miR-106b promotes cell invasion and metastasis via PTEN mediated EMT in ESCC

Zhang,Jianxiang; Chen,Danjie; Liang,Shuying; Wang,Jun; Liu,Can; Nie,Caiping; Shan,Zhengzheng; Wang,Liuxing; Fan,Qinxia; Wang,Feng

doi:10.3892/ol.2018.7861

miR-106b promotes cell invasion and metastasis via PTEN mediated EMT in ESCC

Authors:
- Jianxiang Zhang
- Danjie Chen
- Shuying Liang
- Jun Wang
- Can Liu
- Caiping Nie
- Zhengzheng Shan
- Liuxing Wang
- Qinxia Fan
- Feng Wang
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Affiliations: Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: January 25, 2018 https://doi.org/10.3892/ol.2018.7861
Pages: 4619-4626

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Abstract

MicroRNA (miR)-106b serves an essential function in a variety of human cancer types, particularly in the process of invasion and metastasis. However, the function and mechanism of miR‑106b in the invasion and metastasis of esophageal squamous cell carcinoma (ESCC) has remained elusive. In the present study, it was demonstrated that miR‑106b was upregulated in ESCC tissues and cell lines. Furthermore, miR‑106b expression in ESCC tissues was positively associated with lymphatic metastasis. Inhibition of miR‑106b in EC‑1 and EC9706 cells decreased not only the invasion and metastasis ability but also the proliferation ability of EC‑1 and EC9706 cells. In addition, miR‑106b had the ability to induce epithelial‑to‑mesenchymal transition (EMT) in EC‑1 and EC9706 cells. In terms of the underlying mechanism, it was revealed that miR‑106b promoted the invasion, metastasis and proliferation ability of EC‑1 and EC9706 cells by directly targeting phosphatase and tension homolog (PTEN). Furthermore, miR‑106b induced EMT in EC‑1 and EC9706 cells by suppressing the expression of PTEN. In summary, the present study revealed that miR‑106b contributed to invasion and metastasis in ESCC by regulating PTEN mediated EMT. Downregulation of miR‑106b may be a novel strategy for preventing tumor invasion and metastasis.

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