1
|
Kitahara CM and Sosa JA: The changing
incidence of thyroid cancer. Nat Rev Endocrinol. 12:646–653. 2016.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Ferlay J, Soerjomataram I, Ervik M,
Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and
Bray F: GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality
Worldwide: IARC CancerBase No. 11 (Internet). International Agency
for Research on Cancer; Lyon: 2013, http://globocan.iarc.fr/Default.aspx
|
3
|
DeLellis RA and Williams ED: Tumours of
the thyroid and parathyroidWHO Classification of Tumours: Pathology
and Genetics of Tumours of Endocrine Organs. DeLellis RA, Lloyd RV,
Heitz PU and Eng C: IARC Press; Lyon: pp. 51–56. 2004
|
4
|
Marcello MA, Malandrino P, Almeida JF,
Martins MB, Cunha LL, Bufalo NE, Pellegriti G and Ward LS: The
influence of the environment on the development of thyroid tumors:
A new appraisal. Endocr Relat Cancer. 21:T235–T254. 2014.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Landa I and Robledo M: Association studies
in thyroid cancer susceptibility: Are we on the right track? J Mol
Endocrinol. 47:R43–R58. 2011. View Article : Google Scholar
|
6
|
Gudmundsson J, Sulem P, Gudbjartsson DF,
Jonasson JG, Masson G, He H, Jonasdottir A, Sigurdsson A, Stacey
SN, Johannsdottir H, et al: Discovery of common variants associated
with low TSH levels and thyroid cancer risk. Nat Genet. 44:319–322.
2012. View Article : Google Scholar : PubMed/NCBI
|
7
|
Gudmundsson J, Sulem P, Gudbjartsson DF,
Jonasson JG, Sigurdsson A, Bergthorsson JT, He H, Blondal T, Geller
F, Jakobsdottir M, et al: Common variants on 9q22.33 and 14q13.3
predispose to thyroid cancer in European populations. Nat Genet.
41:460–464. 2009. View
Article : Google Scholar : PubMed/NCBI
|
8
|
Gudmundsson J, Thorleifsson G, Sigurdsson
JK, Stefansdottir L, Jonasson JG, Gudjonsson SA, Gudbjartsson DF,
Masson G, Johannsdottir H, Halldorsson GH, et al: A genome-wide
association study yields five novel thyroid cancer risk loci. Nat
Commun. 8:145172017. View Article : Google Scholar : PubMed/NCBI
|
9
|
Takahashi M, Saenko VA, Rogounovitch TI,
Kawaguchi T, Drozd VM, Takigawa-Imamura H, Akulevich NM,
Ratanajaraya C, Mitsutake N, Takamura N, et al: The FOXE1 locus is
a major genetic determinant for radiation-related thyroid carcinoma
in Chernobyl. Hum Mol Genet. 19:2516–2523. 2010. View Article : Google Scholar : PubMed/NCBI
|
10
|
Köhler A, Chen B, Gemignani F, Elisei R,
Romei C, Figlioli G, Cipollini M, Cristaudo A, Bambi F, Hoffmann P,
et al: Genome-Wide Association Study on Differentiated Thyroid
Cancer. J Clin Endocrinol Metab. 98:E1674–E1681. 2013. View Article : Google Scholar : PubMed/NCBI
|
11
|
Mancikova V, Cruz R, Inglada-Pérez L,
Fernández-Rozadilla C, Landa I, Cameselle-Teijeiro J, Celeiro C,
Pastor S, Velázquez A, Marcos R, et al: Thyroid cancer GWAS
identifies 10q26.12 and 6q14.1 as novel susceptibility loci and
reveals genetic heterogeneity among populations. Int J Cancer.
137:1870–1878. 2015. View Article : Google Scholar : PubMed/NCBI
|
12
|
Son HY, Hwangbo Y, Yoo SK, Im SW, Yang SD,
Kwak SJ, Park MS, Kwak SH, Cho SW, Ryu JS, et al: Genome-wide
association and expression quantitative trait loci studies identify
multiple susceptibility loci for thyroid cancer. Nat Commun.
