Molecular background of the regional lymph node metastasis of gastric cancer (Review)
- Authors:
- Tong Zhu
- Xueqian Hu
- Pinkang Wei
- Guangzhi Shan
-
Affiliations: Department of Oncology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China, Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Ningbo, Zhejiang 315000, P.R. China, Department of Traditional Chinese Medicine, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China - Published online on: January 16, 2018 https://doi.org/10.3892/ol.2018.7813
- Pages: 3409-3414
This article is mentioned in:
Abstract
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lianos GD, Rausei S, Ruspi L, Galli F, Mangano A, Roukos DH, Dionigi G and Boni L: Laparoscopic gastrectomy for gastric cancer: Current evidences. Int J Surg. 12:1369–1373. 2014. View Article : Google Scholar : PubMed/NCBI | |
de Boer M, van Dijck JA, Bult P, Borm GF and Heijnen VC: Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases. J Natl Cancer Inst. 102:410–425. 2010. View Article : Google Scholar : PubMed/NCBI | |
Deng JY and Liang H: Clinical significance of lymph node metastasis in gastric cancer. World J Gastroenterol. 20:3967–3975. 2014. View Article : Google Scholar : PubMed/NCBI | |
Velho S, Fernandes MS, Leite M, Figueiredo C and Seruca R: Causes and consequences of microsatellite instability in gastric carcinogenesis. World J Gastroenterol. 20:16433–16442. 2014. View Article : Google Scholar : PubMed/NCBI | |
Paz H, Pathak N and Yang J: Invading one step at a time: The role of invadopodia in tumor metastasis. Oncogene. 33:4193–4202. 2014. View Article : Google Scholar : PubMed/NCBI | |
Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 3:161–174. 2002. View Article : Google Scholar | |
de la Peña S, Sampieri CL, Ochoa-Lara M, León-Córdoba K and Remes-Troche JM: Expression of the matrix metalloproteases 2, 14, 24 and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer. Dis Markers. 2014:2859062014. View Article : Google Scholar : PubMed/NCBI | |
Lu PF, Weaver VM and Werb Z: The extracellular matrix: A dynamic niche in cancer progression. J Cell Biol. 196:395–406. 2012. View Article : Google Scholar : PubMed/NCBI | |
Dey S, Ghosh N, Saha D, Kesh K, Gupta A and Swarnakar S: Matrix metalloproteinase-1 (MMP-1) promoter polymorphisms are well linked with lower stomach tumor formation in eastern Indian population. PLoS One. 9:e880402014. View Article : Google Scholar : PubMed/NCBI | |
Shen WS, Xi HQ, Wei B and Chen L: The prognostic role of matrix metalloproteinase 2 in gastric cancer: A systematic review with meta-analysis. J Cancer Res Clin Oncol. 140:1003–1009. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mimori K, Fukagawa T, Kosaka Y, Ishikawa K, Iwatsuki M, Yokobori T, Hirasaki S, Takatsuno Y, Sakashita H, Ishii H, et al: A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases. Ann Surg Oncol. 15:2934–2942. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ninomiya T, Yoon S, Nagano H, Kumon Y, Seo Y, Kasuga M, Yano Y, Nakaji M and Hayashi Y: Significance of serum matrix metalloproteinases and their inhibitors on the antifibrogenetic effect of interferon-alfa in chronic hepatitis C patients. Intervirology. 44:227–231. 2001. View Article : Google Scholar : PubMed/NCBI | |
Nuttall RK, Sampieri CL, Pennington CJ, Gill SE, Schultz GA and Edwards DR: Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. FEBS Lett. 563:129–134. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kemik O, Kemik AS, Sümer A, Dulger AC, Adas M, Begenik H, Hasirci I, Yilmaz O, Purisa S, Kisli E, et al: Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer. World J Gastroenterol. 17:2109–2112. 2011. View Article : Google Scholar : PubMed/NCBI | |
Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M, et al: Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology. 136:663–672.e4. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yoo EJ, Park SY, Cho NY, Kim N, Lee HS and Kang GH: Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks. Virchows Arch. 452:514–524. 2008. View Article : Google Scholar | |
Shin SH, Park SY, Ko JS, Kim N and Kang GH: Aberrant CpG island hypermethylation in pediatric gastric mucosa in association with Helicobacter pylori infection. Arch Pathol Lab Med. 135:759–765. 2011.PubMed/NCBI | |
Yu JL, Lv P, Han J, Zhu X, Hong LL, Zhu WY, Wang XB, Wu YC, Li P and Ling ZQ: Methylated TIMP-3 DNA in body fluids is an independent prognostic factor for gastric cancer. Arch Pathol Lab Med. 138:1466–1473. 2014. View Article : Google Scholar : PubMed/NCBI | |
Rocks N, Paulissen G, El Hour M, Quesada F, Crahay C, Gueders M, Foidart JM, Noel A and Cataldo D: Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. Biochimie. 90:369–379. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kim KE, Song H, Hahm C, Yoon SY, Park S, Lee HR, Hur DY, Kim T, Kim CH, Bang SI, et al: Expression of ADAM33 is a novel regulatory mechanism in IL-18-secreted process in gastric cancer. J Immunol. 182:3548–3555. 2009. View Article : Google Scholar : PubMed/NCBI | |
Carl-McGrath S, Lendeckel U, Ebert M, Roessner A and Röcken C: The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 26:17–24. 2005.PubMed/NCBI | |
Folkman J: The role of angiogenesis in tumor growth. Semin Cancer Biol. 3:65–71. 1992.PubMed/NCBI | |
Vermeulen PB, van Golen KL and Dirix LY: Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: A review of the current knowledge. Cancer. 116 11 Suppl:S2748–S2754. 2010. View Article : Google Scholar | |
Raica M and Ribatti D: Targeting tumor lymphangiogenesis: An update. Curr Med Chem. 17:698–708. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kostis G, Ioannis L, Helen K and Helen P: The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study. Urol Ann. 6:224–230. 2014. View Article : Google Scholar : PubMed/NCBI | |
Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP and Jain RK: Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: Therapeutic implications. Cancer Res. 66:8065–8075. 2006. View Article : Google Scholar : PubMed/NCBI | |
Harris NC, Davydova N, Roufail S, Paquet-Fifield S, Paavonen K, Karnezis T, Zhang YF, Sato T, Rothacker J, Nice EC, et al: The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem. 288:8176–8186. 2013. View Article : Google Scholar : PubMed/NCBI | |
Aoyagi K, Kouhuji K, Miyagi M, Kizaki J, Isobe T, Hashimoto K and Shirouzu K: Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer. World J Crit Care Med. 2:48–55. 2013. View Article : Google Scholar : PubMed/NCBI | |
Shah MA, Jhawer M, Ilson DH, Lefkowitz RA, Robinson E, Capanu M and Kelsen DP: Phase II study of modified docetaxel, cisplatin, and fluorouracil with bevacizumab in patients with metastatic gastroesophageal adenocarcinoma. J Clin Oncol. 29:868–874. 2011. View Article : Google Scholar : PubMed/NCBI | |
Ohtsu A, Shah MA, Van Cutsem E, Rha SY, Sawaki A, Park SR, Lim HY, Yamada Y, Wu J, Langer B, et al: Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study. J Clin Oncol. 29:3968–3976. 2011. View Article : Google Scholar : PubMed/NCBI | |
Shah MA, Ramanathan RK, Ilson DH, Levnor A, D'Adamo D, O'Reilly E, Tse A, Trocola R, Schwartz L, Capanu M, et al: Multicenter phase II study of irinotecan, cisplatin and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. J Clin Oncol. 24:5201–5206. 2006. View Article : Google Scholar : PubMed/NCBI | |
Gou HF, Chen XC, Zhu J, Jiang M, Yang Y, Cao D and Hou M: Expressions of COX-2 and VEGF-C in gastric cancer: Correlations with lymphangiogenesis and prognostic implications. J Exp Clin Cancer Res. 30:142011. View Article : Google Scholar : PubMed/NCBI | |
