AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma

Wang,Fen; Tong,Anli; Li,Chunyan; Cui,Yunying; Sun,Jian; Song,Ailing; Li,Yuxiu

doi:10.3892/ol.2018.9210

AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma

Authors:
- Fen Wang
- Anli Tong
- Chunyan Li
- Yunying Cui
- Jian Sun
- Ailing Song
- Yuxiu Li
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Affiliations: Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China
Published online on: July 25, 2018 https://doi.org/10.3892/ol.2018.9210
Pages: 4561-4566

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Abstract

Ectopic adrenocorticotropic hormone (ACTH) syndrome is usually caused by pulmonary and bronchial tumors and rarely by pheochromocytoma. To date, the majority of ACTH‑secreting pheochromocytomas have been unilateral, with the exception of two cases. A 54‑year‑old male presented with hypertension and bilateral adrenal tumors. The patient did not report having classic cushingoid features or experience of paroxysmal headaches or sweating, but presented with a slight abdominal obesity. The patient was clinically and pathologically diagnosed with bilateral ectopic ACTH‑secreting pheochromocytomas. Whole‑exome sequencing demonstrated that the 19 pheochromocytoma‑related genes were unmutated. The pheochromocytomas on the two sides exhibited negative ACTH staining, but the ACTH concentration was markedly higher in the tumor tissue homogenates than in those tumors of another 3 patients with non‑ACTH secretion pheochromocytoma. Electron microscopy identified two types of neuroendocrine cells in the tumor tissues. Primary culture of the pheochromocytoma cells revealed that ACTH secretion was inhibited by a mechanistic target of rapamycin inhibitor, AZD8055.

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