8:159662017. View Article : Google Scholar : PubMed/NCBI
|
13
|
Figlioli G, Köhler A, Chen B, Elisei R,
Romei C, Cipollini M, Cristaudo A, Bambi F, Paolicchi E, Hoffmann
P, et al: Novel genome-wide association study-based candidate loci
for differentiated thyroid cancer risk. J Clin Endocrinol Metab.
99:E2084–E2092. 2014. View Article : Google Scholar : PubMed/NCBI
|
14
|
Figlioli G, Elisei R, Romei C, Melaiu O,
Cipollini M, Bambi F, Chen B, Köhler A, Cristaudo A, Hemminki K, et
al: A comprehensive meta-analysis of case-control association
studies to evaluate polymorphisms associated with the risk of
differentiated thyroid carcinoma. Cancer Epidemiol Biomarkers Prev.
25:700–713. 2016. View Article : Google Scholar : PubMed/NCBI
|
15
|
Figlioli G, Chen B, Elisei R, Romei C,
Campo C, Cipollini M, Cristaudo A, Bambi F, Paolicchi E, Hoffmann
P, et al: Novel genetic variants in differentiated thyroid cancer
and assessment of the cumulative risk. 5:89222015.
|
16
|
Landa I, Boullosa C, Inglada-Pérez L,
Sastre-Perona A, Pastor S, Velázquez A, Mancikova V, Ruiz-Llorente
S, Schiavi F, Marcos R, et al: An Epistatic Interaction between the
PAX8 and STK17B genes in papillary thyroid cancer susceptibility.
PLoS One. 8:e747652013. View Article : Google Scholar : PubMed/NCBI
|
17
|
Adjadj E, Schlumberger M and de Vathaire
F: Germ-line DNA polymorphisms and susceptibility to differentiated
thyroid cancer. Lancet Oncol. 10:181–190. 2009. View Article : Google Scholar : PubMed/NCBI
|
18
|
Ho T, Li G, Lu J, Zhao C, Wei Q and
Sturgis EM: Association of XRCC1 polymorphisms and risk of
differentiated thyroid carcinoma: A case-control analysis. Thyroid.
19:129–135. 2009. View Article : Google Scholar : PubMed/NCBI
|
19
|
Santos LS, Branco SC, Silva SN, Azevedo
AP, Gil OM, Manita I, Ferreira TC, Limbert E, Rueff J and Gaspar
JF: Polymorphisms in base excision repair genes and thyroid cancer
risk. Oncol Rep. 28:1859–1868. 2012. View Article : Google Scholar : PubMed/NCBI
|
20
|
Silva SN, Gil OM, Oliveira VC, Cabral MN,
Azevedo AP, Faber A, Manita I, Ferreira TC, Limbert E, Pina JE, et
al: Association of polymorphisms in ERCC2 gene with non-familial
thyroid cancer risk. Cancer Epidemiol Biomarkers Prev.
14:2407–2412. 2005. View Article : Google Scholar : PubMed/NCBI
|
21
|
Santos LS, Gomes BC, Gouveia R, Silva SN,
Azevedo AP, Camacho V, Manita I, Gil OM, Ferreira TC, Limbert E, et
al: The role of CCNH Val270Ala (rs2230641) and other nucleotide
excision repair polymorphisms in individual susceptibility to
well-differentiated thyroid cancer. Oncol Rep. 30:2458–2466. 2013.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Gomes BC, Silva SN, Azevedo AP, Manita I,
Gil OM, Ferreira TC, Limbert E, Rueff J and Gaspar JF: The role of
common variants of non-homologous end-joining repair genes XRCC4,
LIG4 and Ku80 in thyroid cancer risk. Oncol Rep. 24:1079–1085.
2010.PubMed/NCBI
|
23
|
Rahimi M, Fayaz S, Fard-Esfahani A,
Modarressi MH, Akrami SM and Fard-Esfahani P: The role of
Ile3434Thr XRCC7 gene polymorphism in differentiated thyroid cancer
risk in an Iranian population. Iran Biomed J. 16:218–222.
2012.PubMed/NCBI
|
24
|
Xu L, Doan PC, Wei Q, Liu Y, Li G and
Sturgis EM: Association of BRCA1 functional single nucleotide
polymorphisms with risk of differentiated thyroid carcinoma.
