search button
Open Access

miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1

  • Authors:
    • Anhao Wu
    • Yan Chen
    • Yang Liu
    • Yafang Lai
    • Dequan Liu

  • View Affiliations

  • Published online on: August 2, 2018     https://doi.org/10.3892/ol.2018.9255
  • Pages: 4889-4896

  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Triple negative breast cancer (TNBC) has received increasing attention from oncologists worldwide due to its poor prognosis and paucity of targeted therapies. MicroRNAs (miRs) are a group of small non‑coding RNAs that are responsible for the post‑transcriptional regulation of various target genes. The present study demonstrated that the expression of miR‑199b‑5p in breast cancer tissue was significantly reduced compared with that in normal breast tissues by reverse transcription‑quantitative polymerase chain reaction. In addition, western blot analysis and luciferase reporter assays revealed that miR‑199b‑5p in TNBC cells inhibited discoidin domain receptor tyrosine kinase 1 expression by directly targeting its 3'‑untranslated region. Furthermore, miR‑199b‑5p markedly suppressed the proliferation and invasion of TNBC cells, as demonstrated by using wound‑healing, migration, invasion and proliferation assays. Collectively, these results indicate that miR‑199b‑5p may be a novel alternative therapeutic target for TNBC.
View Figures
View References

Related Articles

Journal Cover

October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Wu A, Chen Y, Liu Y, Lai Y and Liu D: miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1. Oncol Lett 16: 4889-4896, 2018.
APA
Wu, A., Chen, Y., Liu, Y., Lai, Y., & Liu, D. (2018). miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1. Oncology Letters, 16, 4889-4896. https://doi.org/10.3892/ol.2018.9255
MLA
Wu, A., Chen, Y., Liu, Y., Lai, Y., Liu, D."miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1". Oncology Letters 16.4 (2018): 4889-4896.
Chicago
Wu, A., Chen, Y., Liu, Y., Lai, Y., Liu, D."miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1". Oncology Letters 16, no. 4 (2018): 4889-4896. https://doi.org/10.3892/ol.2018.9255