Intracerebral schwannoma: A case report and literature review

Gao,Yufei; Qin,Zhigang; Li,Dongyuan; Yu,Weidong; Sun,Libo; Liu,Naijie; Zhao,Conghai; Zhang,Butian; Hu,Yu; Sun,Daju; Jin,Xingyi

doi:10.3892/ol.2018.8949

Intracerebral schwannoma: A case report and literature review

Authors:
- Yufei Gao
- Zhigang Qin
- Dongyuan Li
- Weidong Yu
- Libo Sun
- Naijie Liu
- Conghai Zhao
- Butian Zhang
- Yu Hu
- Daju Sun
- Xingyi Jin
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Affiliations: Department of Neurosurgery, The China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Radiology, The China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Pathology, The China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
Published online on: June 11, 2018 https://doi.org/10.3892/ol.2018.8949
Pages: 2501-2510

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Abstract

Intracranial schwannoma accounts for between 5 and 8% of intracranial tumors, whereas intracerebral schwannoma, a rare disease, accounts for <1% of intracranial schwannomas. In addition to the present case report, a total of 84 cases reported within China and elsewhere were reviewed and summarized, and the age of the tumor onset, the site of disease, imaging results, clinical presentation, pathological classification and prognosis were analyzed. The present case report described a 12‑year‑old female with an intracerebral schwannoma in the brainstem, who was followed‑up for 5 years using magnetic resonance imaging after a surgical resection without recurrence, and clinical symptoms were reported to have completely resolved. The incidence of intracerebral schwannoma was low among cases, and the correct diagnosis was not able to be made preoperatively, and the majority of cases were diagnosed on the basis of postoperative pathology. The majority of cases analyzed were supratentorial, occurring at an age ≤40 according to previous literature. In addition, 33% of patients presented with subtentorial schwannoma, occurring at an age >40. The prognosis was classified as good (patient can live independently) for the majority of patients if surgery was able to completely resect the lesion.