Thyroid. 22:35–43. 2012. View Article : Google Scholar : PubMed/NCBI
|
25
|
Siraj AK, Al-Rasheed M, Ibrahim M,
Siddiqui K, Al-Dayel F, Al-Sanea O, Uddin S and Al-Kuraya K: RAD52
polymorphisms contribute to the development of papillary thyroid
cancer susceptibility in middle eastern population. J Endocrinol
Invest. 31:893–899. 2008. View Article : Google Scholar : PubMed/NCBI
|
26
|
Bastos HN, Antão MR, Silva SN, Azevedo AP,
Manita I, Teixeira V, Pina JE, Gil OM, Ferreira TC, Limbert E, et
al: Association of polymorphisms in genes of the homologous
recombination DNA repair pathway and thyroid cancer risk. Thyroid.
19:1067–1075. 2009. View Article : Google Scholar : PubMed/NCBI
|
27
|
Hsieh P and Yamane K: DNA mismatch repair:
Molecular mechanism, cancer and ageing. Mech Ageing Dev.
129:391–407. 2008. View Article : Google Scholar : PubMed/NCBI
|
28
|
Edelbrock MA, Kaliyaperumal S and Williams
KJ: Structural, molecular and cellular functions of MSH2 and MSH6
during DNA mismatch repair, damage signaling and other noncanonical
activities. Mutat Res 743–744. 1–66. 2013.
|
29
|
Bridge G, Rashid S and Martin S: DNA
Mismatch repair and oxidative DNA damage: Implications for cancer
biology and treatment. Cancers (Basel). 6:1597–1614. 2014.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Li Z, Pearlman AH and Hsieh P: DNA
mismatch repair and the DNA damage response. DNA Repair(Amst).
38:94–101. 2016. View Article : Google Scholar : PubMed/NCBI
|
31
|
Peltomäki P: Update on Lynch syndrome
genomics. Fam Cancer. 15:385–393. 2016. View Article : Google Scholar : PubMed/NCBI
|
32
|
Thompson BA, Spurdle AB, Plazzer JP,
Greenblatt MS, Akagi K, Al-Mulla F, Bapat B, Bernstein I, Capellá
G, den Dunnen JT, et al: Application of a 5-tiered scheme for
standardized classification of 2,360 unique mismatch repair gene
variants in the InSiGHT locus-specific database. Nat Genet.
46:107–115. 2014. View Article : Google Scholar : PubMed/NCBI
|
33
|
Kunstman JW, Juhlin CC, Goh G, Brown TC,
Stenman A, Healy JM, Rubinstein JC, Choi M, Kiss N, Nelson-Williams
C, et al: Characterization of the mutational landscape of
anaplastic thyroid cancer via whole-exome sequencing. Hum Mol
Genet. 24:2318–2329. 2015. View Article : Google Scholar : PubMed/NCBI
|
34
|
Yu Y, Dong L, Li D, Chuai S, Wu Z, Zheng
X, Cheng Y, Han L, Yu J and Gao M: Targeted DNA sequencing detects
mutations related to susceptibility among familial non-medullary
thyroid cancer. Sci Rep. 5:161292015. View Article : Google Scholar : PubMed/NCBI
|
35
|
Xu B and Ghossein R: Genomic landscape of
poorly differentiated and anaplastic thyroid carcinoma. Endocr
Pathol. 27:205–212. 2016. View Article : Google Scholar : PubMed/NCBI
|
36
|
Broaddus RR, Lynch PM, Lu KH, Luthra R and
Michelson SJ: Unusual tumors associated with the hereditary
nonpolyposis colorectal cancer syndrome. Mod Pathol. 17:981–989.
2004. View Article : Google Scholar : PubMed/NCBI
|
37
|
Johnson JM, Chen J, Ali SM, Dardi IK,
Tuluc M, Cognetti D, Campling B and Sama AR: Molecular profiling of
synchronous colon cancers and anaplastic thyroid cancer in a
patient with lynch syndrome. J Gastrointest Cancer. Oct
6–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
|
38
|
Pande M, Wei C, Chen J, Amos CI, Lynch PM,
Lu KH, Lucio LA, Boyd-Rogers SG, Bannon SA, Mork ME and Frazier ML:
Cancer spectrum in DNA mismatch repair gene mutation carriers:
Results from a hospital based Lynch syndrome registry. Fam Cancer.
