Downregulation of BRAF‑activated non‑protein coding RNA in patients with hepatitis B virus‑associated hepatocellular carcinoma

Zhao,Na‑Na; Wang,Cheng; Lai,Cheng‑Cai; Cheng,Si‑Jie; Yan,Jin; Hong,Zhi‑Xian; Yu,Lin‑Xiang; Zhu,Zhen‑Yu; Zhang,Pei‑Rui; Wang,Zhao‑Hai; Wang,Xi‑Liang; Zhang,Shao‑Geng; Yang,Peng‑Hui

doi:10.3892/ol.2018.8327

Downregulation of BRAF‑activated non‑protein coding RNA in patients with hepatitis B virus‑associated hepatocellular carcinoma

Authors:
- Na‑Na Zhao
- Cheng Wang
- Cheng‑Cai Lai
- Si‑Jie Cheng
- Jin Yan
- Zhi‑Xian Hong
- Lin‑Xiang Yu
- Zhen‑Yu Zhu
- Pei‑Rui Zhang
- Zhao‑Hai Wang
- Xi‑Liang Wang
- Shao‑Geng Zhang
- Peng‑Hui Yang
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Affiliations: Department of Hepatobiliary Surgery, Beijing 302 Hospital, Beijing 100039, P.R. China, Department of Orthopedics, Beijing 307 Hospital Affiliated to Academy of Medical Sciences, Beijing 100071, P.R. China, Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, P.R. China
Published online on: March 22, 2018 https://doi.org/10.3892/ol.2018.8327
Pages: 7794-7798
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) have been investigated as a novel class of regulators of cellular processes, including cell growth, apoptosis and carcinogenesis. lncRNA BRAF‑activated non‑protein coding RNA (BANCR) has recently been revealed to be involved in tumorigenesis of numerous types of cancer, including papillary thyroid carcinoma, melanoma, non‑small cell lung cancer and colorectal cancer. However, the expression profiles and biological relevance of lncRNA BANCR in hepatocellular carcinoma (HCC) has not yet been reported. In the present study, the expression level of BANCR in tumor tissues and para‑cancerous tissues was determined by reverse transcription‑quantitative polymerase chain reaction in patients with hepatitis B virus (HBV)‑associated HCC, and its association with clinicopathological characteristics of patients was analyzed. The results demonstrated that the expression level of BANCR was significantly reduced in tumor tissues in comparison with in para‑cancerous tissues (P<0.001). Furthermore, the present study demonstrated that BANCR expression level was closely associated with serum α‑fetoprotein levels (P<0.01) and HCC tumor number (P<0.05). To the best of our knowledge, these results revealed for the first time that BANCR downregulated in patients with HBV‑associated HCC and BANCR expression level may be a potential valuable diagnosis and therapeutic biomarker in HCC.

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