Open Access

Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma

  • Authors:
    • Kui Zhao
    • Xiaoxu Li
    • Jiongke Wang
    • Jiajia Liu
    • Wang Gong
    • Hao Xu
    • Jiayi Wang
    • Lu Jiang
    • Hongxia Dan
    • Jing Li
    • Xin Zeng
    • Qianming Chen
  • View Affiliations

  • Published online on: April 11, 2018     https://doi.org/10.3892/ol.2018.8468
  • Pages: 9151-9161
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aetiology of oral squamous cell carcinoma (OSCC) remains unclear. Numerous single nucleotide polymorphisms (SNPs) associated with cancer have been identified using genome‑wide association studies (GWAS). The present study was designed to identify common SNPs associated with cancer susceptibility and to evaluate their involvement in OSCC. Susceptible loci were identified by analysing a cancer GWAS catalogue. A multicentre case‑control study using an OSCC and control population was performed for selected SNPs. The function of the selected locus and its associated gene was explored using a reverse transcription‑polymerase chain reaction, enzyme linked immunosorbent assay and immunohistochemistry. The association between genotypes and clinical parameters was assessed in 76 patients with OSCC. Rs2294008 located in the prostate stem cell antigen gene (PSCA) was selected. It was identified that the rs2294008 polymorphism was associated with OSCC susceptibility and PSCA may be involved in the development, progression and prognosis of OSCC.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao K, Li X, Wang J, Liu J, Gong W, Xu H, Wang J, Jiang L, Dan H, Li J, Li J, et al: Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma. Oncol Lett 15: 9151-9161, 2018.
APA
Zhao, K., Li, X., Wang, J., Liu, J., Gong, W., Xu, H. ... Chen, Q. (2018). Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma. Oncology Letters, 15, 9151-9161. https://doi.org/10.3892/ol.2018.8468
MLA
Zhao, K., Li, X., Wang, J., Liu, J., Gong, W., Xu, H., Wang, J., Jiang, L., Dan, H., Li, J., Zeng, X., Chen, Q."Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma". Oncology Letters 15.6 (2018): 9151-9161.
Chicago
Zhao, K., Li, X., Wang, J., Liu, J., Gong, W., Xu, H., Wang, J., Jiang, L., Dan, H., Li, J., Zeng, X., Chen, Q."Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma". Oncology Letters 15, no. 6 (2018): 9151-9161. https://doi.org/10.3892/ol.2018.8468