Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway

Wu,Shuying; Chen,Hong

doi:10.3892/ol.2018.8983

Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway

Authors:
- Shuying Wu
- Hong Chen
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Affiliations: Department of Dermatology, Tianjin Union Medical Center, Tianjin 300121, P.R. China
Published online on: June 18, 2018 https://doi.org/10.3892/ol.2018.8983
Pages: 3241-3247

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Abstract

The present study aimed to identify the probable anti‑Condyloma acuminata (CA) mechanism of microRNA‑375 (miRNA‑375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells.

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