Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway

Ding,Lingchi; Yao,Weidong; Lu,Junguo; Gong,Jun; Zhang,Xiaodong

doi:10.3892/ol.2018.8673

Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non‑small cell lung cancer by regulating the Wnt/β‑catenin pathway

Authors:
- Lingchi Ding
- Weidong Yao
- Junguo Lu
- Jun Gong
- Xiaodong Zhang
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Affiliations: Department of Oncology, Nantong Tumor Hospital, Nantong, Jiangsu 226361, P.R. China
Published online on: May 8, 2018 https://doi.org/10.3892/ol.2018.8673
Pages: 453-458

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Abstract

Circular RNAs (circRNAs) are a large class of RNAs that have previously been identified to be involved in certain diseases, including the development of cancer. However, the role of circ_001569 in non‑small cell lung cancer (NSCLC) remains unknown. In the present study, it was demonstrated that expression levels of circ_001569 were significantly increased in NSCLC tissues compared with in adjacent normal tissues. Increased circ_001569 expression was closely associated with tumor differentiation, lymph node metastasis and Tumor‑Node‑Metastasis classification in NSCLC. Patients that exhibited higher circ_001569 expression demonstrated a poorer survival outcome compared with patients with lower circ_001569 expression. Functional assay results indicated that the knockdown of circ_001569 inhibited the cell proliferation ability of NSCLC in vitro. In addition, it was identified that circ_001569 knockdown reduced the mRNA and protein expression levels of Wnt/β‑catenin pathway‑associated genes proto‑oncogene protein Wnt1, transcription factor 4 and β‑catenin in NSCLC cells. Therefore, the results indicated that circ_001569 promoted cell proliferation by regulating the Wnt/β‑catenin pathway in NSCLC, and circ_001569 may be a potential target of NSCLC treatment.

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