Open Access

Increased KIF4A expression is a potential prognostic factor in prostate cancer

  • Authors:
    • Hongwei Gao
    • Xuanrong Chen
    • Qiliang Cai
    • Zhiqun Shang
    • Yuanjie Niu
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  • Published online on: March 22, 2018     https://doi.org/10.3892/ol.2018.8322
  • Pages: 7941-7947
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The kinesin super‑family protein (KIF) 4A gene is reported to be overexpressed and associated with poor clinical prognosis in human cancers; however, its clinical significance in prostate cancer (PCa) has not been well studied. The present study performed dataset analyses and revealed that KIF4A expression was significantly increased in castration‑resistant PCa patients. Additionally, KIF4A expression was significantly highly expressed in PCa tissues compared with non‑cancerous tissues, particularly in advanced PCa pathological stages. Upregulated KIF4A mRNA expression in PCa tissues was significantly correlated with shorter overall survival and prostate‑specific antigen failure. Furthermore, both univariate and multivariate analyses revealed that upregulated KIF4A may predict poor biochemical recurrence (BCR)‑free survival. The data suggested that KIF4A may play a key role in PCa progression. Notably, increased KIF4A expression may potentially predict poor BCR‑free survival in PCa patients.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gao H, Chen X, Cai Q, Shang Z and Niu Y: Increased KIF4A expression is a potential prognostic factor in prostate cancer. Oncol Lett 15: 7941-7947, 2018
APA
Gao, H., Chen, X., Cai, Q., Shang, Z., & Niu, Y. (2018). Increased KIF4A expression is a potential prognostic factor in prostate cancer. Oncology Letters, 15, 7941-7947. https://doi.org/10.3892/ol.2018.8322
MLA
Gao, H., Chen, X., Cai, Q., Shang, Z., Niu, Y."Increased KIF4A expression is a potential prognostic factor in prostate cancer". Oncology Letters 15.5 (2018): 7941-7947.
Chicago
Gao, H., Chen, X., Cai, Q., Shang, Z., Niu, Y."Increased KIF4A expression is a potential prognostic factor in prostate cancer". Oncology Letters 15, no. 5 (2018): 7941-7947. https://doi.org/10.3892/ol.2018.8322