11:441–447. 2012. View Article : Google Scholar : PubMed/NCBI
|
39
|
Stulp RP, Herkert JC, Karrenbeld A, Mol B,
Vos YJ and Sijmons RH: Thyroid cancer in a patient with a germline
MSH2 mutation. Case report and review of the Lynch syndrome
expanding tumour spectrum. Hered Cancer Clin Pract. 6:15–21. 2008.
View Article : Google Scholar : PubMed/NCBI
|
40
|
Pelizzo MR, Pennelli G, Zane M, Galuppini
F, Colletti PM, Merante Boschin I and Rubello D: Papillary thyroid
carcinoma (PTC) in Lynch syndrome: Report of two cases and
discussion on Lynch syndrome behaviour and genetics. Biomed
Pharmacother. 74:9–16. 2015. View Article : Google Scholar : PubMed/NCBI
|
41
|
Gatzidou E, Michailidi C,
Tseleni-Balafouta S and Theocharis S: An epitome of DNA repair
related genes and mechanisms in thyroid carcinoma. Cancer Lett.
290:139–147. 2010. View Article : Google Scholar : PubMed/NCBI
|
42
|
Solé X, Guinó E, Valls J, Iniesta R and
Moreno V: SNPStats: A web tool for the analysis of association
studies. Bioinformatics. 22:1928–1929. 2006. View Article : Google Scholar : PubMed/NCBI
|
43
|
Machiela MJ and Chanock SJ: LDlink: A
web-based application for exploring population-specific haplotype
structure and linking correlated alleles of possible functional
variants. Bioinformatics. 31:3555–3557. 2015. View Article : Google Scholar : PubMed/NCBI
|
44
|
Han W, Kim KY, Yang SJ, Noh DY, Kang D and
Kwack K: SNP-SNP interactions between DNA repair genes were
associated with breast cancer risk in a Korean population. Cancer.
118:594–602. 2012. View Article : Google Scholar : PubMed/NCBI
|
45
|
Sapkota Y, Mackey JR, Lai R,
Franco-Villalobos C, Lupichuk S, Robson PJ, Kopciuk K, Cass CE,
Yasui Y and Damaraju S: Assessing SNP-SNP interactions among DNA
Repair, modification and metabolism related pathway genes in breast
cancer susceptibility. PLoS One. 8:e648962013. View Article : Google Scholar : PubMed/NCBI
|
46
|
Berndt SI, Platz EA, Fallin MD, Thuita LW,
Hoffman SC and Helzlsouer KJ: Mismatch repair polymorphisms and the
risk of colorectal cancer. Int J Cancer. 120:1548–1554. 2007.
View Article : Google Scholar : PubMed/NCBI
|
47
|
Campbell PT, Curtin K, Ulrich CM, Samowitz
WS, Bigler J, Velicer CM, Caan B, Potter JD and Slattery ML:
Mismatch repair polymorphisms and risk of colon cancer, tumour
microsatellite instability and interactions with lifestyle factors.
Gut. 58:661–667. 2009. View Article : Google Scholar : PubMed/NCBI
|
48
|
Lee E, Levine EA, Franco VI, Allen GO,
Gong F, Zhang Y and Hu JJ: Combined genetic and nutritional risk
models of triple negative breast cancer. Nutr Cancer. 66:955–963.
2014. View Article : Google Scholar : PubMed/NCBI
|
49
|
Sanyal S, De Verdier PJ, Steineck G,
Larsson P, Onelöv E, Hemminki K and Kumar R: Polymorphisms in XPD,
XPC and the risk of death in patients with urinary bladder
neoplasms. Acta Oncol. 46:31–41. 2007. View Article : Google Scholar : PubMed/NCBI
|
50
|
Liu Y, Zhang X, Jia J, Tang L, Gao X, Yan
L, Wang L, Yu F, Ma N, Liu W, et al: Correlation between
polymorphisms in DNA mismatch repair genes and the risk of primary
hepatocellular carcinoma for the Han population in northern China.