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1	Russel DS and Rubinstein LJ: Pathology of tumors of the nervous system. Edward Arnold; London: 1989, 1.
2	Casadei GP, Komori T, Scheithauer BW, Miller GM, Parisi JE and Kelly PJ: Intracranial parenchymal schwannoma. A clinicopathological and neuroimaging study of nine cases. J Neurosurg. 79:217–222. 1993. View Article : Google Scholar : PubMed/NCBI
3	Di Biasi C, Trasimeni G, Iannilli M, Polettini E and Gualdi GF: Intracerebral schwannoma: CT and MR findings. AJNR Am J Neuroradiol. 15:1956–1958. 1994.PubMed/NCBI
4	Paredes I, Jimenez Roldán L, Ramos A, Lobato RD and Ricoy JR: Intraparenchymal schwannomas: Report of two new cases studied with MRI and review of the literature. Clin Neurol Neurosurg. 114:42–46. 2012. View Article : Google Scholar : PubMed/NCBI
5	Gibson AA, Hendrick EB and Conen PE: Case reports. Intracerebral schwannoma. Report of a case. J Neurosurg. 24:552–557. 1966. View Article : Google Scholar : PubMed/NCBI
6	New PF: Intracerebral schwannoma. Case report. J Neurosurg. 36:795–797. 1972. View Article : Google Scholar : PubMed/NCBI
7	Ghatak NR, Norwood CW and Davis CH: Intracerebral schwannoma. Surg Neurol. 3:45–47. 1975.PubMed/NCBI
8	Pialat J, Sindou M, Courjon J, Tommasi M and Mansuy L: Un cas de neurinome intracerebral frontal. Lyon Med. 234:129–134. 1975.(In French).
9	Van Rensburg MJ, Proctor NS, Danziger J and Orelowitz MS: Temporal lobe epilepsy due to an intracerebral Schwannoma: Case report. J Neurol Neurosurg Psychiatry. 38:703–709. 1975. View Article : Google Scholar : PubMed/NCBI
10	Hockley AD and Hendrick EB: Unilateral proptosis and intracranial schwannoma. Surg Neurol. 4:509–512. 1975.PubMed/NCBI
11	Hahn J and Netsky M: Brain tumors of mixed tissue origin: Staining procedures to distinguish glial from connective tissue. South Med J. 70:539–542. 1977. View Article : Google Scholar : PubMed/NCBI
12	Kasantikul V, Brown WJ and Cahan LD: Intracerebral neurilemmoma. J Neurol Neurosurg Psychiatry. 44:1110–1115. 1981. View Article : Google Scholar : PubMed/NCBI
13	Auer RN, Budny J, Drake CG and Ball MJ: Frontal lobe perivascular schwannoma. Case report. J Neurosurg. 56:154–157. 1982. View Article : Google Scholar : PubMed/NCBI
14	Shalit MN, Toledo E and Sandbank U: Intracerebral schwannoma. Acta Neurochir (Wein). 64:253–258. 1982. View Article : Google Scholar
15	Gokay H, Izgi N, Barlas O and Erseven G: Supratentorial intracerebral schwannomas. Surg Neurol. 22:69–72. 1984. View Article : Google Scholar : PubMed/NCBI
16	Bruni P, Esposito S, Greco R and Oddi G: Solitary intracerebral schwannoma in von Recklinghausen's disease. Surg Neurol. 22:360–364. 1984. View Article : Google Scholar : PubMed/NCBI
17	Stefanko SZ, Vuzevski VD, Maas AI and van Vroonhoven CC: Intracerebral malignant schwannoma. Acta Neuropathol. 71:321–325. 1986. View Article : Google Scholar : PubMed/NCBI
18	Schwartz AM and Sotrel A: Intracerebral and intracerebellar neurilemoma. South Med J. 81:385–388. 1988. View Article : Google Scholar : PubMed/NCBI
19	Ezura M, Ikeda H, Ogawa A and Yoshimoto T: Intracerebral schwannoma: Case report. Neurosurgery. 30:97–100. 1992. View Article : Google Scholar : PubMed/NCBI
20	Ghosh S and Chandy MJ: Solitary ectopic intracerebral schwannoma. Br J Neurosurg. 6:163–166. 1992. View Article : Google Scholar : PubMed/NCBI
21	Frim DM, Ogilvy CS, Vonsattal JP and Chapman PH: Is intracerebral schwannoma a developmental tumor of children and young adults? Case report and review. Pediatr Neurosurg. 18:190–194. 1992. View Article : Google Scholar : PubMed/NCBI
22	Sarkar C, Mehta VS and Roy S: Intracerebellar schwannoma. Case report. J Neurosurg. 67:120–123. 1987. View Article : Google Scholar : PubMed/NCBI
