Three-dimensional proton magnetic resonance spectroscopy and diffusion-weighted imaging in the differentiation of incidental prostate carcinoma from benign prostate hyperplasia

Zhang,Xue‑Qin; Yu,Xiang‑Rong; Du,Zhong‑Li; Miao,Xiao‑Fen; Lu,Jian; Zhou,Quan

doi:10.3892/ol.2018.8131

Three-dimensional proton magnetic resonance spectroscopy and diffusion-weighted imaging in the differentiation of incidental prostate carcinoma from benign prostate hyperplasia

Authors:
- Xue‑Qin Zhang
- Xiang‑Rong Yu
- Zhong‑Li Du
- Xiao‑Fen Miao
- Jian Lu
- Quan Zhou
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Affiliations: Department of Radiology, The Third People's Hospital of Nantong, Nantong, Jiangsu 226006, P.R. China, Department of Radiology, Zhuhai Hospital of Jinan University, Zhuhai People's Hospital, Zhuhai, Guangdong 519000, P.R. China, Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510000, P.R. China
Published online on: February 27, 2018 https://doi.org/10.3892/ol.2018.8131
Pages: 6541-6546

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Abstract

The present study evaluated three-dimensional proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) features in differentiating incidental prostate carcinoma (IPCa) and benign prostate hyperplasia (BPH) in the central gland of the prostate. The clinical and imaging data of 9 patients with IPCa, 118 patients with BPH [including those with glandular hyperplasia (GH), stromal hyperplasia (SH) and mixed hyperplasia (MH)], were retrospectively analyzed. The mean (choline + creatine)/citrate (CC/C) value of 3D MRS, the apparent diffusion coefficient (ADC) value and the minimal ADC value of DWI were compared between carcinoma and non‑carcinoma tissues. The mean CC/C values were 1.04±0.28, and 1.09±0.58 in IPCa and BPH, respectively (t=‑0.205, P=0.838). No significant difference in CC/C values (χ2=2.595, P=0.458) could be detected between IPCa, GH, SH and MH groups. The ADC values of the central gland only differed between IPCa (1.48±0.18) x10‑3 and GH (1.60±0.16) x10‑3 mm2/sec (P=0.037). The minimal ADC values were similar between IPCa (1.15±0.10) x10‑3 and BPH (1.14±0.11) x10‑3 mm2/sec, no significant differences could be detected between IPCa and GH (P=0.930), IPCa and SH (P=0.192), and IPCa and MH (P=0.544). Although the ADC values of the central gland of the prostate differed between IPCa and GH, the findings of the present study therefore indicate that combining 3D MRS with DWI cannot potentially improve the detection of IPCa.

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