Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer

  • Authors:
    • Daisuke Kitajima
    • Atsushi Kasamatsu
    • Dai Nakashima
    • Isao Miyamoto
    • Yasushi Kimura
    • Yosuke Endo‑Sakamoto
    • Masashi Shiiba
    • Hideki Tanzawa
    • Katsuhiro Uzawa
  • View Affiliations

  • Published online on: March 8, 2018     https://doi.org/10.3892/ol.2018.8212
  • Pages: 7237-7242
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Angiopoietin-1 (Ang1) is a binding partner of endothelial cell‑specific tyrosine‑protein kinase receptor (Tie2), which serves important roles in vascular development and angiogenesis. Tie2 is closely associated with the metastasis of oral squamous cell carcinomas (OSCCs) however, little is known about the correlation between Tie2 and Ang1. In the present study, the functional mechanisms of the Tie2/Ang1 interaction were investigated using Tie2 overexpressed (oeTie2) OSCC cells and recombinant Ang1 protein. oeTie2 cells had increased cell‑cell and cell‑extracellular matrix adhesions compared with the control cells. Additionally, the adhesive activities increased following treatment with exogenous Ang1, indicating that Ang1 directly enhances Tie2 functions. In the clinical OSCC data from 10 cases positive for regional lymph node metastasis, all cases were negative for Tie2 expression and eight cases (80%) were negative for Ang1 expression. These results suggest that Tie2 and Ang1 serve important roles in cancer metastasis and may be potential biomarkers and therapeutic targets for OSCC metastasis.
View Figures
View References

Related Articles

Journal Cover

May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Endo‑Sakamoto Y, Shiiba M, Tanzawa H and Uzawa K: Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer. Oncol Lett 15: 7237-7242, 2018
APA
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y. ... Uzawa, K. (2018). Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer. Oncology Letters, 15, 7237-7242. https://doi.org/10.3892/ol.2018.8212
MLA
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y., Shiiba, M., Tanzawa, H., Uzawa, K."Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer". Oncology Letters 15.5 (2018): 7237-7242.
Chicago
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y., Shiiba, M., Tanzawa, H., Uzawa, K."Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer". Oncology Letters 15, no. 5 (2018): 7237-7242. https://doi.org/10.3892/ol.2018.8212