Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer

  • Authors:
    • Peiguang Niu
    • Daohua Shi
    • Shusheng Zhang
    • Yanting Zhu
    • Jintuo Zhou
  • View Affiliations

  • Published online on: January 8, 2018     https://doi.org/10.3892/ol.2018.7743
  • Pages: 3991-3997
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The mammalian target of rapamycin (mTOR) is well-known as a promising therapeutic target in various cancer cells. mTOR activation decreases the sensitivity of ovarian cancer to cisplatin. Cardamonin inhibits the proliferation of various cancer cells by mTOR suppression. The present study examined whether cardamonin combined with cisplatin is efficacious for the anti‑proliferation of ovarian cancer cells. The anti‑proliferative effect was determined by MTT and cell cycle assays. Activation of the mTOR signal pathway and the expression of anti‑apoptotic proteins were evaluated by western blot analysis. Cardamonin significantly enhanced the effects of cisplatin on cell proliferation and cell cycle progression. The expression of B cell lymphoma‑2, X‑linked inhibitor of apoptosis protein and Survivin was significantly decreased following combination treatment. Furthermore, the activation of mTOR and its downstream 70 kDa ribosomal protein S6 kinase was inhibited by cardamonin. These results demonstrated that the combinatorial effects of cardamonin and cisplatin on anti-proliferation were enhanced by suppressing the expression of anti‑apoptotic proteins and activation of mTOR in ovarian cancer cells.
View Figures
View References

Related Articles

Journal Cover

March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Niu P, Shi D, Zhang S, Zhu Y and Zhou J: Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer. Oncol Lett 15: 3991-3997, 2018.
APA
Niu, P., Shi, D., Zhang, S., Zhu, Y., & Zhou, J. (2018). Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer. Oncology Letters, 15, 3991-3997. https://doi.org/10.3892/ol.2018.7743
MLA
Niu, P., Shi, D., Zhang, S., Zhu, Y., Zhou, J."Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer". Oncology Letters 15.3 (2018): 3991-3997.
Chicago
Niu, P., Shi, D., Zhang, S., Zhu, Y., Zhou, J."Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer". Oncology Letters 15, no. 3 (2018): 3991-3997. https://doi.org/10.3892/ol.2018.7743