Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy (Review)
- Authors:
- Lijuan Wang
- Yanchun Quan
- Yongfang Yue
- Xueyuan Heng
- Fengyuan Che
-
Affiliations: Central Laboratory, Hematology Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong 276000, P.R. China, Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Neurosurgery, Linyi People's Hospital, Shandong University, Linyi, Shandong 276000, P.R. China - Published online on: February 7, 2018 https://doi.org/10.3892/ol.2018.7982
- Pages: 4711-4719
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|
Moran EM and Mastaglia FL: Cytokines in immune-mediated inflammatory myopathies: Cellular sources, multiple actions and therapeutic implications. Clin Exp Immunol. 178:405–415. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hoeppli RE, Wu D, Cook L and Levings MK: The environment of regulatory T cell biology: Cytokines, metabolites and the microbiome. Front Immunol. 6:612015. View Article : Google Scholar : PubMed/NCBI | |
|
Venkatesha SH, Dudics S, Acharya B and Moudgil KD: Cytokine-modulating strategies and newer cytokine targets for arthritis therapy. Int J Mol Sci. 16:887–906. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Garlanda C, Dinarello CA and Mantovani A: The interleukin-1 family: Back to the future. Immunity. 39:1003–1018. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Dinarello CA: Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 117:3720–3732. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Smith DE: The biological paths of IL-1 family members IL-18 and IL-33. J Leukoc Biol. 89:383–392. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, et al: IL-1 family nomenclature. Nat Immunol. 11:9732010. View Article : Google Scholar : PubMed/NCBI | |
|
Moretti S, Bozza S, Oikonomou V, Renga G, Casagrande A, Iannitti RG, Puccetti M, Garlanda C, Kim S, Li S, et al: IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog. 10:e10044622014. View Article : Google Scholar : PubMed/NCBI | |
|
Boraschi D, Lucchesi D, Hainzl S, Leitner M, Maier E, Mangelberger D, Oostingh GJ, Pfaller T, Pixner C, Posselt G, et al: IL-37: A new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw. 22:127–147. 2011.PubMed/NCBI | |
|
Taylor SL, Renshaw BR, Garka KE, Smith DE and Sims JE: Genomic organization of the interleukin-1 locus. Genomics. 79:726–733. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Ye L and Huang Z: IL-37 restrains autoimmune diseases. Oncotarget. 6:21775–21776. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, An W, Yao Y, Chen R, Zheng X, Yang W, Zhao Y, Hu X, Jiang E, Bie Y, et al: Interleukin 37 expression inhibits STAT3 to Suppress the proliferation and invasion of human cervical cancer cells. J Cancer. 6:962–969. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Wang Z, Yu T, Chen B, Zhang J, Huang K and Huang Z: Increased expression of IL-37 in patients with Graves' disease and its contribution to suppression of proinflammatory cytokines production in peripheral blood mononuclear cells. PLoS One. 9:e1071832014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu W, Deng L, Chen Y, Sun C, Wang J, Zhou L, Li H and Luo R: Anti-inflammatory effect of IL-37b in children with allergic rhinitis. Mediators Inflamm. 2014:7468462014. View Article : Google Scholar : PubMed/NCBI | |
|
Murzin AG, Lesk AM and Chothia C: Beta-Trefoil fold. patterns of structure and sequence in the kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. J Mol Biol. 223:531–543. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Banchereau J, Pascual V and O'Garra A: From IL-2 to IL-37: The expanding spectrum of anti-inflammatory cytokines. Nat Immunol. 13:925–931. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P and Dinarello CA: IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol. 11:1014–1022. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP and Pan Y: Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. Genomics. 66:213–216. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE and Sims JE: Four new members expand the interleukin-1 superfamily. J Biol Chem. 275:1169–1175. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Ross R, Grimmel J, Goedicke S, Möbus AM, Bulau AM, Bufler P, Ali S and Martin MU: Analysis of nuclear localization of interleukin-1 family cytokines by flow cytometry. J Immunol Methods. 387:219–227. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O'Mahony L, Palomares O, et al: Interleukins, from 1 to 37 and interferon-γ: Receptors, functions and roles in diseases. J Allergy Clin Immunol. 127:701–721. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Sonoda H, Shimizu T, Fujiyama Y and Andoh A: Epithelial expression of interleukin-37b in inflammatory bowel disease. Clin Exp Immunol. 172:410–416. