Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1

Xiao,Bing; Fan,Yanghua; Ye,Minhua; Lv,Shigang; Xu,Bin; Chai,Yi; Wu,Miaojin; Zhu,Xingen

doi:10.3892/ol.2018.8601

Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1

Authors:
- Bing Xiao
- Yanghua Fan
- Minhua Ye
- Shigang Lv
- Bin Xu
- Yi Chai
- Miaojin Wu
- Xingen Zhu
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Affiliations: Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
Published online on: April 27, 2018 https://doi.org/10.3892/ol.2018.8601
Pages: 9697-9702
Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chicken ovalbumin upstream promoter transcription factor II (COUP‑TFII) is a steroid receptor that is broadly expressed in many tissues throughout embryonic development. Previous studies indicated that COUP‑TFII is dysregulated in multiple types of cancer and serves crucial roles in cancer development. The mitochondrial pyruvate carrier 1 (MPC1) is involved in transporting pyruvate for entry into the citric acid cycle, an important event in cancer progression. However, the roles of COUP‑TFII and MPC1 in glioma remain unknown. In the present study, it was demonstrated that MPC1 is downregulated in glioblastoma. Furthermore, the inhibition of COUP‑TFII was able to increase MPC1 expression and inhibit the growth of glioblastoma cells in vitro and in vivo. The findings from the present study demonstrated that downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1. Therefore, COUP‑TFII is a potential therapeutic target for glioma.

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