Tudor‑staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor‑κB and microRNA‑127 in human glioma U87MG cells

  • Authors:
    • Yongqiang Zhang
    • Jun Jia
    • Ying Li
    • Yan‑Ge Chen
    • Huan Huang
    • Yang Qiao
    • Yu Zhu
  • View Affiliations

  • Published online on: April 13, 2018     https://doi.org/10.3892/ol.2018.8484
  • Pages: 9553-9558
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glioma is one of the malignant tumor types detrimental to human health; therefore, it is important to find novel targets and therapeutics for this tumor. The downregulated expression of Tudor‑staphylococcal nuclease (SN) and alkylglycerone phosphate synthase (AGPS) can decrease cancer malignancy, and the overexpression of them can the increase viability and migration potential of various tumor cell types; however, the role of AGPS in the proliferation and migration of glioma, and the association of Tudor‑SN and AGPS in human glioma is not clear. In the present study, it was determined that AGPS silencing suppressed the proliferation and migration potential of glioma U87MG cells, and suppressed the expression of the circular RNAs circ‑ubiquitin‑associated protein 2, circ‑zinc finger protein 292 and circ‑homeodomain‑interacting protein kinase 3, and the long non‑coding RNAs H19 imprinted maternally expressed transcript (non‑protein coding), colon cancer‑associated transcript 1 (non‑protein coding) and hepatocellular carcinoma upregulated long non‑coding RNA. Furthermore, Tudor‑SN silencing suppressed the expression of AGPS; however, nuclear factor (NF)‑κB and microRNA (miR)‑127 retrieval experiments partially reduced the expression of AGPS. Additionally, it was determined that Tudor‑SN silencing suppressed the activity of the mechanistic target of rapamycin (mTOR) signaling pathway, and NF‑κB and miR‑127 retrieval experiments partially reduced the activity of mTOR. Therefore, it was considered that NF‑κB and miR‑127 may be the mediators of Tudor‑SN‑regulated AGPS via the mTOR signaling pathway. These results improve on our knowledge of the mechanisms underlying Tudor‑SN and AGPS in human glioma.
View Figures
View References

Related Articles

Journal Cover

June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Jia J, Li Y, Chen YG, Huang H, Qiao Y and Zhu Y: Tudor‑staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor‑κB and microRNA‑127 in human glioma U87MG cells. Oncol Lett 15: 9553-9558, 2018.
APA
Zhang, Y., Jia, J., Li, Y., Chen, Y., Huang, H., Qiao, Y., & Zhu, Y. (2018). Tudor‑staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor‑κB and microRNA‑127 in human glioma U87MG cells. Oncology Letters, 15, 9553-9558. https://doi.org/10.3892/ol.2018.8484
MLA
Zhang, Y., Jia, J., Li, Y., Chen, Y., Huang, H., Qiao, Y., Zhu, Y."Tudor‑staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor‑κB and microRNA‑127 in human glioma U87MG cells". Oncology Letters 15.6 (2018): 9553-9558.
Chicago
Zhang, Y., Jia, J., Li, Y., Chen, Y., Huang, H., Qiao, Y., Zhu, Y."Tudor‑staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor‑κB and microRNA‑127 in human glioma U87MG cells". Oncology Letters 15, no. 6 (2018): 9553-9558. https://doi.org/10.3892/ol.2018.8484