Scand J Gastroenterol. 50:1404–1410. 2015. View Article : Google Scholar : PubMed/NCBI
|
51
|
Tulupova E, Kumar R, Hanova M, Slyskova J,
Pardini B, Polakova V, Naccarati A, Vodickova L, Novotny J,
Halamkova J, et al: Do polymorphisms and haplotypes of mismatch
repair genes modulate risk of sporadic colorectal cancer? Mutat
Res. 648:1–45. 2008. View Article : Google Scholar : PubMed/NCBI
|
52
|
Dong X, Li Y, Chang P, Hess KR, Abbruzzese
JL and Li D: DNA mismatch repair network gene polymorphism as a
susceptibility factor for pancreatic cancer. Mol Carcinog.
51:491–499. 2012. View Article : Google Scholar : PubMed/NCBI
|
53
|
Conde J, Silva SN, Azevedo AP, Teixeira V,
Pina JE, Rueff J and Gaspar JF: Association of common variants in
mismatch repair genes and breast cancer susceptibility: A multigene
study. BMC Cancer. 9:3442009. View Article : Google Scholar : PubMed/NCBI
|
54
|
Curtin K, Samowitz WS, Wolff RK, Caan BJ,
Ulrich CM, Potter JD and Slattery ML: MSH6 G39E polymorphism and
CpG island methylator phenotype in colon cancer. Mol Carcinog.
48:989–994. 2009. View Article : Google Scholar : PubMed/NCBI
|
55
|
Landi S, Gemignani F, Canzian F, Gaborieau
V, Barale R, Landi D, Szeszenia-Dabrowska N, Zaridze D, Lissowska
J, Rudnai P, et al: DNA repair and cell cycle control genes and the
risk of young-onset lung cancer. Cancer Res. 66:11062–11069. 2006.
View Article : Google Scholar : PubMed/NCBI
|
56
|
Picelli S, Zajac P, Zhou XL, Edler D,
Lenander C, Dalén J, Hjern F, Lundqvist N, Lindforss U, Påhlman L,
et al: Common variants in human CRC genes as low-risk alleles. Eur
J Cancer. 46:1041–1048. 2010. View Article : Google Scholar : PubMed/NCBI
|
57
|
Smith TR, Levine EA, Freimanis RI, Akman
SA, Allen GO, Hoang KN, Liu-Mares W and Hu JJ: Polygenic model of
DNA repair genetic polymorphisms in human breast cancer risk.
Carcinogenesis. 29:2132–2138. 2008. View Article : Google Scholar : PubMed/NCBI
|
58
|
Li Z, Kong L, Yu L, Huang J, Wang K, Chen
S, Yu M and Wei S: Association between MSH6 G39E polymorphism and
cancer susceptibility: A meta-analysis of 7,046 cases and 34,554
controls. Tumour Biol. 35:6029–6037. 2014. View Article : Google Scholar : PubMed/NCBI
|
59
|
Chang YC, Chang JG, Liu TC, Lin CY, Yang
SF, Ho CM, Chen WT and Chang YS: Mutation analysis of 13 driver
genes of colorectal cancer-related pathways in Taiwanese patients.
World J Gastroenterol. 22:2314–2325. 2016. View Article : Google Scholar : PubMed/NCBI
|
60
|
Kukita Y, Okami J, Yoneda-Kato N, Nakamae
I, Kawabata T, Higashiyama M, Kato J, Kodama K and Kato K:
Homozygous inactivation of CHEK2 is linked to a familial case of
multiple primary lung cancer with accompanying cancers in other
organs. Cold Spring Harb Mol Case Stud. 2:a0010322016. View Article : Google Scholar : PubMed/NCBI
|
61
|
Talseth-Palmer BA, Bauer DC, Sjursen W,
Evans TJ, McPhillips M, Proietto A, Otton G, Spigelman AD and Scott
RJ: Targeted next-generation sequencing of 22 mismatch repair genes
identifies Lynch syndrome families. Cancer Med. 5:929–941. 2016.
View Article : Google Scholar : PubMed/NCBI
|
62
|
Lynch HT and Shaw TG: Practical genetics
of colorectal cancer. Chin Clin Oncol. 2:122013.PubMed/NCBI
|
63
|
Warren JJ, Pohlhaus TJ, Changela A, Iyer
RR, Modrich PL and Beese Lorena S: Structure of the Human MutSalpha
DNA lesion recognition complex. Mol Cell. 26:579–592. 2007.
