Open Access

miR‑184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7

  • Authors:
    • Daiyun Chen
    • Junfu Li
    • Shunrong Li
    • Ping Han
    • Ning Li
    • Yi Wang
    • Shouqin Du
  • View Affiliations

  • Published online on: June 5, 2018     https://doi.org/10.3892/ol.2018.8906
  • Pages: 2221-2228
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Abstract

The aim of this study was to investigate whether the miR‑184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex‑determining region Y‑box 7 (SOX7) gene. miR‑184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR‑184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR‑184 and luciferase reporter assay confirmed that miR‑184 downregulated the expression of SOX7. MTT assay verified that knockdown of SOX7 remarkably promoted the proliferation of TSCC cells in vitro. miR‑184 promoted the proliferation of TSCC by targeting SOX7. Taken together, our results provided a new potential therapeutic target for TSCC treatment.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen D, Li J, Li S, Han P, Li N, Wang Y and Du S: miR‑184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7. Oncol Lett 16: 2221-2228, 2018.
APA
Chen, D., Li, J., Li, S., Han, P., Li, N., Wang, Y., & Du, S. (2018). miR‑184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7. Oncology Letters, 16, 2221-2228. https://doi.org/10.3892/ol.2018.8906
MLA
Chen, D., Li, J., Li, S., Han, P., Li, N., Wang, Y., Du, S."miR‑184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7". Oncology Letters 16.2 (2018): 2221-2228.
Chicago
Chen, D., Li, J., Li, S., Han, P., Li, N., Wang, Y., Du, S."miR‑184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7". Oncology Letters 16, no. 2 (2018): 2221-2228. https://doi.org/10.3892/ol.2018.8906