Botting SK, Fouad H, Elwell K, Rampy BA, Salama SA, Freeman DH and Diaz-Arrastia CR: Prognostic significance of peritumoral lymphatic vessel density and vascular endothelial growth factor receptor 3 in invasive squamous cell cervical cancer. Transl Oncol. 3:170–175. 2010. View Article : Google Scholar : PubMed/NCBI | |
Cao R, Björndahl MA, Religa P, Clasper S, Garvin S, Galter D, Meister B, Ikomi F, Tritsaris K, Dissing S, et al: PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell. 6:333–345. 2004. View Article : Google Scholar : PubMed/NCBI | |
Björndahl M, Cao R, Nissen LJ, Clasper S, Johnson LA, Xue Y, Zhou Z, Jackson D, Hansen A and Cao YH: Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci USA. 102:pp. 15593–15598. 2005; View Article : Google Scholar : PubMed/NCBI | |
Platonova N, Miquel G, Regenfuss B, Taouji S, Cursiefen S, Chevet E and Bikfalvi A: Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1. Blood. 121:1229–1237. 2013. View Article : Google Scholar : PubMed/NCBI | |
Schulz MM, Reisen F, Zgraggen S, Fischer S, Yuen D, Kang GJ, Chen L, Schneider G and Detmar M: Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci USA. 109:pp. E2665–E2674. 2012; View Article : Google Scholar : PubMed/NCBI | |
Cao R, Björndahl MA, Gallego MI, Chen S, Religa P, Hansen AJ and Cao Y: Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood. 107:3531–3536. 2006. View Article : Google Scholar : PubMed/NCBI | |
Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, et al: Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst. 104:461–475. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sumida H, Yanagida K, Kita Y, Abe J, Matsushima K, Nakamura M, Ishii S, Sato S and Shimizu T: Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis. J Immunol. 192:4361–4369. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chiba F, Soda K, Yamada S, Tokutake Y, Chohnan S and Konishi F: The importance of tissue environment surrounding the tumor on the development of cancer cachexia. Int J Oncol. 44:177–186. 2014. View Article : Google Scholar : PubMed/NCBI | |
Cheng WL, Wang CS, Huang YH, Tsai MM, Liang Y and Lin KH: Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer. Ann Oncol. 22:2267–2276. 2011. View Article : Google Scholar : PubMed/NCBI | |
Xiang Z, Zhou ZJ, Xia GK, Zhang XH, Wei ZW, Zhu JT, Yu J, Chen W, He Y, Schwarz RE, et al: A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis. Oncogene. 34:5122–5133. 2015. | |
Itakura M, Tokuda A, Kimura H, Nagai S, Yoneyama H, Onai N, Ishikawa S, Kuriyama T and Matsushima K: Blockade of secondary lymphoid tissue chemokine exacerbatesPropionibacterium acnes-induced acute lung inflammation. J Immunol. 3:2071–2079. 2001. View Article : Google Scholar | |
Du P, Liu Y, Ren H, Zhao J, Zhang X, Patel R, Hu C, Gan J and Huang G: Expression of chemokine receptor CCR7 is a negative prognostic factor for patients with gastric cancer: A meta-analysis. Gastric Cancer. 20:235–245. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ma H, Gao L, Li S, Qin J, Chen L, Liu X, Xu P, Wang F, Xiao H, Zhou S, et al: CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer. Oncotarget. 6:24348–24360. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, Zhou Y and Yang Y: CCR7 pathway induces epithelial-mesenchymal transition through up-regulation of Snail signaling in gastric cancer. Med Oncol. 32:4672015.PubMed/NCBI | |
Vela M, Aris M, Llorente M, Garcia-Sanz JA and Kremer L: Chemokine receptor-specific antibodies in cancer immunotherapy: Achievements and challenges. Front Immunol. 6:122015. View Article : Google Scholar : PubMed/NCBI | |
Le Bras GF, Taubenslag KJ and Andl CD: The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh Migr. 6:365–373. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhong X and Rescorla FJ: Cell surface adhesion molecules and adhesion-initiated signaling: Understanding of anoikis resistance mechanisms and therapeutic opportunities. Cell Signal. 24:393–401. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kim YJ, Borsig L, Han HL, Varki NM and Varki A: Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes and endothelium. Am J Pathol. 155:461–472. 1999. View Article : Google Scholar : PubMed/NCBI | |
