Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway

Chen,Meng‑Ting; Sun,He‑Fen; Li,Liang‑Dong; Zhao,Yang; Yang,Li‑Peng; Gao,Shui‑Ping; Jin,Wei

doi:10.3892/ol.2018.8402

Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway

Authors:
- Meng‑Ting Chen
- He‑Fen Sun
- Liang‑Dong Li
- Yang Zhao
- Li‑Peng Yang
- Shui‑Ping Gao
- Wei Jin
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Affiliations: Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Collaborative Innovation Center of Cancer Medicine, Shanghai Cancer Center, Fudan University, Shanghai 200030, P.R. China, Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200030, P.R. China
Published online on: March 30, 2018 https://doi.org/10.3892/ol.2018.8402
Pages: 8582-8588
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer metastasis and relapse are the primary cause of mortality for patients with breast cancer. The present study performed quantitative proteomic analysis on the differentially expressed proteins between highly metastatic breast cancer cells and parental cells. It was revealed that forkhead box P2 (FOXP2), a transcription factor in neural development, may become a potential inhibitor of breast cancer metastasis. The results demonstrated that patients with a lower level of FOXP2 expression had significantly poorer relapse‑free survival (P=0.0047). The transcription of FOXP2 was also significantly downregulated in breast cancer tissue compared with normal breast tissue (P=0.0005). In addition, FOXP2 may inhibit breast cancer cell migration and invasion in vitro. It was also revealed that the underlying mechanism may include the epithelial‑mesenchymal transition process driven by the tumor growth factor β/SMAD signaling pathway. In conclusion, the present study identified FOXP2 as a novel suppressor and prognostic marker of breast cancer metastasis. These results may provide further insight into breast cancer prevention and the development of novel treatments.

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