Role of gastroscopic biopsy of gastric ulcer margins and healed sites in the diagnosis of early gastric cancer: A clinical controlled study of 513 cases

Wan,Jing‑Jing; Fei,Su‑Juan; Lv,Sheng‑Xiang; Han,Shu‑Tang; Ma,Xing‑Gang; Xu,Dong‑Sheng; Chen,Hong‑Mei; Zhang,Ju

doi:10.3892/ol.2018.9156

Role of gastroscopic biopsy of gastric ulcer margins and healed sites in the diagnosis of early gastric cancer: A clinical controlled study of 513 cases

Authors:
- Jing‑Jing Wan
- Su‑Juan Fei
- Sheng‑Xiang Lv
- Shu‑Tang Han
- Xing‑Gang Ma
- Dong‑Sheng Xu
- Hong‑Mei Chen
- Ju Zhang
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Affiliations: Digestive Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of Gastroenterology, Xuzhou Medical University Affiliated Hospital, Xuzhou, Jiangsu 221004, P.R. China, Department of Gastroenterology, Huaian Hospital Affiliated to Xuzhou Medical University, Huai'an, Jiangsu 223002, P.R. China
Published online on: July 17, 2018 https://doi.org/10.3892/ol.2018.9156
Pages: 4211-4218
Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present case study aimed to evaluate the effect of gastroscopic biopsy of gastric ulcer margins and healed sites in the diagnosis of early gastric cancer. A total of 513 patients who were diagnosed with gastric ulcers using gastroscopy between January 1999 and December 2013 were included in the present study and were divided into either the experimental or the control group. In the control group, samples were only taken from the ulcer margin, whereas in the experimental group samples were taken from the ulcer margin and from the ulcer base. In the experimental group, a routine biopsy of the ulcer margin was performed on first examination, and recheck by gastroscopy was performed from the second week. For ulcers that remained unhealed, a biopsy of the ulcer margin was subsequently conducted; however, for healed or almost healed ulcers, a biopsy of the ulcer base was conducted. The duration of follow‑up by gastroscopy ranged between 1 week and 24 months. For the control group, a biopsy of the ulcer margin was conducted using the conventional method. The detection rate of the experimental group was 3.88% (9/232), with 4 cases of gastric cancer confirmed from examinations of the ulcer base. The detection rate of the control group was 1.07% (3/281), which was significantly decreased compared with that of the experimental group (P=0.0345). Overall, patients who underwent regular follow‑up gastroscopy following treatment exhibited a markedly increased detection rate of early gastric cancer, suggesting that early cancer may occur in healed gastric ulcer sites.

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