Open Access

The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)

  • Authors:
    • Cong Wang
    • Zhenghuan Liu
    • Zhihui Xu
    • Xian Wu
    • Dongyang Zhang
    • Ziqi Zhang
    • Jianqin Wei
  • View Affiliations

  • Published online on: June 4, 2018     https://doi.org/10.3892/ol.2018.8896
  • Pages: 2071-2077
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chemokine ligand 25 (CCL25) and chemokine receptor 9 (CCR9) are important regulators of migration, proliferation and apoptosis in leukocytes and cancer cells. Blocking of the CCR9/CCL25 signal has been demonstrated to be a potential novel cancer therapy. Research into CCR9 and CCL25 has revealed their associated upstream and downstream signaling pathways; CCR9 is regulated by several immunological factors, including NOTCH, interleukin 2, interleukin 4 and retinoic acid. NOTCH in particular, has been revealed to be a crucial upstream regulator of CCR9. Furthermore, proteins including matrix metalloproteinases, P‑glycoprotein, Ezrin/Radixin/Moesin and Livin are regulated via phosphatidylinositol‑3 kinase/ protein kinase B, which are in turn stimulated by CCR9/CCL25. This is a review of the current literature on the functions and signaling pathways of CCR9/CCL25.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang C, Liu Z, Xu Z, Wu X, Zhang D, Zhang Z and Wei J: The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review). Oncol Lett 16: 2071-2077, 2018.
APA
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review). Oncology Letters, 16, 2071-2077. https://doi.org/10.3892/ol.2018.8896
MLA
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., Wei, J."The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)". Oncology Letters 16.2 (2018): 2071-2077.
Chicago
Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., Wei, J."The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)". Oncology Letters 16, no. 2 (2018): 2071-2077. https://doi.org/10.3892/ol.2018.8896