Undifferentiated sinonasal malignant melanoma: A case report

  • Authors:
    • Jun Du
    • Liang‑Liang Huang
    • Ao Xu
    • An‑Li Zhang
    • Xue Kong
    • Min Ding
    • Wen Hu
    • Zhen‑Li Guo
    • Wen Zhong
    • Si‑Bai Sun
    • Heng Li
    • Jie Chen
    • Qian Shen
    • Lu‑Lu Xu
    • Hai‑Bo Wu
  • View Affiliations

  • Published online on: May 8, 2018     https://doi.org/10.3892/ol.2018.8662
  • Pages: 580-584
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Abstract

Undifferentiated sinonasal malignant melanoma (MM) is a rare type of tumor, which can be easily misdiagnosed. The present study reports a 41‑year‑old male patient who presented with a 4‑day history of epistaxis. Clinical examination and radiological imaging lead to the detection of a mass in the right sinonasal region. Histopathological examination revealed that the mass was composed of malignant epithelioid cells arranged in nests and sheets. These cells displayed a hemangiopericytoma‑like pattern with antler‑like branching vessels. Immunohistochemical staining revealed that the tumor cells exhibited negative expression of melanocytic markers. This increased the difficulty of distinguishing undifferentiated MM from other malignant tumors located in the sinonasal area, particularly undifferentiated nasopharyngeal carcinoma. The diagnosis of undifferentiated MM was determined by ultrastructures, including the mature melanosomes and premelanosomes, in tumor cells by transmission electron microscopy. The present study suggests that the analysis of cancer stem cell marker and vasculogenic mimicry may be an important auxiliary tool for the diagnosis of MM.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Du J, Huang LL, Xu A, Zhang AL, Kong X, Ding M, Hu W, Guo ZL, Zhong W, Sun SB, Sun SB, et al: Undifferentiated sinonasal malignant melanoma: A case report. Oncol Lett 16: 580-584, 2018.
APA
Du, J., Huang, L., Xu, A., Zhang, A., Kong, X., Ding, M. ... Wu, H. (2018). Undifferentiated sinonasal malignant melanoma: A case report. Oncology Letters, 16, 580-584. https://doi.org/10.3892/ol.2018.8662
MLA
Du, J., Huang, L., Xu, A., Zhang, A., Kong, X., Ding, M., Hu, W., Guo, Z., Zhong, W., Sun, S., Li, H., Chen, J., Shen, Q., Xu, L., Wu, H."Undifferentiated sinonasal malignant melanoma: A case report". Oncology Letters 16.1 (2018): 580-584.
Chicago
Du, J., Huang, L., Xu, A., Zhang, A., Kong, X., Ding, M., Hu, W., Guo, Z., Zhong, W., Sun, S., Li, H., Chen, J., Shen, Q., Xu, L., Wu, H."Undifferentiated sinonasal malignant melanoma: A case report". Oncology Letters 16, no. 1 (2018): 580-584. https://doi.org/10.3892/ol.2018.8662