23	Rodriguez-Salazar A, Carrillo R and de Miguel J: Intracerebral schwannoma in a child: Report of a case. Childs Brain. 11:69–72. 1984.PubMed/NCBI
24	Bruner JM, Hunphreys JH and Armstrong OL: Intracerebral nerve sheath tumor. J Neuropathol Exp Neurol. 43:2961984. View Article : Google Scholar
25	Deng C and Wu P: Intracranial ectopic neurilemoma: Report of two cases. J Nantong University. 1:46–47. 1985.
26	Aryanpur J and Long DM: Schwannoma of the medulla oblongata. Case report. J Neurosurg. 69:446–449. 1988. View Article : Google Scholar : PubMed/NCBI
27	Ladouceur D, Bergeron D, Lamarche JB and Lamontagne L: Cystic schwannoma of the brainstem. Can J Neurol Sci. 16:357–360. 1989. View Article : Google Scholar : PubMed/NCBI
28	Redekop G, Elisevich K and Gilbert J: Fourth ventricular schwannoma. Case report. J Neurosurg. 73:777–781. 1990. View Article : Google Scholar : PubMed/NCBI
29	Tran-Dinh HD, Soo YS, O'Neil P and Chaseling R: Cystic cerebellar schwannoma: Case report. Neurosurgery. 29:296–299; discussion 299–300. 1991. View Article : Google Scholar : PubMed/NCBI
30	Sharma RR, Gurusinghe NT, Lynch PG, Parekh HC and Bertolis G: Intraparenchymatous schwannoma of the cerebellum. Br J Neurosurg. 7:83–89. 1993. View Article : Google Scholar : PubMed/NCBI
31	Sharma V and Newton G: Schwannoma of the medulla oblongata. Br J Neurosurg. 7:427–429. 1993. View Article : Google Scholar : PubMed/NCBI
32	Zhao X, Wang Y and Duan M: Mixed brain cysticercosis with intracerebral schwannoma: A case study. Chin J Neurosurg. 10:2801994.(In Chinese).
33	Erongun U, Ozkal E, Acar O, Uygun A, Kocaoğullar Y and Gungor S: Intracerebral schwannoma: Case report and review. Neurosurg Rev. 19:269–274. 1996. View Article : Google Scholar : PubMed/NCBI
34	Sharma MC, Karak AK, Gaikwad SB, Mahapatra AK, Mehta VS and Sudha K: Intracranial intraparenchymal schwannomas: A series of eight cases. J Neurol Neurosurg Psychiatry. 60:200–203. 1996. View Article : Google Scholar : PubMed/NCBI
35	Tsuiki H, Kuratsu J, Ishimaru Y, Nakahara T, Kishida K, Takamura M, Marubayashi T and Ushio Y: Intracranial intraparenchymal schwannoma: Report of three cases. Acta Neurochir (Wein). 139:756–760. 1997. View Article : Google Scholar
36	Wang H, Shi J, Tan Q and Sun K: Case report: Intracerebral schwannoma without the relationship of the brain nerve trunk. JiangSu Med J. 26:869–870. 2000.(In Chinese).
37	Andrade GC, Neto Paiva MA and Braga FM: Thalamic intracerebral schwannoma: Case report. Arq Neuropsiquiatr. 60:308–313. 2002.(In Portuguese). View Article : Google Scholar : PubMed/NCBI
38	Xu J and Wang Y: One case of intracerebral schwannoma. Chin J Neurosurg. 18:862002.(In Chinese).
39	Lin J, Feng H, Li F, Zhao B and Guo Q: Intraparenchymal schwannoma of the medulla oblongata. Case report. J Neurosurg. 98:621–624. 2003. View Article : Google Scholar : PubMed/NCBI
40	Zhong Q, Zhang X and Zhang Y: A case of schwannoma in brain parenchyma. Chin J Radiol. 38:1119–1120. 2004.(In Chinese).
41	Zeng E, Yuan X, Jiang W and Chen F: Brainstem schwannoma: One case report. Chin J Minima Invas Neurosur. 10:4732005.
42	Maiuri F, Colella G, D'Acunzi G and De Caro Mdel B: Malignant intracerebellar schwannoma. J Neurooncol. 66:191–195. 2004. View Article : Google Scholar : PubMed/NCBI
43	Anton T, Guttierez J and Rock J: Tentorial schwannoma: A case report and review of the literature. J Neurooncol. 76:307–311. 2006. View Article : Google Scholar : PubMed/NCBI
44	Celikoğlu E, Hakan T and Bozbuğa M: Cystic schwannoma of the falx cerebri. J Clin Neurosci. 14:589–592. 2007. View Article : Google Scholar : PubMed/NCBI
