Open Access

Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer

  • Authors:
    • Zelai Mo
    • Hailan Lu
    • Shaowei Mo
    • Xiangmin Fu
    • Shunwu Chang
    • Jie Yue
  • View Affiliations

  • Published online on: March 12, 2018     https://doi.org/10.3892/ol.2018.8231
  • Pages: 7014-7020
  • Copyright: © Mo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

For patients with liver cancer who are not sufficiently fit for surgical resection, radiofrequency ablation (RFA) is an effective and low risk treatment modality; however, the mechanism underlying this procedure is not fully understood. In the present study, a series of experiments were conducted, which demonstrated that RFA therapy stimulates innate antitumor immunity via directly enhancing natural killer (NK) cell cytotoxicity, thus achieving a favorable outcome for patients with liver tumors. It was determined that the percentage of NK cells within the peripheral blood of the rabbits in the RFA treatment groups were significantly higher, compared with the control groups. The levels of interferon‑γ and tumor necrosis factor‑α in NK cells were also significantly upregulated following thermal coagulation induced via RFA. In addition, RFA enhanced the NK cell receptor, NK group 2D (NKG2D), expression and NK cell antitumor cytotoxicity in hepatic cancer cells. The results indicated that the RFA treatment could effectively eliminate liver tumors via enhancing NK-mediated antitumor activity and NKG2D expression.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Mo Z, Lu H, Mo S, Fu X, Chang S and Yue J: Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer. Oncol Lett 15: 7014-7020, 2018
APA
Mo, Z., Lu, H., Mo, S., Fu, X., Chang, S., & Yue, J. (2018). Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer. Oncology Letters, 15, 7014-7020. https://doi.org/10.3892/ol.2018.8231
MLA
Mo, Z., Lu, H., Mo, S., Fu, X., Chang, S., Yue, J."Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer". Oncology Letters 15.5 (2018): 7014-7020.
Chicago
Mo, Z., Lu, H., Mo, S., Fu, X., Chang, S., Yue, J."Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer". Oncology Letters 15, no. 5 (2018): 7014-7020. https://doi.org/10.3892/ol.2018.8231