Association between ovarian cancer and advanced endometriosis

Matalliotakis,Michail; Matalliotaki,Charoula; Goulielmos,George N.; Patelarou,Evridiki; Tzardi,Maria; Spandidos,Demetrios A.; Arici,Aydin; Matalliotakis,Ioannis

doi:10.3892/ol.2018.8287

Association between ovarian cancer and advanced endometriosis

Authors:
- Michail Matalliotakis
- Charoula Matalliotaki
- George N. Goulielmos
- Evridiki Patelarou
- Maria Tzardi
- Demetrios A. Spandidos
- Aydin Arici
- Ioannis Matalliotakis
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Affiliations: Department of Obstetrics and Gynecology, Venizeleio General Hospital, 71409 Heraklion, Crete, Greece, Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Crete, Greece, School of Health Sciences and Welfare, Technological Educational Institute of Crete, 71004 Heraklion, Crete, Greece, Department of Histopathology, University Hospital of Heraklion, Faculty of Medicine, 71110 Heraklion, Crete, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Published online on: March 16, 2018 https://doi.org/10.3892/ol.2018.8287
Pages: 7689-7692
Copyright: © Matalliotakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We retrospectively analyzed clinicopathological data in two different countries over the past years on the association between ovarian endometriosis and ovarian carcinoma. Medical and pathological reports were evaluated from 1,000 patients with endometriosis from two different geographical areas. The prevalence and women characteristics of cases were analyzed. Endometriosis‑associated ovarian cancer was present in 20 (2%) cases, among the study subjects. The observed prevalence was 12 (60%) for endometrioid carcinoma, 4 (20%) for clear cell ovarian carcinoma, 2 (10%) for serous and 2 (10%) for mucinous adenocarcinoma. A higher proportion of endometrioid carcinoma cases were noted in comparison with other types (P<0.001). We found only 3/20 (15%) postmenopausal cases. In all cases, we reported advanced stage of endometriosis (stage III or IV). Left‑sided endometrioid carcinoma were notably more common than right‑sided ones (P<0.001). In the majority of cases, malignant transformation of endometriosis was observed in endometrioid carcinoma or clear cell carcinoma of the ovary. Further research is required to establish the relationship between endometriosis and ovarian cancer.

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