Open Access

miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells

  • Authors:
    • Nadezhda Palkina
    • Anna Komina
    • Maria Aksenenko
    • Anton Moshev
    • Andrei Savchenko
    • Tatiana Ruksha
  • View Affiliations

  • Published online on: April 5, 2018     https://doi.org/10.3892/ol.2018.8443
  • Pages: 8269-8280
  • Copyright: © Palkina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA (miR)‑204‑5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR‑204‑5p and the newly‑identified miR‑3065‑5p, two miRNAs suggested to be tumor‑suppressive oncomiRs. Application of miR‑204‑5p mimics or inhibitors resulted in a decrease or increase, respectively, in melanoma cell proliferation and colony formation. miR‑204‑5p mimics hindered invasion, whereas miR‑204‑5p inhibitors stimulated cancer cell migration. Modulation of miR‑3065‑5p led to a decrease in melanoma cell proliferation, altered cell cycle distribution and increased expression levels of its target genes HIPK1 and ITGA1, possibly due to functional modifications identified in these cells. miR‑204‑5p and miR‑3065‑5p demonstrated antitumor capacities that may need to be taken into account in the development of melanoma treatment approaches.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Palkina N, Komina A, Aksenenko M, Moshev A, Savchenko A and Ruksha T: miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells. Oncol Lett 15: 8269-8280, 2018.
APA
Palkina, N., Komina, A., Aksenenko, M., Moshev, A., Savchenko, A., & Ruksha, T. (2018). miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells. Oncology Letters, 15, 8269-8280. https://doi.org/10.3892/ol.2018.8443
MLA
Palkina, N., Komina, A., Aksenenko, M., Moshev, A., Savchenko, A., Ruksha, T."miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells". Oncology Letters 15.6 (2018): 8269-8280.
Chicago
Palkina, N., Komina, A., Aksenenko, M., Moshev, A., Savchenko, A., Ruksha, T."miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells". Oncology Letters 15, no. 6 (2018): 8269-8280. https://doi.org/10.3892/ol.2018.8443