Novel prognostic scoring system for diffuse large B-cell lymphoma

  • Authors:
    • Pan Zhao
    • Li Zang
    • Xiaoying Zhang
    • Yafang Chen
    • Zhijie Yue
    • Hongliang Yang
    • Haifeng Zhao
    • Yong Yu
    • Yafei Wang
    • Zhigang Zhao
    • Yizhuo Zhang
    • Xiaofang Wang
  • View Affiliations

  • Published online on: February 6, 2018     https://doi.org/10.3892/ol.2018.7966
  • Pages: 5325-5332
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Abstract

The objective of the present study was to evaluate the prognostic values of platelet count (PLT) and platelet to lymphocyte ratio (PLR) in diffuse large B‑cell lymphoma (DLBCL), creating a novel prognostic scoring system. A total of 309 patients with newly diagnosed DLBCL were retrospectively analyzed. Receiver operating characteristic analysis was used to determine the optimal threshold values for PLT and PLR, which were 250x109/l and 170, respectively. The patients with PLT ≥250x109/l and PLR ≥170 experienced significantly decreased overall survival (OS) (P<0.001) and progression‑free survival (PFS) times (P=0.003, P<0.001) In multivariate analysis, PLR was a significant prognostic factor for OS (P<0.001) and PFS (P=0.003) time, whereas PLT was not a risk factor for PFS or OS time. According to the results of Cox regression analysis, a novel prognostic scoring system was created that combined PLR and β2-microglobulin level with International Prognostic Index value or age‑adjusted International Prognostic Index value and the patients were divided into three groups: i) Low‑risk patients with a PLR <170, International Prognostic Index (IPI) <2 scores or age‑adjusted International Prognostic Index (aaIPI)=0 and normal β2m; ii) high‑risk patients with a PLR ≥170, IPI ≥4 or aaIPI=3 and high level of β2m; and iii) intermediate‑risk patients. The novel score predicted 5‑year OS rates of 86.4, 54.1 and 21.1% in the low‑, intermediate‑ and high‑risk groups, respectively (P<0.001). This novel prognostic scoring system may aid the evaluation of patient prognosis and guide treatment.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao P, Zang L, Zhang X, Chen Y, Yue Z, Yang H, Zhao H, Yu Y, Wang Y, Zhao Z, Zhao Z, et al: Novel prognostic scoring system for diffuse large B-cell lymphoma. Oncol Lett 15: 5325-5332, 2018.
APA
Zhao, P., Zang, L., Zhang, X., Chen, Y., Yue, Z., Yang, H. ... Wang, X. (2018). Novel prognostic scoring system for diffuse large B-cell lymphoma. Oncology Letters, 15, 5325-5332. https://doi.org/10.3892/ol.2018.7966
MLA
Zhao, P., Zang, L., Zhang, X., Chen, Y., Yue, Z., Yang, H., Zhao, H., Yu, Y., Wang, Y., Zhao, Z., Zhang, Y., Wang, X."Novel prognostic scoring system for diffuse large B-cell lymphoma". Oncology Letters 15.4 (2018): 5325-5332.
Chicago
Zhao, P., Zang, L., Zhang, X., Chen, Y., Yue, Z., Yang, H., Zhao, H., Yu, Y., Wang, Y., Zhao, Z., Zhang, Y., Wang, X."Novel prognostic scoring system for diffuse large B-cell lymphoma". Oncology Letters 15, no. 4 (2018): 5325-5332. https://doi.org/10.3892/ol.2018.7966