may contribute to breast cancer progression and provides a promising therapeutic target for the treatment of breast cancer.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Guo L, Wang X, Yang Y, Xu H, Zhang Z, Yin L, Wang Y, Yang M, Zhao S, Bai S, Bai S, et al: Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway. Oncol Lett 15: 3287-3294, 2018.
APA
Guo, L., Wang, X., Yang, Y., Xu, H., Zhang, Z., Yin, L. ... Zhang, Q. (2018). Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway. Oncology Letters, 15, 3287-3294. https://doi.org/10.3892/ol.2017.7633
MLA
Guo, L., Wang, X., Yang, Y., Xu, H., Zhang, Z., Yin, L., Wang, Y., Yang, M., Zhao, S., Bai, S., Zhao, L., Wang, Z., Lian, X., Liu, Y., Zhang, Q."Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway". Oncology Letters 15.3 (2018): 3287-3294.
Chicago
Guo, L., Wang, X., Yang, Y., Xu, H., Zhang, Z., Yin, L., Wang, Y., Yang, M., Zhao, S., Bai, S., Zhao, L., Wang, Z., Lian, X., Liu, Y., Zhang, Q."Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway". Oncology Letters 15, no. 3 (2018): 3287-3294. https://doi.org/10.3892/ol.2017.7633