View Article : Google Scholar : PubMed/NCBI
|
64
|
Clark AB, Deterding L, Tomer KB and Kunkel
TA: Multiple functions for the N-terminal region of Msh6. Nucleic
Acids Res. 35:4114–4123. 2007. View Article : Google Scholar : PubMed/NCBI
|
65
|
Derwahl M and Nicula D: Estrogen and its
role in thyroid cancer. Endocr Relat Cancer. 21:T273–T283. 2014.
View Article : Google Scholar : PubMed/NCBI
|
66
|
Nielsen SM, White MG, Hong S,
Aschebrook-Kilfoy B, Kaplan EL, Angelos P, Kulkarni SA, Olopade OI
and Grogan RH: The breast-thyroid cancer link: A systematic review
and meta-analysis. Cancer Epidemiol Biomarkers Prev. 25:231–238.
2016. View Article : Google Scholar : PubMed/NCBI
|
67
|
Chuffa LG, Lupi-Júnior LA, Costa AB,
Amorim JP and Seiva FR: The role of sex hormones and steroid
receptors on female reproductive cancers. Steroids. 118:93–108.
2017. View Article : Google Scholar : PubMed/NCBI
|
68
|
Cavalieri E and Rogan E: The molecular
etiology and prevention of estrogen-initiated cancers: Ockham's
Razor: Pluralitas non est ponenda sine necessitate. Plurality
should not be posited without necessity. Mol Aspects Med. 36:1–55.
2014. View Article : Google Scholar : PubMed/NCBI
|
69
|
Yager JD: Mechanisms of estrogen
carcinogenesis: The role of E2/E1-quinone metabolites suggests new
approaches to preventive intervention-A review. Steroids. 99:56–60.
2015. View Article : Google Scholar : PubMed/NCBI
|
70
|
Vahteristo P, Ojala S, Tamminen A,
Tommiska J, Sammalkorpi H, Kiuru-Kuhlefelt S, Eerola H, Aaltonen
LA, Aittomäki K and Nevanlinna H: No MSH6 germline mutations in
breast cancer families with colorectal and/or endometrial cancer. J
Med Genet. 42:e222005. View Article : Google Scholar : PubMed/NCBI
|
71
|
Wada-Hiraike O, Yano T, Nei T, Matsumoto
Y, Nagasaka K, Takizawa S, Oishi H, Arimoto T, Nakagawa S, Yasugi
T, et al: The DNA mismatch repair gene hMSH2 is a potent
coactivator of oestrogen receptor alpha. Br J Cancer. 92:2286–2291.
2005. View Article : Google Scholar : PubMed/NCBI
|
72
|
Nemec AA, Bush KB, Towle-Weicksel JB,
Taylor BF, Schulz V, Weidhaas JB, Tuck DP and Sweasy JB: Estrogen
drives cellular transformation and mutagenesis in cells expressing
the breast cancer-associated R438W DNA polymerase lambda protein.
Mol Cancer Res. 14:1068–1077. 2016. View Article : Google Scholar : PubMed/NCBI
|
73
|
Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY
and Yu JC: Breast cancer risk is associated with the genes encoding
the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Cancer
Epidemiol Biomarkers Prev. 16:2024–2032. 2007. View Article : Google Scholar : PubMed/NCBI
|
74
|
Ming-Shiean H, Yu JC, Wang HW, Chen ST,
Hsiung CN, Ding SL, Wu PE, Shen CY and Cheng CW: Synergistic
effects of polymorphisms in DNA repair genes and endogenous
estrogen exposure on female breast cancer risk. Ann Surg Oncol.
17:760–771. 2010. View Article : Google Scholar : PubMed/NCBI
|
75
|
Chang IY, Jin M, Yoon SP, Youn CK, Yoon Y,
Moon SP, Hyun JW, Jun JY and You HJ: Senescence-dependent MutS
alpha dysfunction attenuates mismatch repair. Mol Cancer Res.
6:978–989. 2008. View Article : Google Scholar : PubMed/NCBI
|