Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma

  • Authors:
    • Dongyun Xu
    • Yuqing Miao
    • Xiaoqiang Gu
    • Jiejun Wang
    • Guanzhen Yu
  • View Affiliations

  • Published online on: March 15, 2018     https://doi.org/10.3892/ol.2018.8278
  • Pages: 8095-8101
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Abstract

The inorganic pyrophosphatase gene (PPA1) encodes inorganic pyrophosphatase, an enzyme that catalyzes the hydrolysis of inorganic pyrophosphate to orthophosphate, and has been revealed to be dysregulated in several types of human cancer. However, the role of PPA1 in intrahepatic cholangiocarcinoma (ICC) has not yet been determined. The present study detected PPA1 expression and investigated its clinical significance in ICC. Tissue microarray blocks containing 93 ICC specimens were constructed. The protein expression of PPA1 in these specimens was detected by immunohistochemistry. PPA1 was overexpressed in 49.5% of the ICC specimens and was significantly associated with large tumor size, positive margins, T stage, lymph nodal metastases, poorly differentiated tumors and advanced disease stage. Furthermore, PPA1 expression was an indicator of future recurrence and poor survival in patients with ICC. Increased expression of PPA1 is a common event in human ICC and is significantly associated with a poor outcome in patients with ICC, suggesting a potential role for PPA1 in the development and progression of ICC.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xu D, Miao Y, Gu X, Wang J and Yu G: Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma. Oncol Lett 15: 8095-8101, 2018
APA
Xu, D., Miao, Y., Gu, X., Wang, J., & Yu, G. (2018). Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma. Oncology Letters, 15, 8095-8101. https://doi.org/10.3892/ol.2018.8278
MLA
Xu, D., Miao, Y., Gu, X., Wang, J., Yu, G."Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma". Oncology Letters 15.5 (2018): 8095-8101.
Chicago
Xu, D., Miao, Y., Gu, X., Wang, J., Yu, G."Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma". Oncology Letters 15, no. 5 (2018): 8095-8101. https://doi.org/10.3892/ol.2018.8278