Ke JJ, Shao QS and Ling ZQ: Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance. World J Gastroenterol. 12:3609–3611. 2006. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Zhao J, Zhang PY, Zhang Y, Sun SY, Yu SY and Xi QS: MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis. Med Sci Monit. 18:BR299–BR308. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Xiang H, Zhang Y, Wang J and Yu G: Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer. Clin Exp Metastasis. 32:417–428. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bevilacqua MP and Nelson RM: Selectins. J Clin Invest. 91:379–387. 1993. View Article : Google Scholar : PubMed/NCBI | |
Benekli M, Güllü IH, Tekuzman G, Savaş MC, Hayran M, Hasçelik G and Firat D: Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer. Br J Cancer. 78:267–271. 1998. View Article : Google Scholar : PubMed/NCBI | |
Borsig L, Wong R, Hynes RO, Varki NM and Varki A: Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci USA. 99:pp. 2193–2198. 2002; View Article : Google Scholar : PubMed/NCBI | |
Makrilia N, Kollias A, Manolopoulos L and Syrigos K: Cell adhesion molecules: Role and clinical significance in cancer. Cancer Invest. 27:1023–1037. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yashiro M, Sunami T and Hirakawa K: CD54 expression is predictive for lymphatic spread in human gastric carcinoma. Dig Dis Sci. 50:2224–2230. 2005. View Article : Google Scholar : PubMed/NCBI | |
Maruo Y, Gochi A, Kaihara A, Shimamura H, Yamada T, Tanaka N and Orita K: ICAM-1 expression and the soluble ICAM-1 level for evaluating the metastatic potential of gastric cancer. Int J Cancer. 100:486–490. 2002. View Article : Google Scholar : PubMed/NCBI | |
Jung WC, Jang YJ, Kim JH, Park SS, Park SH, Kim SJ, Mok YJ and Kim CS: Expression of intercellular adhesion molecule-1 and E-Selectin in gastric cancer and their clinical significance. J Gastric Cancer. 12:140–148. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hsu NY, Chow KC, Chen WJ, Lin CC, Chou FF and Chen CL: Expression of nm23 in the primary tumor and the metastatic regional lymph nodes of patients with gastric cardiac cancer. Clin Cancer Res. 5:1752–1757. 1999.PubMed/NCBI | |
Kim KM, Lee A, Chae HS and Shim SI: Expression of p53 and NDP-K/nm23 in gastric carcinomas-association with metastasis and clinicopathologic parameters. J Korean Med Sci. 10:406–413. 1995. View Article : Google Scholar : PubMed/NCBI | |
Yu G, Wang J, Chen Y, Wang X, Pan J, Li Q and Xie K: Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer. Clin Exp Metastasis. 25:695–702. 2008. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Wang L, Kang A, Fan L, Zhao Q, Tan B, Hao Y and Liu Q: Screening and identification of proteins related to gastric cancer metastasis with comparative proteomics. Nan Fang Yi Ke Da Xue Xue Bao. 35:360–364. 2015.(In Chinese). PubMed/NCBI | |
Li Y, Tan BB, Zhao Q, Fan LQ, Liu Y and Wang D: Regulatory mechanism of ZNF139 in multi-drug resistance of gastric cancer cells. Mol Biol Rep. 41:3603–3610. 2014. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Tan BB, Zhao Q, Fan LQ, Wang D and Liu Y: ZNF139 promotes tumor metastasis by increasing migration and invasion in human gastric cancer cells. Neoplasma. 61:291–298. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ikeda Y, Mori M, Kajiyama K, Haraguchi Y, Sasaki O and Sugimachi K: Immunohistochemical expression of sialyl Tn, sialyl Lewis a, sialyl Lewis a-b- and sialyl Lewis × in primary tumor and metastatic lymph nodes in human gastric cancer. J Surg Oncol. 62:171–176. 1996. View Article : Google Scholar : PubMed/NCBI | |
