Open Access

Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report

  • Authors:
    • Tomofumi Naruse
    • Mitsuko Tokuhisa
    • Souichi Yanamoto
    • Yuki Sakamoto
    • Kohei Okuyama
    • Hiroki Tsuchihashi
    • Masahiro Umeda
  • View Affiliations

  • Published online on: March 14, 2018     https://doi.org/10.3892/ol.2018.8261
  • Pages: 7158-7162
  • Copyright: © Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Long-term cetuximab treatment can lead to acquired resistance, and tumor progression and/or new lesions often occur. The present report describes a case of lower gingival squamous cell carcinoma with brain metastasis during long‑term cetuximab treatment in a 60‑year‑old man, including findings of an immunohistochemical study. The resected primary tumors, biopsy of the lung metastasis before administration of cetuximab, and brain metastasis specimens mediated by cetuximab were immunohistochemically examined. Histologically, the metastatic brain lesion showed hyperkeratinizing tumor cells with deeply stained irregular nuclei with necrotizing tumor cells, and a decrease in cell density was exhibited in part of the tumor nest. Moreover, the brain lesion was less malignant compared with the primary tumor and metastatic lung lesions. Immunohistochemically, the metastatic brain lesions showed low expression of epidermal growth factor receptor (EGFR) and high expression of N‑cadherin compared with the primary tumor and metastatic lung lesions. These results suggest that acquired resistance to cetuximab may be associated with low EGFR expression and increased epithelial‑to‑mesenchymal transition potential.
View Figures
View References

Related Articles

Journal Cover

May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Naruse T, Tokuhisa M, Yanamoto S, Sakamoto Y, Okuyama K, Tsuchihashi H and Umeda M: Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report. Oncol Lett 15: 7158-7162, 2018
APA
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., & Umeda, M. (2018). Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report. Oncology Letters, 15, 7158-7162. https://doi.org/10.3892/ol.2018.8261
MLA
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., Umeda, M."Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report". Oncology Letters 15.5 (2018): 7158-7162.
Chicago
Naruse, T., Tokuhisa, M., Yanamoto, S., Sakamoto, Y., Okuyama, K., Tsuchihashi, H., Umeda, M."Lower gingival squamous cell carcinoma with brain metastasis during long-term cetuximab treatment: A case report". Oncology Letters 15, no. 5 (2018): 7158-7162. https://doi.org/10.3892/ol.2018.8261