Open Access

Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1

  • Authors:
    • Ying Guan
    • Jianqiang Chen
    • Yuefu Zhan
    • Hong Lu
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  • Published online on: March 15, 2018     https://doi.org/10.3892/ol.2018.8269
  • Pages: 7595-7602
  • Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dexamethasone (Dex) is commonly used to treat glioma; however, the mechanism underlying the action of Dex remains unclear. In the present study, the hypothesis that aquaporin‑1 (AQP1) may participate in tumor cell proliferation, apoptosis, migration and invasion was tested using small interfering RNA (siRNA). The results of the current study indicated that Dex could inhibit the proliferation, in addition to promoting the migration, of C6 cells. Dex was indicated to promote the expression of AQP1. Downregulation of AQP1, achieved using siRNAs, demonstrated the inhibition of cell proliferation, promotion of cell migration and suppression of invasion; therefore, Dex was indicated to serve a role in these effects in the C6 cells, via the upregulation of AQP1. This demonstrated that AQP1 could be utilized as a novel therapeutic target, with the aim of inhibiting the proliferation and metastasis of gliomas.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Guan Y, Chen J, Zhan Y and Lu H: Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1. Oncol Lett 15: 7595-7602, 2018.
APA
Guan, Y., Chen, J., Zhan, Y., & Lu, H. (2018). Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1. Oncology Letters, 15, 7595-7602. https://doi.org/10.3892/ol.2018.8269
MLA
Guan, Y., Chen, J., Zhan, Y., Lu, H."Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1". Oncology Letters 15.5 (2018): 7595-7602.
Chicago
Guan, Y., Chen, J., Zhan, Y., Lu, H."Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1". Oncology Letters 15, no. 5 (2018): 7595-7602. https://doi.org/10.3892/ol.2018.8269