Open Access

CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis

  • Authors:
    • Lu Yue
    • Zhen‑Ni Sun
    • Ya‑Sai Yao
    • Zan Shen
    • Hai‑Bo Wang
    • Xiang‑Ping Liu
    • Fang Zhou
    • Jin‑Yu Xiang
    • Ru‑Yong Yao
    • Hai‑Tao Niu
  • View Affiliations

  • Published online on: March 22, 2018     https://doi.org/10.3892/ol.2018.8316
  • Pages: 7515-7522
  • Copyright: © Yue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer (BC) is the most commonly diagnosed cancer in females globally and is more aggressive at later stages. Chromosome region maintenance 1 (CRM1) is involved in the nuclear export of proteins and RNAs and has been associated with a number of malignancies. However, the clinicopathological significance of its expression in BC remains to be elucidated therefore this was investigated in the present study. CRM1 expression in 280 breast cancer tissues and 60 normal tissues was retrospectively analyzed using immunohistochemistry (IHC) and western blotting. IHC investigation demonstrated that CRM1 expression was significantly increased in BC compared with the normal breast epithelium (P<0.0001). Overexpression of CRM1 was markedly associated with poor prognostic characteristics, including larger tumor size (P=0.024), positive lymph node metastasis (P=0.032), invasive histological type (P=0.004) and distant metastasis (P=0.026). Significant associations were also observed between increased CRM1 expression and the progesterone receptor (P=0.028) and Ki67 (P=0.019). Kaplan‑Meier survival analysis demonstrated that patients with high CRM1 expression exhibited a reduced disease‑free survival and overall survival compared with those with low CRM1 expression (P=0.013). In the multivariate analysis, CRM1 expression (P=0.011), tumor size (P=0.001) and lymph node metastasis (P<0.001) were independent prognostic markers of BC. In conclusion, CRM1 serves an important role in BC and may serve as a predictive and prognostic factor for a poor outcome in patients with BC.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yue L, Sun ZN, Yao YS, Shen Z, Wang HB, Liu XP, Zhou F, Xiang JY, Yao RY, Niu HT, Niu HT, et al: CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis. Oncol Lett 15: 7515-7522, 2018.
APA
Yue, L., Sun, Z., Yao, Y., Shen, Z., Wang, H., Liu, X. ... Niu, H. (2018). CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis. Oncology Letters, 15, 7515-7522. https://doi.org/10.3892/ol.2018.8316
MLA
Yue, L., Sun, Z., Yao, Y., Shen, Z., Wang, H., Liu, X., Zhou, F., Xiang, J., Yao, R., Niu, H."CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis". Oncology Letters 15.5 (2018): 7515-7522.
Chicago
Yue, L., Sun, Z., Yao, Y., Shen, Z., Wang, H., Liu, X., Zhou, F., Xiang, J., Yao, R., Niu, H."CRM1, a novel independent prognostic factor overexpressed in invasive breast carcinoma of poor prognosis". Oncology Letters 15, no. 5 (2018): 7515-7522. https://doi.org/10.3892/ol.2018.8316