Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia

  • Authors:
    • Adrian Krygier
    • Dagmara Szmajda
    • Marta Żebrowska
    • Agnieszka Jeleń
    • Ewa Balcerczak
  • View Affiliations

  • Published online on: March 1, 2018     https://doi.org/10.3892/ol.2018.8143
  • Pages: 6733-6738
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Abstract

The aim of the present study was to evaluate the mRNA expression level of the runt‑related transcription factor 1 (RUNX1) and runt‑related transcription factor 3 (RUNX3) genes in patients with acute myeloid leukemia (AML). The etiology of AML is not yet fully known, but certain genetic factors may contribute to its manifestation. The RUNX1 and RUNX3 genes have been demonstrated to serve a role in the transcription process. The group investigated in the present study included 43 patients diagnosed with AML, and the relative RUNX1 and RUNX3 expression levels were determined using reverse transcription‑quantitative polymerase chain reaction. The results indicated that RUNX1 and RUNX3 expression was associated with clinicopathological features, including sex and mortality risk. Expression levels of the RUNX1 gene were higher and more variable among females (P=0.044), and mortality was more frequent among patients with a higher RUNX3 expression level (P=0.036). The data obtained from the present study suggested that RUNX3 expression may have potential value as a prognostic factor; furthermore, sex is potentially a factor that may affect the difference in RUNX1 gene expression level among females and males. Further analyses in this field will aid in the identification and elucidation of the molecular basis of leukemia.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Krygier A, Szmajda D, Żebrowska M, Jeleń A and Balcerczak E: Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia. Oncol Lett 15: 6733-6738, 2018.
APA
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., & Balcerczak, E. (2018). Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia. Oncology Letters, 15, 6733-6738. https://doi.org/10.3892/ol.2018.8143
MLA
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., Balcerczak, E."Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia". Oncology Letters 15.5 (2018): 6733-6738.
Chicago
Krygier, A., Szmajda, D., Żebrowska, M., Jeleń, A., Balcerczak, E."Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia". Oncology Letters 15, no. 5 (2018): 6733-6738. https://doi.org/10.3892/ol.2018.8143