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pan G, Risser P, Mao W, Baldwin DT, Zhong AW, Filvaroff E, Yansura D, Lewis L, Eigenbrot C, Henzel WJ and Vandlen R: IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. Cytokine. 13:1–7. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Bufler P, Gamboni-Robertson F, Azam T, Kim SH and Dinarello CA: Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. Biochem J. 381:503–510. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML and Young PR: Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 275:10308–10314. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Dunn E, Sims JE, Nicklin MJ and O'Neill LA: Annotating genes with potential roles in the immune system: Six new members of the IL-1 family. Trends Immunol. 22:533–536. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Bufler P, Azam T, Gamboni-Robertson F, Reznikov LL, Kumar S, Dinarello CA and Kim SH: A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci USA. 99:pp. 13723–13728. 2002; View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Wang Y, Liu Y, Wang Y, Zuo X, Li Y and Lu X: The possible role of the novel cytokines il-35 and il-37 in inflammatory bowel disease. Mediators Inflamm. 2014:1363292014. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma S, Kulk N, Nold MF, Gräf R, Kim SH, Reinhardt D, Dinarello CA and Bufler P: The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol. 180:5477–5482. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
He L, Liang Z, Zhao F, Peng L and Chen Z: Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells. Cell Mol Immunol. 12:515–518. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB, Nold MF, Nold-Petry C, Bufler P, Dinarello CA and Rivera-Nieves J: Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA. 108:pp. 16711–16716. 2011; View Article : Google Scholar : PubMed/NCBI | |
|
Su S, Duan J, Chen T, Huang X, Shang E, Yu L, Wei K, Zhu Y, Guo J, Guo S, et al: Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway. Sci Rep. 5:136682015. View Article : Google Scholar : PubMed/NCBI | |
|
Guo C, Xia Y, Niu P, Jiang L, Duan J, Yu Y, Zhou X, Li Y and Sun Z: Silica nanoparticles induce oxidative stress, inflammation and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling. Int J Nanomedicine. 10:1463–1477. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Fang HU, Zhang HH, Yang BX, Huang JL, Shun JL, Kong FJ, Peng-Xu, Chen ZG and Lu JM: Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia. Brain Res. 1619:166–175. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lei YY, Wang WJ, Mei JH and Wang CL: Mitogen-activated protein kinase signal transduction in solid tumors. Asian Pac J Cancer Prev. 15:8539–8548. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Grossi V, Peserico A, Tezil T and Simone C: p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol. 20:9744–9758. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Jha SK, Jha NK, Kar R, Ambasta RK and Kumar P: p38 MAPK and PI3K/AKT signalling cascades inparkinson's disease. Int J Mol Cell Med. 4:67–86. 2015.PubMed/NCBI | |
|
Lupia E, Pigozzi L, Goffi A, Hirsch E and Montrucchio G: Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis. World J Gastroenterol. 20:15190–15199. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yip PY: Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer. Transl Lung Cancer Res. 4:165–176. 2015.PubMed/NCBI | |
|
Huang Z, Zhao GW, Gao CH, Chi XW, Zeng T, Hu YW, Zheng L and Wang Q: Mannose-capped lipoarabinomannan from mycobacterium tuberculosis induces Il-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells. Int J Clin Exp Med. 8:7279–7287. 2015.PubMed/NCBI | |
|
Rudloff I, Cho SX, Lao JC, Ngo D, McKenzie M, Nold-Petry CA and Nold MF: Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells. J Leukoc Bio. 101:901–911. 2016. View Article : Google Scholar | |
|
Gunaltay S, Ghiboub M, Hultgren O and Hörnquist EH: Reduced IL-37 production increases spontaneous chemokine expressions in colon epithelial cells. Dig Dis Sci. 62:1204–1215. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K and Ogawa H: Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. J Dermatol Sci. 77:46–53. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Zhang ZX, Lian D, Haig A, Bhattacharjee RN and Jevnikar AM: IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury. Kidney Int. 87:396–408. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xie Y, Li Y, Cai X, Wang X and Li J: Interleukin-37 suppresses ICAM-1 expression in parallel with NF-κB down-regulation following TLR2 activation of human coronary artery endothelial cells. Int immunopharmacolo. 38:26–30. 2016. View Article : Google Scholar | |
|
Coll-Miró M, Francos-Quijorna I, Santos-Nogueira E, Torres-Espin A, Bufler P, Dinarello CA and López-Vales R: Beneficial effects of IL-37 after spinal cord injury in mice. Proc Natl Acad Sci USA. 113:pp. 1411–1416. 2016; View Article : Google Scholar : PubMed/NCBI | |
