Open Access

Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer

  • Authors:
    • Ting Xiong
    • Xiao‑Wang Liu
    • Xue‑Long Huang
    • Xiong‑Feng Xu
    • Wei‑Quan Xie
    • Su‑Jun Zhang
    • Jian Tu
  • View Affiliations

  • Published online on: March 20, 2018     https://doi.org/10.3892/ol.2018.8299
  • Pages: 7817-7827
  • Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diallyl disulfide (DADS), a volatile component of garlic oil, has various biological properties, including antioxidant, antiangiogenic and anticancer effects. The present study aimed to explore novel targets of DADS that may slow or stop the progression of breast cancer. First, xenograft tumor models were created by subcutaneously injecting MCF‑7 and MDA‑MB‑231 breast cancer cells into nude mice. Subsequently, western blot analysis was performed to investigate the expression of tristetraprolin (TTP), urokinase‑type plasminogen activator (uPA) and matrix metalloproteinase‑9 (MMP‑9) in the xenograft tumors, and cell cultures. Tablet cloning, Transwell and wound healing assays revealed that DADS treatment significantly inhibited the proliferation, invasion and migration of breast cancer cells. In addition, DADS treatment led to significant downregulation of uPA and MMP‑9 protein expression, but significantly upregulated TTP expression in vivo and in vitro. Knocking down TTP expression using small interfering RNA reversed the aforementioned effects of DADS, which suggests TTP is a key target of DADS in inhibiting the progression of breast cancer.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xiong T, Liu XW, Huang XL, Xu XF, Xie WQ, Zhang SJ and Tu J: Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer. Oncol Lett 15: 7817-7827, 2018.
APA
Xiong, T., Liu, X., Huang, X., Xu, X., Xie, W., Zhang, S., & Tu, J. (2018). Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer. Oncology Letters, 15, 7817-7827. https://doi.org/10.3892/ol.2018.8299
MLA
Xiong, T., Liu, X., Huang, X., Xu, X., Xie, W., Zhang, S., Tu, J."Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer". Oncology Letters 15.5 (2018): 7817-7827.
Chicago
Xiong, T., Liu, X., Huang, X., Xu, X., Xie, W., Zhang, S., Tu, J."Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer". Oncology Letters 15, no. 5 (2018): 7817-7827. https://doi.org/10.3892/ol.2018.8299