Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients

  • Authors:
    • Wei Liu
    • Yanmiao Huo
    • Jianyu Yang
    • Xueliang Fu
    • Minwei Yang
    • Lingye Tao
    • Dejun Liu
    • Junfeng Zhang
    • Rong Hua
    • Yongwei Sun
  • View Affiliations

  • Published online on: April 10, 2018     https://doi.org/10.3892/ol.2018.8452
  • Pages: 9287-9292
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Abstract

The present study aimed to investigate the expression level of ubiquitin specific peptidase 9X (USP9X) and its clinical significance in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). The mRNA expression levels of USP9X in 30 paired PDAC tissue samples were examined by reverse transcription‑quantitative polymerase chain reaction. The protein expression of USP9X was analyzed by immunohistochemistry (IHC) in a tissue microarray containing 205 PDAC specimens. All analyses were performed by SPSS 20.0 and GraphPad Prism 5.0 software. The USP9X mRNA level was significantly decreased in 18/30 (60.0%) PDAC tissue samples compared with matched surrounding non‑tumor tissue samples. The results of IHC revealed that decreased expression of USP9X was inversely associated with liver metastasis (P=0.032). Kaplan‑Meier survival curves indicated that patients with high expression of USP9X presented a longer clinical overall survival time (P<0.001). Univariate and multivariate COX regression analysis revealed that USP9X protein expression level was a significant, and independent prognostic factor for the overall survival rate of patients with PDAC. The results of the present study indicate that USP9X may serve as a candidate tumor suppressor and prognostic biomarker in PDAC.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu W, Huo Y, Yang J, Fu X, Yang M, Tao L, Liu D, Zhang J, Hua R, Sun Y, Sun Y, et al: Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients . Oncol Lett 15: 9287-9292, 2018.
APA
Liu, W., Huo, Y., Yang, J., Fu, X., Yang, M., Tao, L. ... Sun, Y. (2018). Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients . Oncology Letters, 15, 9287-9292. https://doi.org/10.3892/ol.2018.8452
MLA
Liu, W., Huo, Y., Yang, J., Fu, X., Yang, M., Tao, L., Liu, D., Zhang, J., Hua, R., Sun, Y."Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients ". Oncology Letters 15.6 (2018): 9287-9292.
Chicago
Liu, W., Huo, Y., Yang, J., Fu, X., Yang, M., Tao, L., Liu, D., Zhang, J., Hua, R., Sun, Y."Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients ". Oncology Letters 15, no. 6 (2018): 9287-9292. https://doi.org/10.3892/ol.2018.8452