|
Liu M, Guo S, Hibbert JM, Jain V, Singh N, Wilson NO and Stiles JK: CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 22:121–130. 2011.PubMed/NCBI | |
|
Zhao M, Hu Y, Shou J, Su SB, Yang J and Yang T: IL-37 impairs host resistance to listeria infection by suppressing macrophage function. Biochem Biophys Res Commun. 485:563–568. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Neff CP, Barber K, Hong J, Luo Y, Azam T, Palmer BE, Fujita M, Garlanda C, Mantovani A, et al: Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci USA. 112:pp. 2497–2502. 2015; View Article : Google Scholar : PubMed/NCBI | |
|
Zaccone P, Fehervari Z, Blanchard L, Nicoletti F, Edwards CK III and Cooke A: Autoimmune thyroid disease induced by thyroglobulin and lipopolysaccharide is inhibited by soluble TNF receptor type I. Eur J Immunol. 32:1021–1028. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Dujmovic I, Mangano K, Pekmezovic T, Quattrocchi C, Mesaros S, Stojsavljevic N, Nicoletti F and Drulovic J: The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy. J Neuroimmunol. 207:101–106. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Nicoletti F, Patti F, DiMarco R, Zaccone P, Nicoletti A, Meroni P and Reggio A: Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to IFN-beta treatment. Cytokine. 8:395–400. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Nicoletti F, Zaccone P, Di Marco R, Lunetta M, Magro G, Grasso S, Meroni P and Garotta G: Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-gamma antibody. Endocrinology. 138:281–288. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Nicoletti F, Di Marco R, Barcellini W, Magro G, Schorlemmer HU, Kurrle R, Lunetta M, Grasso S, Zaccone P and Meroni P: Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor. Eur J Immunol. 24:1843–1847. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, et al: Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β and TNF-α: Receptors, functions and roles in diseases. J Allergy Clin Immunol. 138:984–1010. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Højen JF, Rasmussen TA, Andersen KL, Winckelmann AA, Laursen RR, Gunst JD, Møller HJ, Fujita M, Østergaard L, Søgaard OS, et al: Interleukin-37 expression is increased in chronic HIV-1-Infected individuals and is associated with inflammation and the size of the total viral reservoir. Mol Med. 21:337–345. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wan ZY, Sun Z, Song F, Chen YF, Zhang WL, Wang HQ and Luo ZJ: Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degeneration. Int J Clin Exp Pathol. 7:656–662. 2014.PubMed/NCBI | |
|
Günaltay S, Nyhlin N, Kumawat AK, Tysk C, Bohr J, Hultgren O and Hultgren Hörnquist E: Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis. World J Gastroenterol. 20:12249–12259. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chen B, Huang K, Ye L, Li Y, Zhang J, Zhang J, Fan X, Liu X, Li L, Sun J, et al: Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity. J Transl Med. 13:362015. View Article : Google Scholar : PubMed/NCBI | |
|
Ye L, Ji L, Wen Z, Zhou Y, Hu D, Li Y, Yu T, Chen B, Zhang J, Ding L, et al: IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: Its correlation with disease activity. J Transl Med. 12:692014. View Article : Google Scholar : PubMed/NCBI | |
|
Ji Q, Zeng Q, Huang Y, Shi Y, Lin Y, Lu Z, Meng K, Wu B, Yu K, Chai M, et al: Elevated plasma IL-37, IL-18 and IL-18BP concentrations in patients with acute coronary syndrome. Mediators Inflamm. 2014:1657422014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Cai X, Chen L, Xu D and Li J: The evaluation of plasma and leukocytic IL-37 expression in early inflammation in patients with acute ST-segment elevation myocardial infarction after PCI. Mediators Inflamm. 2015:6269342015. View Article : Google Scholar : PubMed/NCBI | |
|
Yu K, Min X, Lin Y, Huang Y, Huang S, Liu L, Peng Y, Meng K, Li D, Ji Q and Zeng Q: Increased IL-37 concentrations in patients with arterial calcification. Clin Chim Acta. 461:19–24. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao JJ, Pan QZ, Pan K, Weng DS, Wang QJ, Li JJ, Lv L, Wang DD, Zheng HX and Jiang SS: Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: Role for CD57+ NK cells. Sci Rep. 4:51772014. View Article : Google Scholar : PubMed/NCBI | |
|
Ge G, Wang A, Yang J, Chen Y, Yang J, Li Y and Xue Y: Interleukin-37 suppresses tumor growth through inhibition of angiogenesis in non-small cell lung cancer. J Exp Clin Cancer Res. 35:132016. View Article : Google Scholar : PubMed/NCBI | |
|
Wu BW, Zeng QT, Meng K and Ji QW: The potential role of IL-37 in atherosclerosis. Pharmazie. 68:857–860. 2013.PubMed/NCBI | |
|