Pahujaa M, Anikin M and Goldberg GS: Phosphorylation of connexin43 induced by Src: Regulation of gap junctional communication between transformed cells. Exp Cell Res. 313:4083–4090. 2007. View Article : Google Scholar : PubMed/NCBI | |
El-Sabban ME and Pauli BU: Adhesion-mediated gap junctional communication between lung-metastatatic cancer cells and endothelium. Invasion Metastasis. 14:164–176. 1994.PubMed/NCBI | |
Tang B, Peng ZH, Yu PW, Yu G and Qian F: Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes. Med Oncol. 28:502–508. 2011. View Article : Google Scholar : PubMed/NCBI | |
Paliouras GN, Naujokas MA and Park M: Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol Cell Biol. 29:3018–3032. 2009. View Article : Google Scholar : PubMed/NCBI | |
Gherardi E, Birchmeier W, Birchmeier C and Woude GV: Targeting MET in cancer: Rationale and progress. Nat Rev Cancer. 12:89–103. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ma J, Ma J, Meng Q, Zhao ZS and Xu WJ: Prognostic value and clinical pathology of MACC-1 and c-MET expression in gastric carcinoma. Pathol Oncol Res. 19:821–832. 2013. View Article : Google Scholar : PubMed/NCBI | |
Comoglio PM, Giordano S and Trusolino L: Drug development of MET inhibitors: Targeting oncogene addiction and expedience. Nat Rev Drug Discov. 7:504–516. 2008. View Article : Google Scholar : PubMed/NCBI | |
Chan AM, Rubin JS, Bottaro DP, Hirschfield DW, Chedid M and Aaronson SA: Identification of a competitive HGF antagonist encoded by an alternative transcript. Science. 254:1382–1385. 1991. View Article : Google Scholar : PubMed/NCBI | |
Mihailidou C, Karamouzis MV, Schizas D and Papavassiliou AG: Co-targeting c-Met and DNA double-strand breaks (DSBs): Therapeutic strategies in BRCA-mutated gastric carcinomas. Biochimie. 142:135–143. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tian M, Yu L, Zhang Y and Gao X: Correlations between SUVmax and expression of GLUT1 and growth factors inducing lymphangiogenesis. Acad Radiol. 19:420–426. 2012. View Article : Google Scholar : PubMed/NCBI | |
Meng F, Li H, Shi H, Yang Q, Zhang F, Yang Y, Kang L, Zhen T, Dai S, Dong Y and Han A: MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/β-catenin signaling pathway. PLoS One. 8:e608212013. View Article : Google Scholar : PubMed/NCBI | |
Mak H, Naba A, Varma S, Schick C, Day A, SenGupta SK, Arpin M and Elliott BE: Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells. BMC Cancer. 12:822012. View Article : Google Scholar : PubMed/NCBI | |
Wu B, Li J, Huang D, Wang W, Chen Y, Liao Y, Tang X, Xie H and Tang F: Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. BMC Cancer. 11:5272011. View Article : Google Scholar : PubMed/NCBI | |
Li L, Wang YY, Zhao ZS and Ma J: Ezrin is associated with gastric cancer progression and prognosis. Pathol Oncol Res. 17:909–915. 2011. View Article : Google Scholar : PubMed/NCBI | |
Jin J, Jin T, Quan M, Piao Y and Lin Z: Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma. Diagn Pathol. 7:1352012. View Article : Google Scholar : PubMed/NCBI | |
Dong CX, Fu JF, Ye XY, Li XF, Zhong X and Yuan Y: Surgical resection of advanced gastric cancer following trastuzumab/oxaliplatin/capecitabine combination therapy. World J Gastroenterol. 20:12355–12358. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kim K, Chun KH, Suh PG and Kim IH: Alterations in cell proliferation related gene expressions in gastric cancer. Crit Rev Eukaryot Gene Expr. 21:237–254. 2011. View Article : Google Scholar : PubMed/NCBI | |
Birchmeier C, Birchmeier W, Gherardi E and Vande Woude GF: Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 4:915–925. 2003. View Article : Google Scholar : PubMed/NCBI | |
Okines AF, Reynolds AR and Cunningham D: Targeting angiogenesis in esophagogastric adenocarcinoma. Oncologist. 16:844–858. 2011. View Article : Google Scholar : PubMed/NCBI |