Open Access

Expression and clinical significance of serum MMP‑7 and PTEN levels in patients with acute myeloid leukemia

  • Authors:
    • Jiang Wu
    • Yu Song
  • View Affiliations

  • Published online on: January 15, 2018     https://doi.org/10.3892/ol.2018.7799
  • Pages: 3447-3452
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to examine the changes of serum matrix metalloproteinase‑7 (MMP‑7) and phosphatase and tension homolog (PTEN) in patients with acute myeloid leukemia (AML) at different time points following treatment. The levels of serum MMP‑7 and PTEN were measured from 80 AML patients with a diagnosis of peripheral blood, immune cell phenotype, and bone marrow puncture cytology examination. Among these, there were 20 cases of complete remission, 20 cases of primary untreated patients, 21 cases of incomplete remission, and 19 cases of relapse after remission. In addition, 20 healthy adults with normal physical examination results were enrolled as the control group. Patients were divided into different groups according to the treatment period. Serum MMP‑7 and PTEN levels in patients and the healthy control group were measured using an ELISA. Compared with the control group, the levels of MMP‑7 of 20 primary untreated patients were significantly increased (P<0.05), while there was no significant difference for the levels of PTEN in the incomplete remission group. A comparison between the control and complete remission groups revealed that the levels of MMP‑7 and PTEN in the serum samples of 21 cases of patients with incomplete remission were significantly increased (P<0.05). In addition, the content of MMP‑7 in 19 patients in relapse after remission group was significantly higher (P<0.05) than that of the complete remission and healthy control groups, while the levels of serum PTEN did not show significant changes. In conclusion, the level of serum MMP‑7 and PTEN in AML patients was closely related to the clinical stage and the degree of disease. The combination of MMP‑7 and PTEN may provide theoretical support for the accurate diagnosis, understanding of efficacy, prognosis and improvement of survival rate of AML.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu J and Song Y: Expression and clinical significance of serum MMP‑7 and PTEN levels in patients with acute myeloid leukemia. Oncol Lett 15: 3447-3452, 2018.
APA
Wu, J., & Song, Y. (2018). Expression and clinical significance of serum MMP‑7 and PTEN levels in patients with acute myeloid leukemia. Oncology Letters, 15, 3447-3452. https://doi.org/10.3892/ol.2018.7799
MLA
Wu, J., Song, Y."Expression and clinical significance of serum MMP‑7 and PTEN levels in patients with acute myeloid leukemia". Oncology Letters 15.3 (2018): 3447-3452.
Chicago
Wu, J., Song, Y."Expression and clinical significance of serum MMP‑7 and PTEN levels in patients with acute myeloid leukemia". Oncology Letters 15, no. 3 (2018): 3447-3452. https://doi.org/10.3892/ol.2018.7799