Open Access

HPV16 E7 increases COX‑2 expression and promotes the proliferation of breast cancer

  • Authors:
    • Yong‑Xia Wang
    • Zhe‑Ying Zhang
    • Jian‑Qiang Wang
    • Xin‑Lai Qian
    • Jing Cui
  • View Affiliations

  • Published online on: May 3, 2018     https://doi.org/10.3892/ol.2018.8624
  • Pages: 317-325
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer remains the leading cause of mortality worldwide. Human papilloma virus 16 (HPV16) may serve a function in the pathogenesis and development of breast cancer. However, the detection rate of HPV16 in breast carcinoma may vary by region. In the present study, the expression of HPV16 E7 in paraffin‑embedded tissues from patients with breast cancer from North China was detected. Additionally, the molecular mechanisms underlying the function of HPV16 E7 in the proliferation of breast cancer cells were examined. The results demonstrated that the DNA of HPV16 E7 was detected in 30.5% of the samples, and that HPV16 E7 promoted the proliferation of breast cancer cells in vitro and in vivo. Additionally, HPV16 E7‑mediated proliferation of breast cancer cells was suppressed in response to treatment with cyclooxygenase‑2 (COX‑2)‑specific small interfering RNA and celecoxib. The results of the present study revealed that HPV16 E7 may promote the proliferation of breast cancer cells by upregulating COX‑2, suggesting that COX‑2 may be a potential therapeutic target for HPV16 E7‑mediated progression of breast cancer.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang YX, Zhang ZY, Wang JQ, Qian XL and Cui J: HPV16 E7 increases COX‑2 expression and promotes the proliferation of breast cancer. Oncol Lett 16: 317-325, 2018.
APA
Wang, Y., Zhang, Z., Wang, J., Qian, X., & Cui, J. (2018). HPV16 E7 increases COX‑2 expression and promotes the proliferation of breast cancer. Oncology Letters, 16, 317-325. https://doi.org/10.3892/ol.2018.8624
MLA
Wang, Y., Zhang, Z., Wang, J., Qian, X., Cui, J."HPV16 E7 increases COX‑2 expression and promotes the proliferation of breast cancer". Oncology Letters 16.1 (2018): 317-325.
Chicago
Wang, Y., Zhang, Z., Wang, J., Qian, X., Cui, J."HPV16 E7 increases COX‑2 expression and promotes the proliferation of breast cancer". Oncology Letters 16, no. 1 (2018): 317-325. https://doi.org/10.3892/ol.2018.8624