Potential tumor suppressing role of microRNA-545 in epithelial ovarian cancer

Jia,Xibiao; Liu,Xiaogang; Li,Ming; Zeng,Yu; Feng,Zaoming; Su,Xian; Huang,Yan; Chen,Maomao; Yang,Xueyi

doi:10.3892/ol.2018.8130

Potential tumor suppressing role of microRNA-545 in epithelial ovarian cancer

Authors:
- Xibiao Jia
- Xiaogang Liu
- Ming Li
- Yu Zeng
- Zaoming Feng
- Xian Su
- Yan Huang
- Maomao Chen
- Xueyi Yang
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Affiliations: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Obstetrics and Gynaecology, People's Hospital of Yuxi, Yuxi, Yunnan 653100, P.R. China, Centre for Disease Prevention and Control, Chengdu Military Region, Chengdu, Sichuan 610021, P.R. China, Department of Gastroenterology, The People's Liberation Army 452 Hospital, Chengdu, Sichuan 610021, P.R. China, Department of Internal Medicine, The Third People's Hospital, Chengdu, Sichuan 610021, P.R. China, Department of Neurology, The Third People's Hospital, Chengdu, Sichuan 610031, P.R. China, Department of Inspection and Pharmacy, Jiangsu College of Nursing, Huaian, Jiangsu 223001, P.R. China
Published online on: February 27, 2018 https://doi.org/10.3892/ol.2018.8130
Pages: 6386-6392
Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer, which exhibits invasive traits. MicroRNAs (miRNAs/miRs) have been demonstrated to serve important functions in the pathogenesis of EOC. However, the function of miR‑545 in EOC remains unknown. In the present study, the function of miR‑545 in EOC was analyzed and it was identified that miR-545 is downregulated in EOC tissues and cell lines. Additionally, a low level of miR‑545 expression was associated with a low survival rate of patients with EOC. Furthermore, overexpression of miR‑545 inhibited cell growth and promoted apoptosis. Suppression of miR‑545 promoted cell growth and inhibited apoptosis. Additionally, the RAC‑γ serine/threonine‑protein kinase gene was targeted by miR‑545. Thus, it may be concluded that miR‑545 exhibited antitumor traits in EOC.

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