Sakai N, Van Sweringen HL, Belizaire RM, Quillin RC, Schuster R, Blanchard J, Burns JM, Tevar AD, Edwards MJ and Lentsch AB: Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol. 27:1609–1616. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Luo Y, Cai X, Liu S, Wang S, Nold-Petry CA, Nold MF, Bufler P, Norris D, Dinarello CA and Fujita M: Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci USA. 111:pp. 15178–15183. 2014; View Article : Google Scholar : PubMed/NCBI | |
|
Jethwa H and Bowness P: The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: New advances and potentials for treatment. Clin Exp Immunol. 138:30–36. 2016. View Article : Google Scholar | |
|
Ballak DB, van Diepen JA, Moschen AR, Jansen HJ, Hijmans A, Groenhof GJ, Leenders F, Bufler P, Boekschoten MV, Müller M, et al: IL-37 protects against obesity-induced inflammation and insulin resistance. Nat Commun. 5:47112014. View Article : Google Scholar : PubMed/NCBI | |
|
Burdo TH, Lentz MR, Autissier P, Krishnan A, Halpern E, Letendre S, Rosenberg ES, Ellis RJ and Williams KC: Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J Infect Dis. 204:154–163. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE, Pedersen C, Ruxrungtham K, Lewin SR, Emery S, et al: Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis. 203:780–790. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wu GC, Li HM, Wang JB, Leng RX, Wang DG and Ye DQ: Elevated plasma interleukin-37 levels in systemic lupus erythematosus patients. Lupus. 25:1377–1380. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Song L, Qiu F, Fan Y, Ding F, Liu H, Shu Q, Liu W and Li X: Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus. J Clin Immunol. 33:111–117. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Yang T, Fang F, Chen Y, Ma J, Xiao Z, Zou S, Zheng N, Yan D, Liao S, Chen S, et al: Elevated plasma interleukin-37 playing an important role in acute coronary syndrome through suppression of ROCK activation. Oncotarget. 8:9686–9695. 2017.PubMed/NCBI | |
|
Liu K, Tang Q, Zhu X and Yang X: IL-37 increased in patients with acute coronary syndrome and associated with a worse clinical outcome after ST-segment elevation acute myocardial infarction. Clin Chim Acta. 468:140–144. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xu D, Wang A, Jiang F, Hu J and Zhang X: Effects of interleukin-37 on cardiac function after myocardial infarction in mice. Int J Clin Exp Pathol. 8:5247–5251. 2015.PubMed/NCBI | |
|
Zhang XQ, Tang R, Li L, Szucsik A, Javan H, Saegusa N, Spitzer KW and Selzman CH: Cardiomyocyte-specific p65 NF-kappaB deletion protects the injured heart by preservation of calcium handling. Am J Physiol Heart Circ Physiol. 305:H1089–H1097. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng M, Wei X, Wu Z, Li W, Li B, Zhen Y, Chen J, Wang P and Fei Y: NF-κB-mediated induction of autophagy in cardiac ischemia/reperfusion injury. Biochem Biophys Res Commun. 436:180–185. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA and Meng X: Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine. 95:55–63. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ding VA, Zhu Z, Xiao H, Wakefield MR, Bai Q and Fang Y: The role of IL-37 in cancer. Med Oncol. 33:682016. View Article : Google Scholar : PubMed/NCBI | |
|
Abulkhir A, Samarani S, Amre D, Duval M, Haddad E, Sinnett D, Leclerc JM, Diorio C and Ahmad A: A protective role of IL-37 in cancer: A new hope for cancer patients. J Leukoc Biol. 101:395–406. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Moretta L, Pietra G, Montaldo E, Vacca P, Pende D, Falco M, Del Zotto G, Locatelli F, Moretta A and Mingari MC: Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. Front Immunol. 5:872014. View Article : Google Scholar : PubMed/NCBI | |
|
Kunz M and Ibrahim SM: Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm. 2009:9792582009. View Article : Google Scholar : PubMed/NCBI | |
|
Semerano L, Assier E and Boissier MC: Anti-cytokine vaccination: A new biotherapy of autoimmunity? Autoimmun Rev. 11:785–786. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Taylor PC and Williams RO: Combination cytokine blockade: The way forward in therapy for rheumatoid arthritis? Arthritis Rheumatol. 67:14–16. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Striz I, Brabcova E, Kolesar L and Sekerkova A: Cytokine networking of innate immunity cells: A potential target of therapy. Clin Sci (Lond). 126:593–612. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Gao W, Kumar S, Lotze MT, Hanning C, Robbins PD and Gambotto A: Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol. 170:107–113. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Yin D, Naji DH, Xia Y, Li S, Bai Y, Jiang G, Zhao Y, Wang X, Huang Y, Chen S, et al: Genomic Variant in IL-37 confers a significant risk of coronary artery disease. Scientific reports. 7:421752017. View Article : Google Scholar : PubMed/NCBI |
