High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer

  • Authors:
    • Yan Zhang
    • Jiaxuan Zhang
    • Qin Shen
    • Wei Yin
    • Hua Huang
    • Yifei Liu
    • Qingfeng Ni
  • View Affiliations

  • Published online on: March 28, 2018     https://doi.org/10.3892/ol.2018.8365
  • Pages: 8789-8795
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Abstract

Nectins are Ca2+‑independent immunoglobulin‑like cell adhesion molecules that belong to a family of four members that function in a number of biological cellular activities. Nectin‑4 is overexpressed in several types of human cancer; however, the functional and prognostic significance of Nectin‑4 in gastric cancer (GC) remains unclear. In the present study, the reverse transcription‑quantitative polymerase chain reaction and tissue microarray immunohistochemical analysis were used to investigate the expression of Nectin‑4 in GC as well as its function in the prognosis of patients with GC. The results indicated that mRNA and protein expression of Nectin‑4 were increased in tumor tissues compared with the matched non‑tumor tissues. Expression of Nectin‑4 was closely associated with differentiation (P=0.004), primary tumor (P=0.001), lymph node metastasis (P<0.001) and tumor‑node‑metastasis (TNM) stage (P<0.001). Positive Nectin‑4 expression (P=0.001) and advanced TNM stage (P<0.001) were demonstrated to be associated with overall survival time in multivariate analyses. These results suggest that Nectin‑4 may serve a significant function in GC and may serve as a novel clinic pathological biomarker and therapeutic target in GC.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Y, Zhang J, Shen Q, Yin W, Huang H, Liu Y and Ni Q: High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer. Oncol Lett 15: 8789-8795, 2018.
APA
Zhang, Y., Zhang, J., Shen, Q., Yin, W., Huang, H., Liu, Y., & Ni, Q. (2018). High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer. Oncology Letters, 15, 8789-8795. https://doi.org/10.3892/ol.2018.8365
MLA
Zhang, Y., Zhang, J., Shen, Q., Yin, W., Huang, H., Liu, Y., Ni, Q."High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer". Oncology Letters 15.6 (2018): 8789-8795.
Chicago
Zhang, Y., Zhang, J., Shen, Q., Yin, W., Huang, H., Liu, Y., Ni, Q."High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer". Oncology Letters 15, no. 6 (2018): 8789-8795. https://doi.org/10.3892/ol.2018.8365