45	Xu D, Chen D and Zhang Y: Magnetic resonance imaging of schwannoma in brain parenchyma (report of 3 cases). J Rare Uncom Dis. 14:7–10. 2007.
46	Yi Y, Zhou J and Lv S: A case of schwannoma in brain parenchyma. 19:300–301. 2008.
47	Ishihara M, Miyagawa-Hayashino A, Nakashima Y, Haga H, Takahashi JA and Manabe T: Intracerebral schwannoma in a child with infiltration along perivascular spaces resembling meningioangiomatosis. Pathol Int. 59:583–587. 2009. View Article : Google Scholar : PubMed/NCBI
48	Muzzafar S, Ketonen L, Weinberg JS and Schellingerhout D: Imaging and clinical features of an intra-axial brain stem schwannoma. AJNR Am J Neuroradiol. 31:567–569. 2010. View Article : Google Scholar : PubMed/NCBI
49	Zhu Q, Jiang X and Ren Z: Schwannoma in brain parenchyma and literature review. Anhui Med J. 31:156–158. 2010.(In Chinese).
50	Consales A, Rossi A, Nozza P, Ravegnani M, Garrè ML and Cama A: Intracerebral schwannoma in a child. Br J Neurosurg. 24:306–308. 2010. View Article : Google Scholar : PubMed/NCBI
51	Guha D, Kiehl TR, Krings T and Valiante TA: Intracerebral schwannoma presenting as classic temporal lobe epilepsy. J Neurosurg. 117:136–140. 2012. View Article : Google Scholar : PubMed/NCBI
52	Srinivas R, Krupashankar D and Shasi V: Intracerebral schwannoma in a 16-year-old girl: A case report and review of the literature. Case Rep Neurol Med. 2013:1714942013.PubMed/NCBI
53	Lee S, Park SH and Chung CK: Supratentorial intracerebral schwannoma: Its fate and proper management. J Korean Neurosurg Soc. 54:340–343. 2013. View Article : Google Scholar : PubMed/NCBI
54	Ma L, Yang SX and Wang YR: Intracerebral schwannoma mimicking parasagittal meningioma. J Craniofac Surg. 24:e541–e543. 2013. View Article : Google Scholar : PubMed/NCBI
55	AlBatly AA, Zakzouk RS and Alhaidey AK: An atypical case of intracerebral schwannoma. Pan Afr Med J. 18:3422014. View Article : Google Scholar : PubMed/NCBI
56	Wilson BR, Steinberg JA, Snyder V, Jiang MN and Carter BS: Histologic evidence for arteriovenous malformation-like vasculature occurring within an intracerebral Schwannoma: A case report and review of the literature. World Neurosurg. 92:582 e589–582, e513. 2016. View Article : Google Scholar
57	Osborn AB and Salzman K: Diagnostic imaging: Brain Amirsys. Salt Lake City: 2007
58	Feigin I and Ogata J: Schwann cells and peripheral myelin within human central nervous tissues: The mesenchymal character of Schwann cells. J Neuropathol Exp Neurol. 30:603–612. 1971. View Article : Google Scholar : PubMed/NCBI
59	Nelson E and Rennels M: Innervation of intracranial arteries. Brain. 93:475–490. 1970. View Article : Google Scholar : PubMed/NCBI
60	Scherer SS: The biology and pathobiology of Schwann cells. Curr Opin Neurol. 10:386–397. 1997. View Article : Google Scholar : PubMed/NCBI
61	Woodhoo A and Sommer L: Development of the Schwann cell lineage: From the neural crest to the myelinated nerve. Glia. 56:1481–1490. 2008. View Article : Google Scholar : PubMed/NCBI
62	Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A and Jessen KR: Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation. J Peripher Nerv Syst. 13:122–135. 2008. View Article : Google Scholar : PubMed/NCBI
63	Trotter J: The development of myelin-forming glia: Studies with primary cell cultures and immortalized cell lines. Perspect Dev Neurobiol. 1:149–154. 1993.PubMed/NCBI
64	Iu Chelyshev A and Saitkulov KI: The development, phenotypic characteristics and communications of Schwann cells. Usp Fiziol Nauk. 31:54–69. 2000.(In Russian).
65	Li Q and Xu Z: Nervous system tumor pathology and genetics. People's Medical Publishing House Co., LTD.;